LSD1: biologic roles and therapeutic targeting

por Maiques-Diaz, Alba, Somervaille, Tim CP
Publicado 2016

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

por Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Publicado 2018

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

por Williams, Mark S., Amaral, Fabio M.R., Simeoni, Fabrizio, Somervaille, Tim C.P.
Publicado 2020

AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells

por Pearson, Stella, Blance, Rognvald, Somervaille, Tim C.P., Whetton, Anthony D., Pierce, Andrew
Publicado 2019

Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

por Wiseman, Daniel H, Baker, Syed M, Dongre, Arundhati V, Gurashi, Kristian, Storer, Joanna A, Somervaille, Tim CP, Batta, Kiran
Publicado 2020

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

por Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.
Publicado 2023

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

por Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Publicado 2018

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

por Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.
Publicado 2021

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

por Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Publicado 2018

Addition of Navitoclax to Ongoing Ruxolitinib Therapy for Patients With Myelofibrosis With Progression or Suboptimal Response: Phase II Safety and Efficacy

por Harrison, Claire N., Garcia, Jacqueline S., Somervaille, Tim C.P., Foran, James M., Verstovsek, Srdan, Jamieson, Catriona, Mesa, Ruben, Ritchie, Ellen K., Tantravahi, Srinivas K., Vachhani, Pankit, O'Connell, Casey L., Komrokji, Rami S., Harb, Jason, Hutti, Jessica E., Holes, Leanne, Masud, Abdullah A., Nuthalapati, Silpa, Potluri, Jalaja, Pemmaraju, Naveen
Publicado 2022

Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

por Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.
Publicado 2019

Coordinated Alterations in RNA Splicing and Epigenetic Regulation Drive Leukemogenesis

por Yoshimi, Akihide, Lin, Kuan-Ting, Wiseman, Daniel H., Rahman, Mohammad Alinoor, Pastore, Alessandro, Wang, Bo, Lee, Stanley Chun-Wei, Micol, Jean-Baptiste, Zhang, Xiao Jing, de Botton, Stephane, Penard-Lacronique, Virginie, Stein, Eytan M., Cho, Hana, Miles, Rachel E., Inoue, Daichi, Albrecht, Todd R., Somervaille, Tim C.P., Batta, Kiran, Amaral, Fabio, Simeoni, Fabrizio, Wilks, Deepti P., Cargo, Catherine, Intlekofer, Andrew M., Levine, Ross L., Dvinge, Heidi, Bradley, Robert K., Wagner, Eric J., Krainer, Adrian R., Abdel-Wahab, Omar
Publicado 2019