Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

por Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Publicado 2013

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

por Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Publicado 2014

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

por Hur, Stella K., Somerville, Tim D.D., Wu, Xiaoli S., Maia-Silva, Diogo, Demerdash, Osama E., Tuveson, David A., Notta, Faiyaz, Vakoc, Christopher R.
Publicado 2023

TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma

por Somerville, Tim D.D., Xu, Yali, Miyabayashi, Koji, Tiriac, Hervé, Cleary, Cristian R., Maia-Silva, Diogo, Milazzo, Joseph P., Tuveson, David A., Vakoc, Christopher R.
Publicado 2018

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

por Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Publicado 2018

Frequent reconstitution of IDH2(R140Q) mutant clonal multilineage hematopoiesis following chemotherapy for acute myeloid leukemia

por Wiseman, Daniel H., Williams, Emma L., Wilks, Deepti P., Sun Leong, Hui, Somerville, Tim D. D., Dennis, Michael W., Struys, Eduard A., Bakkali, Abdellatif, Salomons, Gajja S., Somervaille, Tim C. P.
Publicado 2016

POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer

por Huang, Yu-Han, Klingbeil, Olaf, He, Xue-Yan, Wu, Xiaoli S., Arun, Gayatri, Lu, Bin, Somerville, Tim D.D., Milazzo, Joseph P., Wilkinson, John E., Demerdash, Osama E., Spector, David L., Egeblad, Mikala, Shi, Junwei, Vakoc, Christopher R.
Publicado 2018

SOAT1 promotes mevalonate pathway dependency in pancreatic cancer

por Oni, Tobiloba E., Biffi, Giulia, Baker, Lindsey A., Hao, Yuan, Tonelli, Claudia, Somerville, Tim D.D., Deschênes, Astrid, Belleau, Pascal, Hwang, Chang-il, Sánchez-Rivera, Francisco J., Cox, Hilary, Brosnan, Erin, Doshi, Abhishek, Lumia, Rebecca P., Khaledi, Kimia, Park, Youngkyu, Trotman, Lloyd C., Lowe, Scott W., Krasnitz, Alexander, Vakoc, Christopher R., Tuveson, David A.
Publicado 2020