Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

por Sommers, Joshua A., Suhasini, Avvaru N., Brosh, Robert M.
Publicado 2015

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks

por Parvathaneni, Swetha, Stortchevoi, Alexei, Sommers, Joshua A., Brosh, Robert M., Sharma, Sudha
Publicado 2013

Abstract 2676: SARS-CoV-2 Nsp13 Catalytic Efficiency is Regulated by ATP: Mg2+ Stoichiometry and Functional Cooperativity Among Nsp13 Molecules

por Haren, Caitlin, Sommers, Joshua, Loftus, Lorin, Jones, Martin, Lee, Rebecca, Dumm, Adaira, Brosh, Robert
Publicado 2023

Abstract 2677: The SARS-CoV-2 Nsp13 Helicase Required for Coronavirus Replication Interacts with Structured Nucleic Acids in a Strand-Specific Manner and Catalyzes a Novel Protein-...

por Dumm, Adaira, Sommers, Joshua, Loftus, Lorin, Jones, Martin, Lee, Rebecca, Haren, Caitlin, Brosh, Robert
Publicado 2023

The interaction site of Flap Endonuclease-1 with WRN helicase suggests a coordination of WRN and PCNA

por Sharma, Sudha, Sommers, Joshua A., Gary, Ronald K., Friedrich-Heineken, Erica, Hübscher, Ulrich, Brosh, Robert M.
Publicado 2005

Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand

por Gupta, Rigu, Sharma, Sudha, Doherty, Kevin M., Sommers, Joshua A., Cantor, Sharon B., Brosh, Robert M.
Publicado 2006

Impact of Age-Associated Cyclopurine Lesions on DNA Repair Helicases

por Khan, Irfan, Suhasini, Avvaru N., Banerjee, Taraswi, Sommers, Joshua A., Kaplan, Daniel L., Kuper, Jochen, Kisker, Caroline, Brosh, Robert M.
Publicado 2014

CDK1 phosphorylates WRN at collapsed replication forks

por Palermo, Valentina, Rinalducci, Sara, Sanchez, Massimo, Grillini, Francesca, Sommers, Joshua A., Brosh, Robert M., Zolla, Lello, Franchitto, Annapaola, Pichierri, Pietro
Publicado 2016

Biochemical analysis of SARS-CoV-2 Nsp13 helicase implicated in COVID-19 and factors that regulate its catalytic functions

por Sommers, Joshua A., Loftus, Lorin N., Jones, Martin P., Lee, Rebecca A., Haren, Caitlin E., Dumm, Adaira J., Brosh, Robert M.
Publicado 2023

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

por Sommers, Joshua A., Kulikowicz, Tomasz, Croteau, Deborah L., Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Bohr, Vilhelm A., Brosh, Robert M.
Publicado 2019

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

por Noto, Alessandro, Valenzisi, Pasquale, Fratini, Federica, Kulikowicz, Tomasz, Sommers, Joshua A., Di Feo, Flavia, Palermo, Valentina, Semproni, Maurizio, Crescenzi, Marco, Brosh, Robert M., Franchitto, Annapaola, Pichierri, Pietro
Publicado 2023

WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells

por Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Publicado 2021

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

por Bharti, Sanjay Kumar, Sommers, Joshua A, Awate, Sanket, Bellani, Marina A, Khan, Irfan, Bradley, Lynda, King, Graeme A, Seol, Yeonee, Vidhyasagar, Venkatasubramanian, Wu, Yuliang, Abe, Takuye, Kobayashi, Koji, Shin-ya, Kazuo, Kitao, Hiroyuki, Wold, Marc S, Branzei, Dana, Neuman, Keir C, Brosh, Robert M
Publicado 2018

RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1

por Abu-Libdeh, Bassam, Jhujh, Satpal S., Dhar, Srijita, Sommers, Joshua A., Datta, Arindam, Longo, Gabriel M.C., Grange, Laura J., Reynolds, John J., Cooke, Sophie L., McNee, Gavin S., Hollingworth, Robert, Woodward, Beth L., Ganesh, Anil N., Smerdon, Stephen J., Nicolae, Claudia M., Durlacher-Betzer, Karina, Molho-Pessach, Vered, Abu-Libdeh, Abdulsalam, Meiner, Vardiella, Moldovan, George-Lucian, Roukos, Vassilis, Harel, Tamar, Brosh, Robert M., Stewart, Grant S.
Publicado 2022