Covalent flexible peptide docking in Rosetta

por Tivon, Barr, Gabizon, Ronen, Somsen, Bente A., Cossar, Peter J., Ottmann, Christian, London, Nir
Publicado 2021

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach

por Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2023

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

por Somsen, Bente A., Sijbesma, Eline, Leysen, Seppe, Honzejkova, Karolina, Visser, Emira J., Cossar, Peter J., Obšil, Tomáš, Brunsveld, Luc, Ottmann, Christian
Publicado 2023

Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers

por Sijbesma, Eline, Somsen, Bente A., Miley, Galen P., Leijten-van de Gevel, Iris A., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Publicado 2020

Ultra-large chemical libraries for the discovery of high-affinity peptide binders

por Quartararo, Anthony J., Gates, Zachary P., Somsen, Bente A., Hartrampf, Nina, Ye, Xiyun, Shimada, Arisa, Kajihara, Yasuhiro, Ottmann, Christian, Pentelute, Bradley L.
Publicado 2020

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

por Somsen, Bente A., Craenmehr, Fenna W. B., Liu, Wei-Hong W., Koops, Auke A., Pennings, Marloes A. M., Visser, Emira J., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2022

Structure–Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

por Meijer, Femke A., Saris, Annet O.W.M., Doveston, Richard G., Oerlemans, Guido J.M., de Vries, Rens M.J.M., Somsen, Bente A., Unger, Anke, Klebl, Bert, Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc
Publicado 2021