Asymmetric anti-CLL-1×CD3 bispecific antibody, ABL602 2+1, with attenuated CD3 affinity endows potent antitumor activity but limited cytokine release

por Lee, Eunhee, Lee, Shinai, Park, Sumyeong, Son, Yong-Gyu, Yoo, Jiseon, Koh, Youngil, Shin, Dong-Yeop, Lim, Yangmi, Won, Jonghwa
Publicado 2023

N-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stability

por Ko, Min Ji, Song, Daehae, Kim, Juhee, Kim, Jae Yong, Eom, Jaehyun, Sung, Byungje, Son, Yong-Gyu, Kim, Young Min, Lee, Sang Hoon, You, Weon-Kyoo, Jung, Jinwon
Publicado 2021

B7-H3×4-1BB bispecific antibody augments antitumor immunity by enhancing terminally differentiated CD8(+) tumor-infiltrating lymphocytes

por You, Gihoon, Lee, Yangsoon, Kang, Yeon-Woo, Park, Han Wook, Park, Kyeongsu, Kim, Hyekang, Kim, Young-Min, Kim, Sora, Kim, Ji-Hae, Moon, Dain, Chung, Hyejin, Son, Wonjun, Jung, Ui-jung, Park, Eunyoung, Lee, Shinai, Son, Yong-Gyu, Eom, Jaehyun, Won, Jonghwa, Park, Yunji, Jung, Jaeho, Lee, Seung-Woo
Publicado 2021

Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade

por Jeong, Seongju, Park, Eunyoung, Kim, Hyung-Don, Sung, Eunsil, Kim, Hyunjoo, Jeon, Jaehyoung, Kim, Youngkwang, Jung, Ui-jung, Son, Yong-Gyu, Hong, Youngeun, Lee, Hanbyul, Lee, Shinai, Lim, Yangmi, Won, Jonghwa, Jeon, Minwoo, Hwang, Shin, Fang, Lei, Jiang, Wenqing, Wang, Zhengyi, Shin, Eui-Cheol, Park, Su-Hyung, Jung, Jaeho
Publicado 2021

LAG-3xPD-L1 bispecific antibody potentiates antitumor responses of T cells through dendritic cell activation

por Sung, Eunsil, Ko, Minkyung, Won, Ju-young, Jo, Yunju, Park, Eunyoung, Kim, Hyunjoo, Choi, Eunji, Jung, Ui-jung, Jeon, Jaehyoung, Kim, Youngkwang, Ahn, Hyejin, Choi, Da-som, Choi, Seunghyun, Hong, Youngeun, Park, Hyeyoung, Lee, Hanbyul, Son, Yong-Gyu, Park, Kyeongsu, Won, Jonghwa, Oh, Soo Jin, Lee, Seonmin, Kim, Kyu-pyo, Yoo, Changhoon, Song, Hyun Kyu, Jin, Hyung-seung, Jung, Jaeho, Park, Yoon
Publicado 2022