DNA Double-Strand Break Repair as Determinant of Cellular Radiosensitivity to Killing and Target in Radiation Therapy

por Mladenov, Emil, Magin, Simon, Soni, Aashish, Iliakis, George
Publicado 2013

ATR Contributes More Than ATM in Intra-S-Phase Checkpoint Activation after IR, and DNA-PKcs Facilitates Recovery: Evidence for Modular Integration of ATM/ATR/DNA-PKcs Functions

por Soni, Aashish, Duan, Xiaolu, Stuschke, Martin, Iliakis, George
Publicado 2022

The p38/MK2 Pathway Functions as Chk1-Backup Downstream of ATM/ATR in G(2)-Checkpoint Activation in Cells Exposed to Ionizing Radiation

por Luo, Daxian, Mladenov, Emil, Soni, Aashish, Stuschke, Martin, Iliakis, George
Publicado 2023

Radiation-dose-dependent functional synergisms between ATM, ATR and DNA-PKcs in checkpoint control and resection in G(2)-phase

por Mladenov, Emil, Fan, Xiaoxiang, Dueva, Rositsa, Soni, Aashish, Iliakis, George
Publicado 2019

DNA-PKcs and ATM epistatically suppress DNA end resection and hyperactivation of ATR-dependent G(2)-checkpoint in S-phase irradiated cells

por Mladenov, Emil, Fan, Xiaoxiang, Paul-Konietzko, Katja, Soni, Aashish, Iliakis, George
Publicado 2019

PTEN Loss Enhances Error-Prone DSB Processing and Tumor Cell Radiosensitivity by Suppressing RAD51 Expression and Homologous Recombination

por Pei, Xile, Mladenov, Emil, Soni, Aashish, Li, Fanghua, Stuschke, Martin, Iliakis, George
Publicado 2022

BMN673 Is a PARP Inhibitor with Unique Radiosensitizing Properties: Mechanisms and Potential in Radiation Therapy

por Soni, Aashish, Lin, Xixi, Mladenov, Emil, Mladenova, Veronika, Stuschke, Martin, Iliakis, George
Publicado 2022

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

por Soni, Aashish, Siemann, Maria, Grabos, Martha, Murmann, Tamara, Pantelias, Gabriel E., Iliakis, George
Publicado 2014

Disruption of Chromatin Dynamics by Hypotonic Stress Suppresses HR and Shifts DSB Processing to Error-Prone SSA

por Krieger, Lisa Marie, Mladenov, Emil, Soni, Aashish, Demond, Marilen, Stuschke, Martin, Iliakis, George
Publicado 2021

Low CDK Activity and Enhanced Degradation by APC/C(CDH1) Abolishes CtIP Activity and Alt-EJ in Quiescent Cells

por Li, Fanghua, Mladenov, Emil, Sun, Yanjie, Soni, Aashish, Stuschke, Martin, Timmermann, Beate, Iliakis, George
Publicado 2023

Chromosome thripsis by DNA double strand break clusters causes enhanced cell lethality, chromosomal translocations and 53BP1-recruitment

por Schipler, Agnes, Mladenova, Veronika, Soni, Aashish, Nikolov, Vladimir, Saha, Janapriya, Mladenov, Emil, Iliakis, George
Publicado 2016

Strong suppression of gene conversion with increasing DNA double-strand break load delimited by 53BP1 and RAD52

por Mladenov, Emil, Staudt, Christian, Soni, Aashish, Murmann-Konda, Tamara, Siemann-Loekes, Maria, Iliakis, George
Publicado 2020

NTRK1/TrkA Activation Overrides the G(2)/M-Checkpoint upon Irradiation

por Hassiepen, Christina, Soni, Aashish, Rudolf, Ines, Boron, Vivian, Oeck, Sebastian, Iliakis, George, Schramm, Alexander
Publicado 2021

G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells

por Nikolakopoulou, Aggeliki, Soni, Aashish, Habibi, Martha, Karaiskos, Pantelis, Pantelias, Gabriel, Terzoudi, Georgia I., Iliakis, George
Publicado 2021

Increased Resection at DSBs in G(2)-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ

por Xiao, Huaping, Li, Fanghua, Mladenov, Emil, Soni, Aashish, Mladenova, Veronika, Pan, Bing, Dueva, Rositsa, Stuschke, Martin, Timmermann, Beate, Iliakis, George
Publicado 2022