Synthesis of sp(3)-rich heterocyclic frameworks by a divergent synthesis strategy

por Mortensen, Kim T., Wong, Denedy S. Y., King, Thomas A., Sore, Hannah F., Spring, David R.
Publicado 2023

Recent Applications of Diversity-Oriented Synthesis Toward Novel, 3-Dimensional Fragment Collections

por Kidd, Sarah L., Osberger, Thomas J., Mateu, Natalia, Sore, Hannah F., Spring, David R.
Publicado 2018

Stereocontrolled semi-syntheses of deguelin and tephrosin

por Russell, David A., Freudenreich, Julien J., Ciardiello, Joe J., Sore, Hannah F., Spring, David R.
Publicado 2017

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

por Mateu, Natalia, Kidd, Sarah L., Kalash, Leen, Sore, Hannah F., Madin, Andrew, Bender, Andreas, Spring, David R.
Publicado 2018

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

por De Fusco, Claudia, Brear, Paul, Iegre, Jessica, Georgiou, Kathy Hadje, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2017

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery

por King, Thomas A., Stewart, Hannah L., Mortensen, Kim T., North, Andrew J. P., Sore, Hannah F., Spring, David R.
Publicado 2019

(Z)-Selective Takai olefination of salicylaldehydes

por Geddis, Stephen M, Hagerman, Caroline E, Galloway, Warren R J D, Sore, Hannah F, Goodman, Jonathan M, Spring, David R
Publicado 2017

Partially Saturated Bicyclic Heteroaromatics as an sp(3)‐Enriched Fragment Collection

por Twigg, David G., Kondo, Noriyasu, Mitchell, Sophie L., Galloway, Warren R. J. D., Sore, Hannah F., Madin, Andrew, Spring, David R.
Publicado 2016

A Multidimensional Diversity‐Oriented Synthesis Strategy for Structurally Diverse and Complex Macrocycles

por Nie, Feilin, Kunciw, Dominique L., Wilcke, David, Stokes, Jamie E., Galloway, Warren R. J. D., Bartlett, Sean, Sore, Hannah F., Spring, David R.
Publicado 2016

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

por Brear, Paul, North, Andrew, Iegre, Jessica, Hadje Georgiou, Kathy, Lubin, Alexandra, Carro, Laura, Green, William, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2018

Development of a Multifunctional Benzophenone Linker for Peptide Stapling and Photoaffinity Labelling

por Wu, Yuteng, Olsen, Lasse B., Lau, Yu Heng, Jensen, Claus Hatt, Rossmann, Maxim, Baker, Ysobel R., Sore, Hannah F., Collins, Súil, Spring, David R.
Publicado 2016

Second-generation CK2α inhibitors targeting the αD pocket

por Iegre, Jessica, Brear, Paul, De Fusco, Claudia, Yoshida, Masao, Mitchell, Sophie L., Rossmann, Maxim, Carro, Laura, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2018

Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

por Walsh, Stephen J., Omarjee, Soleilmane, Galloway, Warren R. J. D., Kwan, Terence T.-L., Sore, Hannah F., Parker, Jeremy S., Hyvönen, Marko, Carroll, Jason S., Spring, David R.
Publicado 2018

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates

por Walsh, Stephen J., Omarjee, Soleilmane, Galloway, Warren R. J. D., Kwan, Terence T.-L., Sore, Hannah F., Parker, Jeremy S., Hyvönen, Marko, Carroll, Jason S., Spring, David R.
Publicado 2018

Divergent Synthesis of Novel Cylindrocyclophanes that Inhibit Methicillin‐Resistant Staphylococcus aureus (MRSA)

por Freudenreich, Julien J., Bartlett, Sean, Robertson, Naomi S., Kidd, Sarah L., Forrest, Suzie, Sore, Hannah F., Galloway, Warren R. J. D., Welch, Martin, Spring, David R.
Publicado 2020

Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

por Wiedmann, Mareike M., Tan, Yaw Sing, Wu, Yuteng, Aibara, Shintaro, Xu, Wenshu, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura, Stewart, Murray, Brenton, James D., Spring, David R.
Publicado 2016

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

por Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Verma, Chandra S., Hyvönen, Marko, Spring, David R.
Publicado 2019

Specific inhibition of CK2α from an anchor outside the active site

por Brear, Paul, De Fusco, Claudia, Hadje Georgiou, Kathy, Francis-Newton, Nicola J., Stubbs, Christopher J., Sore, Hannah F., Venkitaraman, Ashok R., Abell, Chris, Spring, David R., Hyvönen, Marko
Publicado 2016

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

por Isidro-Llobet, Albert, Hadje Georgiou, Kathy, Galloway, Warren R. J. D., Giacomini, Elisa, Hansen, Mette R., Méndez-Abt, Gabriela, Tan, Yaw Sing, Carro, Laura, Sore, Hannah F., Spring, David R.
Publicado 2015

Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

por Sharma, Krishna, Strizhak, Alexander V., Fowler, Elaine, Xu, Wenshu, Chappell, Ben, Sore, Hannah F., Galloway, Warren R. J. D., Grayson, Matthew N., Lau, Yu Heng, Itzhaki, Laura S., Spring, David R.
Publicado 2020