Structural basis of Keap1 interactions with Nrf2

por Canning, Peter, Sorrell, Fiona J., Bullock, Alex N.
Publicado 2015

Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis

por Sorrell, Fiona J., Kilian, Lena Marie, Elkins, Jonathan M.
Publicado 2019

Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1

por Wilbek, Theis S, Skovgaard, Tine, Sorrell, Fiona J, Knapp, Stefan, Berthelsen, Jens, Strømgaard, Kristian
Publicado 2015

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

por Schumacher, Frances-Rose, Sorrell, Fiona J., Alessi, Dario R., Bullock, Alex N., Kurz, Thimo
Publicado 2014

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases

por Sorrell, Fiona J., Szklarz, Marta, Abdul Azeez, Kamal R., Elkins, Jon M., Knapp, Stefan
Publicado 2016

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

por Pinkas, Daniel M., Sanvitale, Caroline E., Bufton, Joshua C., Sorrell, Fiona J., Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N.
Publicado 2017

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors

por Henderson, Scott H., Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Ashall-Kelly, Alexander, Hopkins Navratilova, Iva, Walter, Daryl S., Elkins, Jonathan M., Ward, Simon E.
Publicado 2021

Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase

por Chen, Zhuoyao, Zhang, Jinwei, Murillo-de-Ozores, Adrián R., Castañeda-Bueno, María, D'Amico, Francesca, Heilig, Raphael, Manning, Charlotte E., Sorrell, Fiona J., D'Angiolella, Vincenzo, Fischer, Roman, Mulder, Monique P. C., Gamba, Gerardo, Alessi, Dario R., Bullock, Alex N.
Publicado 2022

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop

por Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.
Publicado 2019

Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model

por Fromont, Christophe, Atzori, Alessio, Kaur, Divneet, Hashmi, Lubna, Greco, Graziella, Cabanillas, Alejandro, Nguyen, Huy Van, Jones, D. Heulyn, Garzón, Miguel, Varela, Ana, Stevenson, Brett, Iacobini, Greg P., Lenoir, Marc, Rajesh, Sundaresan, Box, Clare, Kumar, Jitendra, Grant, Paige, Novitskaya, Vera, Morgan, Juliet, Sorrell, Fiona J., Redondo, Clara, Kramer, Andreas, Harris, C. John, Leighton, Brendan, Vickers, Steven P., Cheetham, Sharon C., Kenyon, Colin, Grabowska, Anna M., Overduin, Michael, Berditchevski, Fedor, Weston, Chris J., Knapp, Stefan, Fischer, Peter M., Butterworth, Sam
Publicado 2020