Analysis of Compound Synergy in High-Throughput Cellular Screens by Population-Based Lifetime Modeling

por Peifer, Martin, Weiss, Jonathan, Sos, Martin L., Koker, Mirjam, Heynck, Stefanie, Netzer, Christian, Fischer, Stefanie, Rode, Haridas, Rauh, Daniel, Rahnenführer, Jörg, Thomas, Roman K.
Publicado 2010

L1CAM protein expression is associated with poor prognosis in non-small cell lung cancer

por Tischler, Verena, Pfeifer, Marco, Hausladen, Silke, Schirmer, Uwe, Bonde, Anne-Katrine, Kristiansen, Glen, Sos, Martin L, Weder, Walter, Moch, Holger, Altevogt, Peter, Soltermann, Alex
Publicado 2011

Early Detection of Erlotinib Treatment Response in NSCLC by 3′-Deoxy-3′-[(18)F]-Fluoro-L-Thymidine ([(18)F]FLT) Positron Emission Tomography (PET)

por Ullrich, Roland T., Zander, Thomas, Neumaier, Bernd, Koker, Mirjam, Shimamura, Takeshi, Waerzeggers, Yannic, Borgman, Christa L., Tawadros, Samir, Li, Hongfeng, Sos, Martin L., Backes, Heiko, Shapiro, Geoffrey I., Wolf, Jürgen, Jacobs, Andreas H., Thomas, Roman K., Winkeler, Alexandra
Publicado 2008

CD74-NRG1 Fusions Are Oncogenic In Vivo and Induce Therapeutically Tractable ERBB2:ERBB3 Heterodimerization

por Werr, Lisa, Plenker, Dennis, Dammert, Marcel A., Lorenz, Carina, Brägelmann, Johannes, Tumbrink, Hannah L., Klein, Sebastian, Schmitt, Anna, Büttner, Reinhard, Persigehl, Thorsten, Shokat, Kevan M., Wunderlich, F. Thomas, Schram, Alison M., Peifer, Martin, Sos, Martin L., Reinhardt, H. Christian, Thomas, Roman K.
Publicado 2022

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes

por Bebber, Christina M., Thomas, Emily S., Stroh, Jenny, Chen, Zhiyi, Androulidaki, Ariadne, Schmitt, Anna, Höhne, Michaela N., Stüker, Lukas, de Pádua Alves, Cleidson, Khonsari, Armin, Dammert, Marcel A., Parmaksiz, Fatma, Tumbrink, Hannah L., Beleggia, Filippo, Sos, Martin L., Riemer, Jan, George, Julie, Brodesser, Susanne, Thomas, Roman K., Christian Reinhardt, H., von Karstedt, Silvia
Publicado 2021

Definition of a fluorescence in-situ hybridization score identifies high- and low-level FGFR1 amplification types in squamous cell lung cancer

por Schildhaus, Hans-Ulrich, Heukamp, Lukas C, Merkelbach-Bruse, Sabine, Riesner, Katharina, Schmitz, Katja, Binot, Elke, Paggen, Ellen, Albus, Kerstin, Schulte, Wolfgang, Ko, Yon-Dschun, Schlesinger, Andreas, Ansén, Sascha, Engel-Riedel, Walburga, Brockmann, Michael, Serke, Monika, Gerigk, Ulrich, Huss, Sebastian, Göke, Friederike, Perner, Sven, Hekmat, Khosro, Frank, Konrad F, Reiser, Marcel, Schnell, Roland, Bos, Marc, Mattonet, Christian, Sos, Martin, Stoelben, Erich, Wolf, Jürgen, Zander, Thomas, Buettner, Reinhard
Publicado 2012

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

por Dammert, Marcel A., Brägelmann, Johannes, Olsen, Rachelle R., Böhm, Stefanie, Monhasery, Niloufar, Whitney, Christopher P., Chalishazar, Milind D., Tumbrink, Hannah L., Guthrie, Matthew R., Klein, Sebastian, Ireland, Abbie S., Ryan, Jeremy, Schmitt, Anna, Marx, Annika, Ozretić, Luka, Castiglione, Roberta, Lorenz, Carina, Jachimowicz, Ron D., Wolf, Elmar, Thomas, Roman K., Poirier, John T., Büttner, Reinhard, Sen, Triparna, Byers, Lauren A., Reinhardt, H. Christian, Letai, Anthony, Oliver, Trudy G., Sos, Martin L.
Publicado 2019

Sorafenib and everolimus in patients with advanced solid tumors and KRAS‐mutated NSCLC: A phase I trial with early pharmacodynamic FDG‐PET assessment

por Nogova, Lucia, Mattonet, Christian, Scheffler, Matthias, Taubert, Max, Gardizi, Masyar, Sos, Martin L., Michels, Sebastian, Fischer, Rieke N., Limburg, Meike, Abdulla, Diana S.Y., Persigehl, Thorsten, Kobe, Carsten, Merkelbach‐Bruse, Sabine, Franklin, Jeremy, Backes, Heiko, Schnell, Roland, Behringer, Dirk, Kaminsky, Britta, Eichstaedt, Martina, Stelzer, Christoph, Kinzig, Martina, Sörgel, Fritz, Tian, Yingying, Junge, Lisa, Suleiman, Ahmed A., Frechen, Sebastian, Rokitta, Dennis, Ouyang, Dongsheng, Fuhr, Uwe, Buettner, Reinhard, Wolf, Jürgen
Publicado 2020

Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer

por Schaufler, Diana, Ast, David F., Tumbrink, Hannah L., Abedpour, Nima, Maas, Lukas, Schwäbe, Ayla E., Spille, Inga, Lennartz, Stefanie, Fassunke, Jana, Aldea, Mihaela, Besse, Benjamin, Planchard, David, Nogova, Lucia, Michels, Sebastian, Kobe, Carsten, Persigehl, Thorsten, Westphal, Theresa, Koleczko, Sophia, Fischer, Rieke, Weber, Jan-Phillip, Altmüller, Janine, Thomas, Roman K., Merkelbach-Bruse, Sabine, Gautschi, Oliver, Mezquita, Laura, Büttner, Reinhard, Wolf, Jürgen, Peifer, Martin, Brägelmann, Johannes, Scheffler, Matthias, Sos, Martin L.
Publicado 2021

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma

por Brägelmann, Johannes, Dammert, Marcel A., Dietlein, Felix, Heuckmann, Johannes M., Choidas, Axel, Böhm, Stefanie, Richters, André, Basu, Debjit, Tischler, Verena, Lorenz, Carina, Habenberger, Peter, Fang, Zhizhou, Ortiz-Cuaran, Sandra, Leenders, Frauke, Eickhoff, Jan, Koch, Uwe, Getlik, Matthäus, Termathe, Martin, Sallouh, Muhammad, Greff, Zoltán, Varga, Zoltán, Balke-Want, Hyatt, French, Christopher A., Peifer, Martin, Reinhardt, H. Christian, Örfi, László, Kéri, György, Ansén, Sascha, Heukamp, Lukas C., Büttner, Reinhard, Rauh, Daniel, Klebl, Bert M., Thomas, Roman K., Sos, Martin L.
Publicado 2017

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I

por Brägelmann, Johannes, Lorenz, Carina, Borchmann, Sven, Nishii, Kazuya, Wegner, Julia, Meder, Lydia, Ostendorp, Jenny, Ast, David F., Heimsoeth, Alena, Nakasuka, Takamasa, Hirabae, Atsuko, Okawa, Sachi, Dammert, Marcel A., Plenker, Dennis, Klein, Sebastian, Lohneis, Philipp, Gu, Jianing, Godfrey, Laura K., Forster, Jan, Trajkovic-Arsic, Marija, Zillinger, Thomas, Haarmann, Mareike, Quaas, Alexander, Lennartz, Stefanie, Schmiel, Marcel, D’Rozario, Joshua, Thomas, Emily S., Li, Henry, Schmitt, Clemens A., George, Julie, Thomas, Roman K., von Karstedt, Silvia, Hartmann, Gunther, Büttner, Reinhard, Ullrich, Roland T., Siveke, Jens T., Ohashi, Kadoaki, Schlee, Martin, Sos, Martin L.
Publicado 2021

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

por Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., Schinzel, Anna C., Sandy, Peter, Meylan, Etienne, Scholl, Claudia, Fröhling, Stefan, Chan, Edmond M., Sos, Martin L., Michel, Kathrin, Mermel, Craig, Silver, Serena J., Weir, Barbara A., Reiling, Jan H., Sheng, Qing, Gupta, Piyush B., Wadlow, Raymond C., Le, Hanh, Hoersch, Sebastian, Wittner, Ben S., Ramaswamy, Sridhar, Livingston, David M., Sabatini, David M., Meyerson, Matthew, Thomas, Roman K., Lander, Eric S., Mesirov, Jill P., Root, David E., Gilliland, D. Gary, Jacks, Tyler, Hahn, William C.
Publicado 2009

Overcoming EGFR(G724S)-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors

por Fassunke, Jana, Müller, Fabienne, Keul, Marina, Michels, Sebastian, Dammert, Marcel A., Schmitt, Anna, Plenker, Dennis, Lategahn, Jonas, Heydt, Carina, Brägelmann, Johannes, Tumbrink, Hannah L., Alber, Yannic, Klein, Sebastian, Heimsoeth, Alena, Dahmen, Ilona, Fischer, Rieke N., Scheffler, Matthias, Ihle, Michaela A., Priesner, Vanessa, Scheel, Andreas H., Wagener, Svenja, Kron, Anna, Frank, Konrad, Garbert, Katia, Persigehl, Thorsten, Püsken, Michael, Haneder, Stefan, Schaaf, Bernhard, Rodermann, Ernst, Engel-Riedel, Walburga, Felip, Enriqueta, Smit, Egbert F., Merkelbach-Bruse, Sabine, Reinhardt, H. Christian, Kast, Stefan M., Wolf, Jürgen, Rauh, Daniel, Büttner, Reinhard, Sos, Martin L.
Publicado 2018

Genomic Profiling Identifies Outcome-Relevant Mechanisms of Innate and Acquired Resistance to Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy in...

por Michels, Sebastian, Heydt, Carina, van Veggel, Bianca, Deschler-Baier, Barbara, Pardo, Nuria, Monkhorst, Kim, Rüsseler, Vanessa, Stratmann, Jan, Griesinger, Frank, Steinhauser, Susanne, Kostenko, Anna, Diebold, Joachim, Fassunke, Jana, Fischer, Rieke, Engel-Riedel, Walburga, Gautschi, Oliver, Geissinger, Eva, Haneder, Stefan, Ihle, Michaela A., Kopp, Hans-Georg, de Langen, Adrianus J., Martinez-Marti, Alex, Nogova, Lucia, Persigehl, Thorsten, Plenker, Dennis, Puesken, Michael, Rodermann, Ernst, Rosenwald, Andreas, Scheel, Andreas H., Scheffler, Matthias, Spengler, Werner, Seggewiss-Bernhardt, Ruth, Brägelmann, Johannes, Sebastian, Martin, Vrugt, Bart, Hellmich, Martin, Sos, Martin L., Heukamp, Lukas C., Felip, Enriqueta, Merkelbach-Bruse, Sabine, Smit, Egbert F., Büttner, Reinhard, Wolf, Jürgen
Publicado 2019