Special Issue: Adenosine Receptors

por Ciruela, Francisco, Sotelo, Eddy
Publicado 2017

Free-Energy Calculations for Bioisosteric Modifications of A(3) Adenosine Receptor Antagonists

por Jandova, Zuzana, Jespers, Willem, Sotelo, Eddy, Gutiérrez-de-Terán, Hugo, Oostenbrink, Chris
Publicado 2019

Synthesis and Characterization of a New Bivalent Ligand Combining Caffeine and Docosahexaenoic Acid

por Fernández-Dueñas, Víctor, Azuaje, Jhonny, Morató, Xavier, Cordobilla, Begoña, Domingo, Joan Carles, Sotelo, Eddy, Ciruela, Francisco
Publicado 2017

Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors

por Jespers, Willem, Oliveira, Ana, Prieto-Díaz, Rubén, Majellaro, María, Åqvist, Johan, Sotelo, Eddy, Gutiérrez-de-Terán, Hugo
Publicado 2017

Multicomponent Reaction-Assisted Drug Discovery: A Time- and Cost-Effective Green Approach Speeding Up Identification and Optimization of Anticancer Drugs

por Graziano, Giovanni, Stefanachi, Angela, Contino, Marialessandra, Prieto-Díaz, Rubén, Ligresti, Alessia, Kumar, Poulami, Scilimati, Antonio, Sotelo, Eddy, Leonetti, Francesco
Publicado 2023

Fluorescence based HTS-compatible ligand binding assays for dopamine D(3) receptors in baculovirus preparations and live cells

por Tahk, Maris-Johanna, Laasfeld, Tõnis, Meriste, Elo, Brea, Jose, Loza, Maria Isabel, Majellaro, Maria, Contino, Marialessandra, Sotelo, Eddy, Rinken, Ago
Publicado 2023

Deciphering conformational selectivity in the A(2A) adenosine G protein-coupled receptor by free energy simulations

por Jespers, Willem, Heitman, Laura H., IJzerman, Adriaan P., Sotelo, Eddy, van Westen, Gerard J. P., Åqvist, Johan, Gutiérrez-de-Terán, Hugo
Publicado 2021

Computer-aided design of multi-target ligands at A(1)R, A(2A)R and PDE10A, key proteins in neurodegenerative diseases

por Kalash, Leen, Val, Cristina, Azuaje, Jhonny, Loza, María I., Svensson, Fredrik, Zoufir, Azedine, Mervin, Lewis, Ladds, Graham, Brea, José, Glen, Robert, Sotelo, Eddy, Bender, Andreas
Publicado 2017

Identification of V6.51L as a selectivity hotspot in stereoselective A(2B) adenosine receptor antagonist recognition

por Wang, Xuesong, Jespers, Willem, Prieto-Díaz, Rubén, Majellaro, Maria, IJzerman, Adriaan P., van Westen, Gerard J. P., Sotelo, Eddy, Heitman, Laura H., Gutiérrez-de-Terán, Hugo
Publicado 2021

Development of Fluorescent 4-[4-(3H-Spiro[isobenzofuran-1,4′-piperidin]-1′-yl)butyl]indolyl Derivatives as High-Affinity Probes to Enable the Study of σ Receptors via Fluorescence-...

por Abatematteo, Francesca Serena, Majellaro, Maria, Montsch, Bianca, Prieto-Díaz, Rubén, Niso, Mauro, Contino, Marialessandra, Stefanachi, Angela, Riganti, Chiara, Mangiatordi, Giuseppe Felice, Delre, Pietro, Heffeter, Petra, Sotelo, Eddy, Abate, Carmen
Publicado 2023

Potent and Subtype-Selective Dopamine D(2) Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach

por Mallo-Abreu, Ana, Reyes-Resina, Irene, Azuaje, Jhonny, Franco, Rafael, García-Rey, Aitor, Majellaro, Maria, Miranda-Pastoriza, Darío, García-Mera, Xerardo, Jespers, Willem, Gutiérrez-de-Terán, Hugo, Navarro, Gemma, Sotelo, Eddy
Publicado 2021

Development of Fluorescent Probes that Target Serotonin 5-HT(2B) Receptors

por Azuaje, Jhonny, López, Paula, Iglesias, Alba, de la Fuente, Rocío A., Pérez-Rubio, José M., García, Diego, Stępniewski, Tomasz Maciej, García-Mera, Xerardo, Brea, José M., Selent, Jana, Pérez, Dolores, Castro, Marián, Loza, María I., Sotelo, Eddy
Publicado 2017

X‐Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A(2A) Adenosine Receptor Antagonists

por Jespers, Willem, Verdon, Grégory, Azuaje, Jhonny, Majellaro, Maria, Keränen, Henrik, García‐Mera, Xerardo, Congreve, Miles, Deflorian, Francesca, de Graaf, Chris, Zhukov, Andrei, Doré, Andrew S., Mason, Jonathan S., Åqvist, Johan, Cooke, Robert M., Sotelo, Eddy, Gutiérrez‐de‐Terán, Hugo
Publicado 2020

Exploring Non-orthosteric Interactions with a Series of Potent and Selective A(3) Antagonists

por Miranda-Pastoriza, Darío, Bernárdez, Rodrigo, Azuaje, Jhonny, Prieto-Díaz, Rubén, Majellaro, Maria, Tamhankar, Ashish V., Koenekoop, Lucien, González, Alejandro, Gioé-Gallo, Claudia, Mallo-Abreu, Ana, Brea, José, Loza, M. Isabel, García-Rey, Aitor, García-Mera, Xerardo, Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022

Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A(1) Antagonists

por Val, Cristina, Rodríguez-García, Carlos, Prieto-Díaz, Rubén, Crespo, Abel, Azuaje, Jhonny, Carbajales, Carlos, Majellaro, Maria, Díaz-Holguín, Alejandro, Brea, José M., Loza, Maria Isabel, Gioé-Gallo, Claudia, Contino, Marialessandra, Stefanachi, Angela, García-Mera, Xerardo, Estévez, Juan C., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022

A(2B) adenosine receptor antagonists rescue lymphocyte activity in adenosine-producing patient-derived cancer models

por Tay, Apple Hui Min, Prieto-Díaz, Rubén, Neo, Shiyong, Tong, Le, Chen, Xinsong, Carannante, Valentina, Önfelt, Björn, Hartman, Johan, Haglund, Felix, Majellaro, Maria, Azuaje, Jhonny, Garcia-Mera, Xerardo, Brea, Jose M, Loza, Maria I, Jespers, Willem, Gutierrez-de-Teran, Hugo, Sotelo, Eddy, Lundqvist, Andreas
Publicado 2022

Exploring the Effect of Halogenation in a Series of Potent and Selective A(2B) Adenosine Receptor Antagonists

por Prieto-Díaz, Rubén, González-Gómez, Manuel, Fojo-Carballo, Hugo, Azuaje, Jhonny, El Maatougui, Abdelaziz, Majellaro, Maria, Loza, María I., Brea, José, Fernández-Dueñas, Víctor, Paleo, M. Rita, Díaz-Holguín, Alejandro, Garcia-Pinel, Beatriz, Mallo-Abreu, Ana, Estévez, Juan C., Andújar-Arias, Antonio, García-Mera, Xerardo, Gomez-Tourino, Iria, Ciruela, Francisco, Salas, Cristian O., Gutiérrez-de-Terán, Hugo, Sotelo, Eddy
Publicado 2022