Enhanced proofreading governs CRISPR-Cas9 targeting accuracy

por Chen, Janice S., Dagdas, Yavuz S., Kleinstiver, Benjamin P., Welch, Moira M., Sousa, Alexander A., Harrington, Lucas B., Sternberg, Samuel H., Joung, J. Keith, Yildiz, Ahmet, Doudna, Jennifer A.
Publicado 2017

Search-and-replace genome editing without double-strand breaks or donor DNA

por Anzalone, Andrew V., Randolph, Peyton B., Davis, Jessie R., Sousa, Alexander A., Koblan, Luke W., Levy, Jonathan M., Chen, Peter J., Wilson, Christopher, Newby, Gregory A., Raguram, Aditya, Liu, David R.
Publicado 2019

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

por Kleinstiver, Benjamin P., Sousa, Alexander A., Walton, Russell T., Tak, Y. Esther, Hsu, Jonathan Y., Clement, Kendell, Welch, Moira M., Horng, Joy E., Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V., Pinello, Luca, Aryee, Martin J., Joung, J. Keith
Publicado 2019

Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications

por Friedland, Ari E., Baral, Reshica, Singhal, Pankhuri, Loveluck, Katherine, Shen, Shen, Sanchez, Minerva, Marco, Eugenio, Gotta, Gregory M., Maeder, Morgan L., Kennedy, Edward M., Kornepati, Anand V. R., Sousa, Alexander, Collins, McKensie A., Jayaram, Hari, Cullen, Bryan R., Bumcrot, David
Publicado 2015

Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

por Everette, Kelcee A., Newby, Gregory A., Levine, Rachel M., Mayberry, Kalin, Jang, Yoonjeong, Mayuranathan, Thiyagaraj, Nimmagadda, Nikitha, Dempsey, Erin, Li, Yichao, Bhoopalan, Senthil Velan, Liu, Xiong, Davis, Jessie R., Nelson, Andrew T., Chen, Peter J., Sousa, Alexander A., Cheng, Yong, Tisdale, John F., Weiss, Mitchell J., Yen, Jonathan S., Liu, David R.
Publicado 2023

High levels of AAV vector integration into CRISPR-induced DNA breaks

por Hanlon, Killian S., Kleinstiver, Benjamin P., Garcia, Sara P., Zaborowski, Mikołaj P., Volak, Adrienn, Spirig, Stefan E., Muller, Alissa, Sousa, Alexander A., Tsai, Shengdar Q., Bengtsson, Niclas E., Lööv, Camilla, Ingelsson, Martin, Chamberlain, Jeffrey S., Corey, David P., Aryee, Martin J., Joung, J. Keith, Breakefield, Xandra O., Maguire, Casey A., György, Bence
Publicado 2019