Deconstructing the Translational Tower of Babel

por Austin, Christopher P., Colvis, Christine M., Southall, Noel T.
Publicado 2018

High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington’s Disease Model

por Titus, Steven A, Southall, Noel, Marugan, Juan, Austin, Christopher P, Zheng, Wei
Publicado 2012

Collaborative Use Repurposing Engine (CURE): FDA-NCATS/NIH Effort to Capture the Global Clinical Experience of Drug Repurposing to Facilitate Development of New Treatments for Negl...

por Stone, Heather, Sacks, Leonard, Tiernan, Rosemary, Duggal, Mili, Sheils, Timothy, Southall, Noel
Publicado 2017

546. Capturing Clinician’s Experiences Repurposing Drugs to Inform Future Studies During COVID-19

por Duggal, Mili, Stone, Heather, Paul, Parvesh, Charles, Reema, Sacks, Leonard, Southall, Noel
Publicado 2020

An integrative knowledge graph for rare diseases, derived from the Genetic and Rare Diseases Information Center (GARD)

por Zhu, Qian, Nguyen, Dac-Trung, Grishagin, Ivan, Southall, Noel, Sid, Eric, Pariser, Anne
Publicado 2020

COPI Complex Is a Regulator of Lipid Homeostasis

por Beller, Mathias, Sztalryd, Carole, Southall, Noel, Bell, Ming, Jäckle, Herbert, Auld, Douglas S, Oliver, Brian
Publicado 2008

Comparison on Functional Assays for Gq-Coupled GPCRs by Measuring Inositol Monophospate-1 and Intracellular Calcium in 1536-Well Plate Format

por Liu, Ke, Titus, Steve, Southall, Noel, Zhu, Pingjun, Inglese, James, Austin, Christopher P, Zheng, Wei
Publicado 2008

High Throughput Screening for Inhibitors of Alpha-Galactosidase

por Motabar, Omid, Liu, Ke, Southall, Noel, Marugan, Juan J, Goldin, Ehud, Sidransky, Ellen, Zheng, Wei
Publicado 2010

Predicting liver cytosol stability of small molecules

por Shah, Pranav, Siramshetty, Vishal B., Zakharov, Alexey V., Southall, Noel T., Xu, Xin, Nguyen, Dac-Trung
Publicado 2020

High Throughput Screening for Small Molecule Therapy for Gaucher Disease Using Patient Tissue as the Source of Mutant Glucocerebrosidase

por Goldin, Ehud, Zheng, Wei, Motabar, Omid, Southall, Noel, Choi, Jae Hyuk, Marugan, Juan, Austin, Christopher P., Sidransky, Ellen
Publicado 2012

Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding

por Huang, Bill X., Hu, Xin, Kwon, Heung-Sun, Fu, Cheng, Lee, Ji-Won, Southall, Noel, Marugan, Juan, Kim, Hee-Yong
Publicado 2020

Novel Patient Cell-Based HTS Assay for Identification of Small Molecules for a Lysosomal Storage Disease

por Geng, Haifeng, Whiteley, Grace, Ribbens, Jameson, Zheng, Wei, Southall, Noel, Hu, Xin, Marugan, Juan J., Ferrer, Marc, Maegawa, Gustavo H. B.
Publicado 2011

High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1

por Wang, Mengqiao, Xu, Miao, Long, Yan, Fargue, Sonia, Southall, Noel, Hu, Xin, McKew, John C., Danpure, Christopher J., Zheng, Wei
Publicado 2016

A Homogenous Luminescence Assay Reveals Novel Inhibitors for Giardia Lamblia Carbamate Kinase

por Chen, Catherine Z, Southall, Noel, Galkin, Andrey, Lim, Kap, Marugan, Juan J, Kulakova, Liudmila, Shinn, Paul, van Leer, Danielle, Zheng, Wei, Herzberg, Osnat
Publicado 2012

Comprehensive Characterization of Cytochrome P450 Isozyme Selectivity across Chemical Libraries

por Veith, Henrike, Southall, Noel, Huang, Ruili, James, Tim, Fayne, Darren, Artemenko, Natalia, Shen, Min, Inglese, James, Austin, Christopher P., Lloyd, David G., Auld, Douglas S.
Publicado 2009

Inhibition of Ceramide Metabolism Sensitizes Human Leukemia Cells to Inhibition of BCL2-Like Proteins

por Casson, Lavona, Howell, Lauren, Mathews, Lesley A., Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan M., Thomas, Craig, Siskind, Leah J., Beverly, Levi J.
Publicado 2013

High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress

por Thorne, Natasha, Malik, Nasir, Shah, Sonia, Zhao, Jean, Class, Bradley, Aguisanda, Francis, Southall, Noel, Xia, Menghang, McKew, John C., Rao, Mahendra, Zheng, Wei
Publicado 2016

Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria

por Sun, Wei, Weingarten, Rebecca A, Xu, Miao, Southall, Noel, Dai, Sheng, Shinn, Paul, Sanderson, Philip E, Williamson, Peter R, Frank, Karen M, Zheng, Wei
Publicado 2016

Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt

por Huang, Bill X., Newcomer, Kenny, Kevala, Karl, Barnaeva, Elena, Zheng, Wei, Hu, Xin, Patnaik, Samarjit, Southall, Noel, Marugan, Juan, Ferrer, Marc, Kim, Hee-Yong
Publicado 2017

The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases – recommendations of the IRDiRC Data Mining...

por Southall, Noel T, Natarajan, Madhusudan, Lau, Lilian Pek Lian, Jonker, Anneliene Hechtelt, Deprez, Benoît, Guilliams, Tim, Hunter, Lawrence, Rademaker, Carin MA, Hivert, Virginie, Ardigò, Diego
Publicado 2019