A Computational Model of a Microfluidic Device to Measure the Dynamics of Oxygen-Dependent ATP Release from Erythrocytes

por Sove, Richard J., Ghonaim, Nour, Goldman, Daniel, Ellis, Christopher Gerald
Publicado 2013

Finite Element Model of Oxygen Transport for the Design of Geometrically Complex Microfluidic Devices Used in Biological Studies

por Sové, Richard J., Fraser, Graham M., Goldman, Daniel, Ellis, Christopher G.
Publicado 2016

Quantitative systems pharmacology model predictions for efficacy of atezolizumab and nab-paclitaxel in triple-negative breast cancer

por Wang, Hanwen, Ma, Huilin, Sové, Richard J, Emens, Leisha A, Popel, Aleksander S
Publicado 2021

Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model

por Ma, Huilin, Wang, Hanwen, Sové, Richard J, Wang, Jun, Giragossian, Craig, Popel, Aleksander S
Publicado 2020

QSP‐IO: A Quantitative Systems Pharmacology Toolbox for Mechanistic Multiscale Modeling for Immuno‐Oncology Applications

por Sové, Richard J., Jafarnejad, Mohammad, Zhao, Chen, Wang, Hanwen, Ma, Huilin, Popel, Aleksander S.
Publicado 2020

A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization

por Zhao, Chen, Medeiros, Thalyta X., Sové, Richard J., Annex, Brian H., Popel, Aleksander S.
Publicado 2021

Virtual clinical trials of anti-PD-1 and anti-CTLA-4 immunotherapy in advanced hepatocellular carcinoma using a quantitative systems pharmacology model

por Sové, Richard J, Verma, Babita K, Wang, Hanwen, Ho, Won Jin, Yarchoan, Mark, Popel, Aleksander S
Publicado 2022

A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology

por Zhao, Chen, Mirando, Adam C., Sové, Richard J., Medeiros, Thalyta X., Annex, Brian H., Popel, Aleksander S.
Publicado 2019

Simulations of tumor growth and response to immunotherapy by coupling a spatial agent-based model with a whole-patient quantitative systems pharmacology model

por Ruiz-Martinez, Alvaro, Gong, Chang, Wang, Hanwen, Sové, Richard J., Mi, Haoyang, Kimko, Holly, Popel, Aleksander S.
Publicado 2022

Localized Oxygen Exchange Platform for Intravital Video Microscopy Investigations of Microvascular Oxygen Regulation

por Sové, Richard J., Milkovich, Stephanie, Nikolov, Hristo N., Holdsworth, David W., Ellis, Christopher G., Fraser, Graham M.
Publicado 2021

A Quantitative Systems Pharmacology Model of T Cell Engager Applied to Solid Tumor

por Ma, Huilin, Wang, Hanwen, Sove, Richard J., Jafarnejad, Mohammad, Tsai, Chia-Hung, Wang, Jun, Giragossian, Craig, Popel, Aleksander S.
Publicado 2020

Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model

por Kowalewska, Paulina M., Kowalewski, Justin E., Milkovich, Stephanie L., Sové, Richard J., Wang, Lin, Whitehead, Shawn N., Ellis, Christopher G.
Publicado 2022

Conducting a Virtual Clinical Trial in HER2-Negative Breast Cancer Using a Quantitative Systems Pharmacology Model With an Epigenetic Modulator and Immune Checkpoint Inhibitors

por Wang, Hanwen, Sové, Richard J., Jafarnejad, Mohammad, Rahmeh, Sondra, Jaffee, Elizabeth M., Stearns, Vered, Torres, Evanthia T. Roussos, Connolly, Roisin M., Popel, Aleksander S.
Publicado 2020

Mechanistically detailed systems biology modeling of the HGF/Met pathway in hepatocellular carcinoma

por Jafarnejad, Mohammad, Sové, Richard J., Danilova, Ludmila, Mirando, Adam C., Zhang, Yu, Yarchoan, Mark, Tran, Phuoc T., Pandey, Niranjan B., Fertig, Elana J., Popel, Aleksander S.
Publicado 2019