Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra®, R115777) in combination with gemcitabine and cisplatin in patients with advanced soli...

por Siegel-Lakhai, W S, Crul, M, Zhang, S, Sparidans, R W, Pluim, D, Howes, A, Solanki, B, Beijnen, J H, Schellens, J H M
Publicado 2005

PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model

por van Bavel, J. J. A., Pham, C., Beekman, H. D. M., Houtman, M. J. C., Bossu, A., Sparidans, R. W., van der Heyden, M. A. G., Vos, M. A.
Publicado 2022