Onchocerciasis drug development: from preclinical models to humans

por Ngwewondo, Adela, Scandale, Ivan, Specht, Sabine
Publicado 2021

River blindness: reducing the prevalence of clinical disease

por Mackenzie, Charles, Kollmann, Martin, Specht, Sabine, Sodhalon, Yao
Publicado 2018

Elimination of lymphatic filariasis in South East Asia

por Specht, Sabine, Suma, T K, Pedrique, Belen, Hoerauf, Achim
Publicado 2019

Criteria for the differentiation between young and old Onchocerca volvulus filariae

por Specht, Sabine, Brattig, Norbert, Büttner, Marcelle, Büttner, Dietrich W.
Publicado 2009

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

por Specht, Sabine, Hoerauf, Achim, Adjei, Ohene, Debrah, Alexander, Büttner, Dietrich W.
Publicado 2009

Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review

por Palmeirim, Marta S., Specht, Sabine, Scandale, Ivan, Gander-Meisterernst, Irene, Chabicovsky, Monika, Keiser, Jennifer
Publicado 2021

Drug development for the treatment of onchocerciasis: Population pharmacokinetic and adverse events modeling of emodepside

por Assmus, Frauke, Hoglund, Richard M., Monnot, Frédéric, Specht, Sabine, Scandale, Ivan, Tarning, Joel
Publicado 2022

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

por Walker, Martin, Specht, Sabine, Churcher, Thomas S., Hoerauf, Achim, Taylor, Mark J., Basáñez, María-Gloria
Publicado 2015

Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis

por Ziewer, Sebastian, Hübner, Marc P., Dubben, Bettina, Hoffmann, Wolfgang H., Bain, Odile, Martin, Coralie, Hoerauf, Achim, Specht, Sabine
Publicado 2012

The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization

por Tendongfor, Nicholas, Wanji, Samuel, Ngwa, Julius C, Esum, Mathias E, Specht, Sabine, Enyong, Peter, Matthaei, Klaus I, Hoerauf, Achim
Publicado 2012

Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses

por Ehlen, Lukas, Tödtmann, Jan, Specht, Sabine, Kallies, René, Papies, Jan, Müller, Marcel A., Junglen, Sandra, Drosten, Christian, Eckerle, Isabella
Publicado 2016

Leukocyte-Derived Interleukin-10 Aggravates Postoperative Ileus

por Stein, Kathy, Lysson, Mariola, Schumak, Beatrix, Vilz, Tim, Specht, Sabine, Heesemann, Jürgen, Roers, Axel, Kalff, Jörg C., Wehner, Sven
Publicado 2018

Supporting Drug Development for Neglected Tropical Diseases Using Mathematical Modeling

por Walker, Martin, Hamley, Jonathan I D, Milton, Philip, Monnot, Frédéric, Kinrade, Sally, Specht, Sabine, Pedrique, Bélen, Basáñez, Maria-Gloria
Publicado 2021

In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase

por Kusch, Peter, Deininger, Susanne, Specht, Sabine, Maniako, Rudeka, Haubrich, Stefanie, Pommerening, Tanja, Lin, Paul Kong Thoo, Hoerauf, Achim, Kaiser, Annette
Publicado 2011

Repurposing of approved drugs from the human pharmacopoeia to target Wolbachia endosymbionts of onchocerciasis and lymphatic filariasis

por Johnston, Kelly L., Ford, Louise, Umareddy, Indira, Townson, Simon, Specht, Sabine, Pfarr, Kenneth, Hoerauf, Achim, Altmeyer, Ralf, Taylor, Mark J.
Publicado 2014

NOD2 dependent neutrophil recruitment is required for early protective immune responses against infectious Litomosoides sigmodontis L3 larvae

por Ajendra, Jesuthas, Specht, Sabine, Ziewer, Sebastian, Schiefer, Andrea, Pfarr, Kenneth, Parčina, Marijo, Kufer, Thomas A., Hoerauf, Achim, Hübner, Marc P.
Publicado 2016

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung

por Karadjian, Gregory, Fercoq, Frédéric, Pionnier, Nicolas, Vallarino-Lhermitte, Nathaly, Lefoulon, Emilie, Nieguitsila, Adélaïde, Specht, Sabine, Carlin, Leo M., Martin, Coralie
Publicado 2017

Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals

por Arndts, Kathrin, Klarmann-Schulz, Ute, Batsa, Linda, Debrah, Alexander Y, Epp, Christian, Fimmers, Rolf, Specht, Sabine, Layland, Laura E, Hoerauf, Achim
Publicado 2015

Macrofilaricidal Activity in Wuchereria bancrofti after 2 Weeks Treatment with a Combination of Rifampicin plus Doxycycline

por Debrah, Alexander Yaw, Mand, Sabine, Marfo-Debrekyei, Yeboah, Batsa, Linda, Albers, Anna, Specht, Sabine, Klarmann, Ute, Pfarr, Kenneth, Adjei, Ohene, Hoerauf, Achim
Publicado 2011

Analysis of Nematode Motion Using an Improved Light-Scatter Based System

por Nutting, Chuck S., Eversole, Rob R., Blair, Kevin, Specht, Sabine, Nutman, Thomas B., Klion, Amy D., Wanji, Samuel, Boussinesq, Michel, Mackenzie, Charles D.
Publicado 2015