RUNX1 Mutations in Inherited and Sporadic Leukemia

por Bellissimo, Dana C., Speck, Nancy A.
Publicado 2017

Runx1 is required for the endothelial to hematopoietic cell transition but not thereafter

por Chen, Michael J., Yokomizo, Tomomasa, Zeigler, Brandon, Dzierzak, Elaine, Speck, Nancy A.
Publicado 2009

A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails

por Tang, Shaohua, Xu, Qiyu, Xu, Xueqin, Du, Jicheng, Yang, Xuemei, Jiang, Yusheng, Wang, Xiaoqin, Speck, Nancy, Huang, Taosheng
Publicado 2007

DNA Specificity Determinants Associate with Distinct Transcription Factor Functions

por Hollenhorst, Peter C., Chandler, Katherine J., Poulsen, Rachel L., Johnson, W. Evan, Speck, Nancy A., Graves, Barbara J.
Publicado 2009

Loss of neurofibromin Ras-GAP activity enhances the formation of cardiac blood islands in murine embryos

por Yzaguirre, Amanda D, Padmanabhan, Arun, de Groh, Eric D, Engleka, Kurt A, Li, Jun, Speck, Nancy A, Epstein, Jonathan A
Publicado 2015

Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes

por Howell, Elizabeth D., Yzaguirre, Amanda D., Gao, Peng, Lis, Raphael, He, Bing, Lakadamyali, Melike, Rafii, Shahin, Tan, Kai, Speck, Nancy A.
Publicado 2021

Runx1 Loss Minimally Impacts Long-Term Hematopoietic Stem Cells

por Cai, Xiongwei, Gaudet, Justin J., Mangan, James K., Chen, Michael J., De Obaldia, Maria Elena, Oo, Zaw, Ernst, Patricia, Speck, Nancy A.
Publicado 2011

Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells

por Chen, Changya, Yu, Wenbao, Tober, Joanna, Gao, Peng, He, Bing, Lee, Kiwon, Trieu, Tuan, Blobel, Gerd A., Speck, Nancy A., Tan, Kai
Publicado 2019

Maturation of hematopoietic stem cells from prehematopoietic stem cells is accompanied by up-regulation of PD-L1

por Tober, Joanna, Maijenburg, Marijke M.W., Li, Yan, Gao, Long, Hadland, Brandon K., Gao, Peng, Minoura, Kodai, Bernstein, Irwin D., Tan, Kai, Speck, Nancy A.
Publicado 2018

Enhancing Hematopoiesis from Murine Embryonic Stem Cells through MLL1-Induced Activation of a Rac/Rho/Integrin Signaling Axis

por Yang, Weiwei, Trahan, G. Devon, Howell, Elizabeth D., Speck, Nancy A., Jones, Kenneth L., Gillen, Austin E., Riemondy, Kent, Hesselberth, Jay, Bryder, David, Ernst, Patricia
Publicado 2020

Gata2 is required for HSC generation and survival

por de Pater, Emma, Kaimakis, Polynikis, Vink, Chris S., Yokomizo, Tomomasa, Yamada-Inagawa, Tomoko, van der Linden, Reinier, Kartalaei, Parham Solaimani, Camper, Sally A., Speck, Nancy, Dzierzak, Elaine
Publicado 2013

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells

por Gao, Peng, Chen, Changya, Howell, Elizabeth D., Li, Yan, Tober, Joanna, Uzun, Yasin, He, Bing, Gao, Long, Zhu, Qin, Siekmann, Arndt F., Speck, Nancy A., Tan, Kai
Publicado 2020

Rb family proteins enforce the homeostasis of quiescent hematopoietic stem cells by repressing Socs3 expression

por Kim, Eunsun, Cheng, Ying, Bolton-Gillespie, Elisabeth, Cai, Xiongwei, Ma, Connie, Tarangelo, Amy, Le, Linh, Jambhekar, Madhumita, Raman, Pichai, Hayer, Katharina E., Wertheim, Gerald, Speck, Nancy A., Tong, Wei, Viatour, Patrick
Publicado 2017

HUMAN DEFINITIVE HAEMOGENIC ENDOTHELIUM AND ARTERIAL VASCULAR ENDOTHELIUM REPRESENT DISTINCT LINEAGES

por Ditadi, Andrea, Sturgeon, Christopher M., Tober, Joanna, Awong, Geneve, Kennedy, Marion, Phillips, Amanda, Azzola, Lisa, Ng, Elizabeth S., Stanley, Edouard, French, Deborah L., Cheng, Xin, Gadue, Paul, Speck, Nancy, Elefanty, Andrew G., Keller, Gordon
Publicado 2015

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis

por Wilken, Madison B, Fonar, Gennadiy, Nations, Catriana, Pavani, Giulia, Tsao, Victor, Garifallou, James, Tober, Joanna, Bennett, Laura, Maguire, Jean Ann, Gagne, Alyssa, Okoli, Nkemdilim, Gadue, Paul, Chou, Stella T, Speck, Nancy A, French, Deborah L, Thom, Christopher S
Publicado 2023

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD

por Ernst, Martijn P. T., Pronk, Eline, van Dijk, Claire, van Strien, Paulina M. H., van Tienhoven, Tim V. D., Wevers, Michiel J. W., Sanders, Mathijs A., Bindels, Eric M. J., Speck, Nancy A., Raaijmakers, Marc H. G. P.
Publicado 2023

Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production

por Li, Yan, Esain, Virginie, Teng, Li, Xu, Jian, Kwan, Wanda, Frost, Isaura M., Yzaguirre, Amanda D., Cai, Xiongwei, Cortes, Mauricio, Maijenburg, Marijke W., Tober, Joanna, Dzierzak, Elaine, Orkin, Stuart H., Tan, Kai, North, Trista E., Speck, Nancy A.
Publicado 2014

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells

por Gerhardt, Dawson M., Pajcini, Kostandin V., D’altri, Teresa, Tu, LiLi, Jain, Rajan, Xu, Lanwei, Chen, Michael J., Rentschler, Stacey, Shestova, Olga, Wertheim, Gerald B., Tobias, John W., Kluk, Michael, Wood, Antony W., Aster, Jon C., Gimotty, Phyllis A., Epstein, Jonathan A., Speck, Nancy, Bigas, Anna, Pear, Warren S.
Publicado 2014