Let's make it clear: systematic exploration of mitochondrial DNA– and RNA–protein complexes by complexome profiling

por Potter, Alisa, Cabrera-Orefice, Alfredo, Spelbrink, Johannes N
Publicado 2023

A New Splice Variant of the Mouse SIRT3 Gene Encodes the Mitochondrial Precursor Protein

por Cooper, Helen M., Huang, Jing-Yi, Verdin, Eric, Spelbrink, Johannes N.
Publicado 2009

Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication

por Rajala, Nina, Gerhold, Joachim M., Martinsson, Peter, Klymov, Alexey, Spelbrink, Johannes N.
Publicado 2014

The mitochondrial outer-membrane location of the EXD2 exonuclease contradicts its direct role in nuclear DNA repair

por Hensen, Fenna, Moretton, Amandine, van Esveld, Selma, Farge, Géraldine, Spelbrink, Johannes N.
Publicado 2018

Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes

por Wanrooij, Sjoerd, Goffart, Steffi, Pohjoismäki, Jaakko L.O., Yasukawa, Takehiro, Spelbrink, Johannes N.
Publicado 2007

Twinkle mutations associated with autosomal dominant progressive external ophthalmoplegia lead to impaired helicase function and in vivo mtDNA replication stalling

por Goffart, Steffi, Cooper, Helen M., Tyynismaa, Henna, Wanrooij, Sjoerd, Suomalainen, Anu, Spelbrink, Johannes N.
Publicado 2009

Uncharacterized protein C17orf80 – a novel interactor of human mitochondrial nucleoids

por Potter, Alisa, Hangas, Anu, Goffart, Steffi, Huynen, Martijn A., Cabrera-Orefice, Alfredo, Spelbrink, Johannes N.
Publicado 2023

Whole Cell Formaldehyde Cross-Linking Simplifies Purification of Mitochondrial Nucleoids and Associated Proteins Involved in Mitochondrial Gene Expression

por Rajala, Nina, Hensen, Fenna, Wessels, Hans J. C. T., Ives, Daniel, Gloerich, Jolein, Spelbrink, Johannes N.
Publicado 2015

Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB

por Hensen, Fenna, Potter, Alisa, van Esveld, Selma L, Tarrés-Solé, Aleix, Chakraborty, Arka, Solà, Maria, Spelbrink, Johannes N
Publicado 2019

Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells

por Pohjoismäki, Jaakko L. O., Wanrooij, Sjoerd, Hyvärinen, Anne K., Goffart, Steffi, Holt, Ian J., Spelbrink, Johannes N., Jacobs, Howard T.
Publicado 2006

A Combined Mass Spectrometry and Data Integration Approach to Predict the Mitochondrial Poly(A) RNA Interacting Proteome

por van Esveld, Selma L., Cansız-Arda, Şirin, Hensen, Fenna, van der Lee, Robin, Huynen, Martijn A., Spelbrink, Johannes N.
Publicado 2019

Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication

por Cluett, Tricia J, Akman, Gokhan, Reyes, Aurelio, Kazak, Lawrence, Mitchell, Alice, Wood, Stuart R, Spinazzola, Antonella, Spelbrink, Johannes N, Holt, Ian J
Publicado 2018

Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome

por van Esveld, Selma L., Rodenburg, Richard J., Al‐Murshedi, Fathiya, Al‐Ajmi, Eiman, Al‐Zuhaibi, Sana, Huynen, Martijn A., Spelbrink, Johannes N.
Publicado 2022

Top3α is the replicative topoisomerase in mitochondrial DNA replication

por Hangas, Anu, Kekäläinen, Nina J, Potter, Alisa, Michell, Craig, Aho, Kauko J, Rutanen, Chiara, Spelbrink, Johannes N, Pohjoismäki, Jaakko L, Goffart, Steffi
Publicado 2022

The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA

por Hyvärinen, Anne K., Pohjoismäki, Jaakko L. O., Reyes, Aurelio, Wanrooij, Sjoerd, Yasukawa, Takehiro, Karhunen, Pekka J., Spelbrink, Johannes N., Holt, Ian J., Jacobs, Howard T.
Publicado 2007

Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

por Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Publicado 2015

Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure

por Gerhold, Joachim M., Cansiz-Arda, Şirin, Lõhmus, Madis, Engberg, Oskar, Reyes, Aurelio, van Rennes, Helga, Sanz, Alberto, Holt, Ian J., Cooper, Helen M., Spelbrink, Johannes N.
Publicado 2015

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing

por Tesori, Valentina, Piscaglia, Anna Chiara, Samengo, Daniela, Barba, Marta, Bernardini, Camilla, Scatena, Roberto, Pontoglio, Alessandro, Castellini, Laura, Spelbrink, Johannes N., Maulucci, Giuseppe, Puglisi, Maria Ausiliatrice, Pani, Giovambattista, Gasbarrini, Antonio
Publicado 2015

The hexameric structure of the human mitochondrial replicative helicase Twinkle

por Fernández-Millán, Pablo, Lázaro, Melisa, Cansız-Arda, Şirin, Gerhold, Joachim M., Rajala, Nina, Schmitz, Claus-A., Silva-Espiña, Cristina, Gil, David, Bernadó, Pau, Valle, Mikel, Spelbrink, Johannes N., Solà, Maria
Publicado 2015

Analysis of 953 Human Proteins from a Mitochondrial HEK293 Fraction by Complexome Profiling

por Wessels, Hans J. C. T., Vogel, Rutger O., Lightowlers, Robert N., Spelbrink, Johannes N., Rodenburg, Richard J., van den Heuvel, Lambert P., van Gool, Alain J., Gloerich, Jolein, Smeitink, Jan A. M., Nijtmans, Leo G.
Publicado 2013