Perturbation of TM6SF2 Expression Alters Lipid Metabolism in a Human Liver Cell Line

por Pant, Asmita, Chen, Yue, Kuppa, Annapurna, Du, Xiaomeng, Halligan, Brian D., Speliotes, Elizabeth K.
Publicado 2021

Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease

por Maguire, Lillias H., Handelman, Samuel K., Du, Xiaomeng, Chen, Yanhua, Pers, Tune H., Speliotes, Elizabeth K.
Publicado 2018

Population‐based meta‐analysis and gene‐set enrichment identifies FXR/RXR pathway as common to fatty liver disease and serum lipids

por Handelman, Samuel K., Puentes, Yindra M., Kuppa, Annapurna, Chen, Yanhua, Du, Xiaomeng, Feitosa, Mary F., Palmer, Nicholette D., Speliotes, Elizabeth K.
Publicado 2022

Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis

por Chen, Vincent L., Wright, Andrew P., Halligan, Brian, Chen, Yanhua, Du, Xiaomeng, Handelman, Samuel K., Long, Michelle T., Kiel, Douglas P., Speliotes, Elizabeth K.
Publicado 2019

Non-Alcoholic Fatty Liver Disease and Vitamin D in the UK Biobank: A Two-Sample Bidirectional Mendelian Randomisation Study

por Zhang, Zixuan, Burrows, Kimberley, Fuller, Harriett, Speliotes, Elizabeth K., Abeysekera, Kushala W. M., Thorne, James L., Lewis, Sarah J., Zulyniak, Michael A., Moore, J. Bernadette
Publicado 2023

Adipose Tissue Depots and Their Cross‐Sectional Associations With Circulating Biomarkers of Metabolic Regulation

por Lee, Jane J., Britton, Kathryn A., Pedley, Alison, Massaro, Joseph M., Speliotes, Elizabeth K., Murabito, Joanne M., Hoffmann, Udo, Ingram, Cheryl, Keaney, John F., Vasan, Ramachandran S., Fox, Caroline S.
Publicado 2016

Author Correction: Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

por Chen, Vincent L., Du, Xiaomeng, Chen, Yanhua, Kuppa, Annapurna, Handelman, Samuel K., Vohnoutka, Rishel B., Peyser, Patricia A., Palmer, Nicholette D., Bielak, Lawrence F., Halligan, Brian, Speliotes, Elizabeth K.
Publicado 2023

Genome-wide association study of serum liver enzymes implicates diverse metabolic and liver pathology

por Chen, Vincent L., Du, Xiaomeng, Chen, Yanhua, Kuppa, Annapurna, Handelman, Samuel K., Vohnoutka, Rishel B., Peyser, Patricia A., Palmer, Nicholette D., Bielak, Lawrence F., Halligan, Brian, Speliotes, Elizabeth K.
Publicado 2021

Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype

por Chen, Vincent L., Burkholder, Daniel A., Moran, Isabel J., DiBattista, Jacob V., Miller, Matthew J., Chen, Yanhua, Du, Xiaomeng, Oliveri, Antonino, Cushing, Kelly C., Lok, Anna S., Speliotes, Elizabeth K.
Publicado 2022

Genome-wide study of subcutaneous and visceral adipose tissue reveals novel sex-specific adiposity loci in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study

por Gao, Chuan, Langefeld, Carl D., Ziegler, Julie T., Taylor, Kent D., Norris, Jill M., Chen, Yii-Der I., Hellwege, Jacklyn N., Guo, Xiuqing, Allison, Matthew A., Speliotes, Elizabeth K., Rotter, Jerome I., Bowden, Donald W., Wagenknecht, Lynne E., Palmer, Nicholette D.
Publicado 2017

Genome-wide Linkage and Association Analysis of Cardiometabolic Phenotypes in Hispanic Americans

por Hellwege, Jacklyn N., Palmer, Nicholette D., Dimitrov, Latchezar, Keaton, Jacob M., Tabb, Keri L., Sajuthi, Satria, Taylor, Kent D., Ng, Maggie C.Y., Speliotes, Elizabeth K., Hawkins, Gregory A., Long, Jirong, Chen, Yii-Der Ida, Lorenzo, Carlos, Norris, Jill M., Rotter, Jerome I., Langefeld, Carl D., Wagenknecht, Lynne E., Bowden, Donald W.
Publicado 2016

A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS)

por Gao, Chuan, Wang, Nan, Guo, Xiuqing, Ziegler, Julie T., Taylor, Kent D., Xiang, Anny H., Hai, Yang, Kridel, Steven J., Nadler, Jerry L., Kandeel, Fouad, Raffel, Leslie J., Chen, Yii-Der I., Norris, Jill M., Rotter, Jerome I., Watanabe, Richard M., Wagenknecht, Lynne E., Bowden, Donald W., Speliotes, Elizabeth K., Goodarzi, Mark O., Langefeld, Carl D., Palmer, Nicholette D.
Publicado 2015

Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes

por Barata, Llilda, Feitosa, Mary F., Bielak, Lawrence F., Halligan, Brian, Baldridge, Abigail S., Guo, Xiuqing, Yerges‐Armstrong, Laura M., Smith, Albert V., Yao, Jie, Palmer, Nicholette D., VanWagner, Lisa B., Carr, J. Jeffrey, Chen, Yii‐Der I., Allison, Matthew, Budoff, Matthew J., Handelman, Samuel K., Kardia, Sharon L.R., Mosley, Thomas H., Ryan, Kathleen, Harris, Tamara B., Launer, Lenore J., Gudnason, Vilmundur, Rotter, Jerome I., Fornage, Myriam, Rasmussen‐Torvik, Laura J., Borecki, Ingrid B., O’Connell, Jeffrey R., Peyser, Patricia A., Speliotes, Elizabeth K., Province, Michael A.
Publicado 2019

Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits

por Speliotes, Elizabeth K., Yerges-Armstrong, Laura M., Wu, Jun, Hernaez, Ruben, Kim, Lauren J., Palmer, Cameron D., Gudnason, Vilmundur, Eiriksdottir, Gudny, Garcia, Melissa E., Launer, Lenore J., Nalls, Michael A., Clark, Jeanne M., Mitchell, Braxton D., Shuldiner, Alan R., Butler, Johannah L., Tomas, Marta, Hoffmann, Udo, Hwang, Shih-Jen, Massaro, Joseph M., O'Donnell, Christopher J., Sahani, Dushyant V., Salomaa, Veikko, Schadt, Eric E., Schwartz, Stephen M., Siscovick, David S., Voight, Benjamin F., Carr, J. Jeffrey, Feitosa, Mary F., Harris, Tamara B., Fox, Caroline S., Smith, Albert V., Kao, W. H. Linda, Hirschhorn, Joel N., Borecki, Ingrid B.
Publicado 2011

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

por Voight, Benjamin F., Kang, Hyun Min, Ding, Jun, Palmer, Cameron D., Sidore, Carlo, Chines, Peter S., Burtt, Noël P., Fuchsberger, Christian, Li, Yanming, Erdmann, Jeanette, Frayling, Timothy M., Heid, Iris M., Jackson, Anne U., Johnson, Toby, Kilpeläinen, Tuomas O., Lindgren, Cecilia M., Morris, Andrew P., Prokopenko, Inga, Randall, Joshua C., Saxena, Richa, Soranzo, Nicole, Speliotes, Elizabeth K., Teslovich, Tanya M., Wheeler, Eleanor, Maguire, Jared, Parkin, Melissa, Potter, Simon, Rayner, N. William, Robertson, Neil, Stirrups, Kathleen, Winckler, Wendy, Sanna, Serena, Mulas, Antonella, Nagaraja, Ramaiah, Cucca, Francesco, Barroso, Inês, Deloukas, Panos, Loos, Ruth J. F., Kathiresan, Sekar, Munroe, Patricia B., Newton-Cheh, Christopher, Pfeufer, Arne, Samani, Nilesh J., Schunkert, Heribert, Hirschhorn, Joel N., Altshuler, David, McCarthy, Mark I., Abecasis, Gonçalo R., Boehnke, Michael
Publicado 2012

Correction: The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

por Voight, Benjamin F., Kang, Hyun Min, Ding, Jun, Palmer, Cameron D., Sidore, Carlo, Chines, Peter S., Burtt, Noël P., Fuchsberger, Christian, Li, Yanming, Erdmann, Jeanette, Frayling, Timothy M., Heid, Iris M., Jackson, Anne U., Johnson, Toby, Kilpeläinen, Tuomas O., Lindgren, Cecilia M., Morris, Andrew P., Prokopenko, Inga, Randall, Joshua C., Saxena, Richa, Soranzo, Nicole, Speliotes, Elizabeth K., Teslovich, Tanya M., Wheeler, Eleanor, Maguire, Jared, Parkin, Melissa, Potter, Simon, Rayner, N. William, Robertson, Neil, Stirrups, Kathleen, Winckler, Wendy, Sanna, Serena, Mulas, Antonella, Nagaraja, Ramaiah, Cucca, Francesco, Barroso, Inês, Deloukas, Panos, Loos, Ruth J. F., Kathiresan, Sekar, Munroe, Patricia B., Newton-Cheh, Christopher, Pfeufer, Arne, Samani, Nilesh J., Schunkert, Heribert, Hirschhorn, Joel N., Altshuler, David, McCarthy, Mark I., Abecasis, Gonçalo R., Boehnke, Michael
Publicado 2013

rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis

por Teo, Kevin, Abeysekera, Kushala W.M., Adams, Leon, Aigner, Elmar, Anstee, Quentin M., Banales, Jesus M., Banerjee, Rajarshi, Basu, Priyadarshi, Berg, Thomas, Bhatnagar, Pallav, Buch, Stephan, Canbay, Ali, Caprio, Sonia, Chatterjee, Ankita, Ida Chen, Yii-Der, Chowdhury, Abhijit, Daly, Ann K., Datz, Christian, de Gracia Hahn, Dana, DiStefano, Johanna K., Dong, Jiawen, Duret, Amedine, Emdin, Connor, Fairey, Madison, Gerhard, Glenn S., Guo, Xiuqing, Hampe, Jochen, Hickman, Matthew, Heintz, Lena, Hudert, Christian, Hunter, Harriet, Kelly, Matt, Kozlitina, Julia, Krawczyk, Marcin, Lammert, Frank, Langenberg, Claudia, Lavine, Joel, Li, Lin, Lim, Hong Kai, Loomba, Rohit, Luukkonen, Panu K., Melton, Phillip E., Mori, Trevor A., Palmer, Nicholette D., Parisinos, Constantinos A., Pillai, Sreekumar G., Qayyum, Faiza, Reichert, Matthias C., Romeo, Stefano, Rotter, Jerome I., Im, Yu Ri, Santoro, Nicola, Schafmayer, Clemens, Speliotes, Elizabeth K., Stender, Stefan, Stickel, Felix, Still, Christopher D., Strnad, Pavel, Taylor, Kent D., Tybjærg-Hansen, Anne, Umano, Giuseppina Rosaria, Utukuri, Mrudula, Valenti, Luca, Wagenknecht, Lynne E., Wareham, Nicholas J., Watanabe, Richard M., Wattacheril, Julia, Yaghootkar, Hanieh, Yki-Järvinen, Hannele, Young, Kendra A., Mann, Jake P.
Publicado 2021

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

por Liu, Ching-Ti, Monda, Keri L., Taylor, Kira C., Lange, Leslie, Demerath, Ellen W., Palmas, Walter, Wojczynski, Mary K., Ellis, Jaclyn C., Vitolins, Mara Z., Liu, Simin, Papanicolaou, George J., Irvin, Marguerite R., Xue, Luting, Griffin, Paula J., Nalls, Michael A., Adeyemo, Adebowale, Liu, Jiankang, Li, Guo, Ruiz-Narvaez, Edward A., Chen, Wei-Min, Chen, Fang, Henderson, Brian E., Millikan, Robert C., Ambrosone, Christine B., Strom, Sara S., Guo, Xiuqing, Andrews, Jeanette S., Sun, Yan V., Mosley, Thomas H., Yanek, Lisa R., Shriner, Daniel, Haritunians, Talin, Rotter, Jerome I., Speliotes, Elizabeth K., Smith, Megan, Rosenberg, Lynn, Mychaleckyj, Josyf, Nayak, Uma, Spruill, Ida, Garvey, W. Timothy, Pettaway, Curtis, Nyante, Sarah, Bandera, Elisa V., Britton, Angela F., Zonderman, Alan B., Rasmussen-Torvik, Laura J., Chen, Yii-Der Ida, Ding, Jingzhong, Lohman, Kurt, Kritchevsky, Stephen B., Zhao, Wei, Peyser, Patricia A., Kardia, Sharon L. R., Kabagambe, Edmond, Broeckel, Ulrich, Chen, Guanjie, Zhou, Jie, Wassertheil-Smoller, Sylvia, Neuhouser, Marian L., Rampersaud, Evadnie, Psaty, Bruce, Kooperberg, Charles, Manson, JoAnn E., Kuller, Lewis H., Ochs-Balcom, Heather M., Johnson, Karen C., Sucheston, Lara, Ordovas, Jose M., Palmer, Julie R., Haiman, Christopher A., McKnight, Barbara, Howard, Barbara V., Becker, Diane M., Bielak, Lawrence F., Liu, Yongmei, Allison, Matthew A., Grant, Struan F. A., Burke, Gregory L., Patel, Sanjay R., Schreiner, Pamela J., Borecki, Ingrid B., Evans, Michele K., Taylor, Herman, Sale, Michele M., Howard, Virginia, Carlson, Christopher S., Rotimi, Charles N., Cushman, Mary, Harris, Tamara B., Reiner, Alexander P., Cupples, L. Adrienne, North, Kari E., Fox, Caroline S.
Publicado 2013

Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

por Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, Speliotes, Elizabeth K., Thorleifsson, Gudmar, Willer, Cristen J., Herrera, Blanca M., Jackson, Anne U., Lim, Noha, Scheet, Paul, Soranzo, Nicole, Amin, Najaf, Aulchenko, Yurii S., Chambers, John C., Drong, Alexander, Luan, Jian'an, Lyon, Helen N., Rivadeneira, Fernando, Sanna, Serena, Timpson, Nicholas J., Zillikens, M. Carola, Zhao, Jing Hua, Almgren, Peter, Bandinelli, Stefania, Bennett, Amanda J., Bergman, Richard N., Bonnycastle, Lori L., Bumpstead, Suzannah J., Chanock, Stephen J., Cherkas, Lynn, Chines, Peter, Coin, Lachlan, Cooper, Cyrus, Crawford, Gabriel, Doering, Angela, Dominiczak, Anna, Doney, Alex S. F., Ebrahim, Shah, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Ferrucci, Luigi, Fischer, Guido, Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Groves, Christopher J., Grundy, Scott, Guiducci, Candace, Hadley, David, Hamsten, Anders, Havulinna, Aki S., Hofman, Albert, Holle, Rolf, Holloway, John W., Illig, Thomas, Isomaa, Bo, Jacobs, Leonie C., Jameson, Karen, Jousilahti, Pekka, Karpe, Fredrik, Kuusisto, Johanna, Laitinen, Jaana, Lathrop, G. Mark, Lawlor, Debbie A., Mangino, Massimo, McArdle, Wendy L., Meitinger, Thomas, Morken, Mario A., Morris, Andrew P., Munroe, Patricia, Narisu, Narisu, Nordström, Anna, Nordström, Peter, Oostra, Ben A., Palmer, Colin N. A., Payne, Felicity, Peden, John F., Prokopenko, Inga, Renström, Frida, Ruokonen, Aimo, Salomaa, Veikko, Sandhu, Manjinder S., Scott, Laura J., Scuteri, Angelo, Silander, Kaisa, Song, Kijoung, Yuan, Xin, Stringham, Heather M., Swift, Amy J., Tuomi, Tiinamaija, Uda, Manuela, Vollenweider, Peter, Waeber, Gerard, Wallace, Chris, Walters, G. Bragi, Weedon, Michael N., Witteman, Jacqueline C. M., Zhang, Cuilin, Zhang, Weihua, Caulfield, Mark J., Collins, Francis S., Davey Smith, George, Day, Ian N. M., Franks, Paul W., Hattersley, Andrew T., Hu, Frank B., Jarvelin, Marjo-Riitta, Kong, Augustine, Kooner, Jaspal S., Laakso, Markku, Lakatta, Edward, Mooser, Vincent, Morris, Andrew D., Peltonen, Leena, Samani, Nilesh J., Spector, Timothy D., Strachan, David P., Tanaka, Toshiko, Tuomilehto, Jaakko, Uitterlinden, André G., van Duijn, Cornelia M., Wareham, Nicholas J., Watkins for the PROCARDIS consortia, Hugh, Waterworth, Dawn M., Boehnke, Michael, Deloukas, Panos, Groop, Leif, Hunter, David J., Thorsteinsdottir, Unnur, Schlessinger, David, Wichmann, H.-Erich, Frayling, Timothy M., Abecasis, Gonçalo R., Hirschhorn, Joel N., Loos, Ruth J. F., Stefansson, Kari, Mohlke, Karen L., Barroso, Inês, McCarthy for the GIANT consortium, Mark I.
Publicado 2009

Correction: Genome-Wide Association Scan Meta-Analysis Identifies Three Loci Influencing Adiposity and Fat Distribution

por Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir, Valgerdur, Qi, Lu, Speliotes, Elizabeth K., Thorleifsson, Gudmar, Willer, Cristen J., Herrera, Blanca M., Jackson, Anne U., Lim, Noha, Scheet, Paul, Soranzo, Nicole, Amin, Najaf, Aulchenko, Yurii S., Chambers, John C., Drong, Alexander, Luan, Jian'an, Lyon, Helen N., Rivadeneira, Fernando, Sanna, Serena, Timpson, Nicholas J., Zillikens, M. Carola, Zhao, Jing Hua, Almgren, Peter, Bandinelli, Stefania, Bennett, Amanda J., Bergman, Richard N., Bonnycastle, Lori L., Bumpstead, Suzannah J., Chanock, Stephen J., Cherkas, Lynn, Chines, Peter, Coin, Lachlan, Cooper, Cyrus, Crawford, Gabriel, Doering, Angela, Dominiczak, Anna, Doney, Alex S. F., Ebrahim, Shah, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Ferrucci, Luigi, Fischer, Guido, Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Groves, Christopher J., Grundy, Scott, Guiducci, Candace, Hadley, David, Hamsten, Anders, Havulinna, Aki S., Hofman, Albert, Holle, Rolf, Holloway, John W., Illig, Thomas, Isomaa, Bo, Jacobs, Leonie C., Jameson, Karen, Jousilahti, Pekka, Karpe, Fredrik, Kuusisto, Johanna, Laitinen, Jaana, Lathrop, G. Mark, Lawlor, Debbie A., Mangino, Massimo, McArdle, Wendy L., Meitinger, Thomas, Morken, Mario A., Morris, Andrew P., Munroe, Patricia, Narisu, Narisu, Nordström, Anna, Nordström, Peter, Oostra, Ben A., Palmer, Colin N. A., Payne, Felicity, Peden, John F., Prokopenko, Inga, Renström, Frida, Ruokonen, Aimo, Salomaa, Veikko, Sandhu, Manjinder S., Scott, Laura J., Scuteri, Angelo, Silander, Kaisa, Song, Kijoung, Yuan, Xin, Stringham, Heather M., Swift, Amy J., Tuomi, Tiinamaija, Uda, Manuela, Vollenweider, Peter, Waeber, Gerard, Wallace, Chris, Walters, G. Bragi, Weedon, Michael N., Witteman, Jacqueline C. M., Zhang, Cuilin, Zhang, Weihua, Caulfield, Mark J., Collins, Francis S., Davey Smith, George, Day, Ian N. M., Franks, Paul W., Hattersley, Andrew T., Hu, Frank B., Jarvelin, Marjo-Riitta, Kong, Augustine, Kooner, Jaspal S., Laakso, Markku, Lakatta, Edward, Mooser, Vincent, Morris, Andrew D., Peltonen, Leena, Samani, Nilesh J., Spector, Timothy D., Strachan, David P., Tanaka, Toshiko, Tuomilehto, Jaakko, Uitterlinden, André G., van Duijn, Cornelia M., Wareham, Nicholas J., Watkins for the PROCARDIS consortia, Hugh, Waterworth, Dawn M., Boehnke, Michael, Deloukas, Panos, Groop, Leif, Hunter, David J., Thorsteinsdottir, Unnur, Schlessinger, David, Wichmann, H.-Erich, Frayling, Timothy M., Abecasis, Gonçalo R., Hirschhorn, Joel N., Loos, Ruth J. F., Stefansson, Kari, Mohlke, Karen L., Barroso, Inês, McCarthy for the GIANT consortium, Mark I.
Publicado 2009