Long-term potentiation in bone – a role for glutamate in strain-induced cellular memory?

por Spencer, Gary J, Genever, Paul G
Publicado 2003

LSD1 inhibitors disrupt the GFI1 transcription repressor complex

por Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Publicado 2018

Enhancers of Polycomb EPC1 and EPC2 sustain the oncogenic potential of MLL leukemia stem cells

por Huang, Xu, Spencer, Gary J, Lynch, James T, Ciceri, Filippo, Somerville, Tim D D, Somervaille, Tim C P
Publicado 2013

A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival

por Jude, Julian G, Spencer, Gary J, Huang, Xu, Somerville, Tim D D, Jones, David R, Divecha, Nullin, Somervaille, Tim C P
Publicado 2014

Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia

por Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Publicado 2018

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

por Deb, Gauri, Wingelhofer, Bettina, Amaral, Fabio M. R., Maiques-Diaz, Alba, Chadwick, John A., Spencer, Gary J., Williams, Emma L., Leong, Hui-Sun, Maes, Tamara, Somervaille, Tim C. P.
Publicado 2019

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

por Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.
Publicado 2021

HMG20B stabilizes association of LSD1 with GFI1 on chromatin to confer transcription repression and leukemia cell differentiation block

por Maiques-Diaz, Alba, Nicosia, Luciano, Basma, Naseer J., Romero-Camarero, Isabel, Camera, Francesco, Spencer, Gary J., Amaral, Fabio M. R., Simeoni, Fabrizio, Wingelhofer, Bettina, Williamson, Andrew J. K., Pierce, Andrew, Whetton, Anthony D., Somervaille, Tim C. P.
Publicado 2022

Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia

por Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Publicado 2018

Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

por Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.
Publicado 2019