Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains

por Spencer, Jeffrey M., Zhang, Xiaoliu
Publicado 2017

Engineered dual selection for directed evolution of SpCas9 PAM specificity

por Goldberg, Gregory W., Spencer, Jeffrey M., Giganti, David O., Camellato, Brendan R., Agmon, Neta, Ichikawa, David M., Boeke, Jef D., Noyes, Marcus B.
Publicado 2021

The geometric influence on the Cys(2)His(2) zinc finger domain and functional plasticity

por Mueller, April L, Corbi-Verge, Carles, Giganti, David O, Ichikawa, David M, Spencer, Jeffrey M, MacRae, Mark, Garton, Michael, Kim, Philip M, Noyes, Marcus B
Publicado 2020

A universal deep-learning model for zinc finger design enables transcription factor reprogramming

por Ichikawa, David M., Abdin, Osama, Alerasool, Nader, Kogenaru, Manjunatha, Mueller, April L., Wen, Han, Giganti, David O., Goldberg, Gregory W., Adams, Samantha, Spencer, Jeffrey M., Razavi, Rozita, Nim, Satra, Zheng, Hong, Gionco, Courtney, Clark, Finnegan T., Strokach, Alexey, Hughes, Timothy R., Lionnet, Timothee, Taipale, Mikko, Kim, Philip M., Noyes, Marcus B.
Publicado 2023