Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile

por Schmidhammer, Helmut, Spetea, Mariana
Publicado 2012

Unveiling 7-Hydroxymitragynine as the Key Active Metabolite of Mitragynine and the Promise for Creating Novel Pain Relievers

por Spetea, Mariana, Schmidhammer, Helmut
Publicado 2019

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

por Spetea, Mariana, Schmidhammer, Helmut
Publicado 2020

Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones

por Spetea, Mariana, Schmidhammer, Helmut
Publicado 2021

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II

por Van Rijn, Richard M., Spetea, Mariana
Publicado 2022

5-Benzyl substituted 14-methoxymetopon, a high affinity μ opioid receptor agonist with potent antinociceptive activity in mice

por Spetea, Mariana, Bohotin, Catalina-Roxana, Schmidhammer, Helmut
Publicado 2008

Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists

por Noha, Stefan M., Schmidhammer, Helmut, Spetea, Mariana
Publicado 2017

Synthesis, opioid receptor binding profile and SAR studies of 14-alkoxy-substituted indolo- and benzofuromorphinans

por Staaf, Alexander, Spetea, Mariana, Mittendorfer, Harald, Schmidhammer, Helmut
Publicado 2008

Development of Diphenethylamines as Selective Kappa Opioid Receptor Ligands and Their Pharmacological Activities

por Schmidhammer, Helmut, Erli, Filippo, Guerrieri, Elena, Spetea, Mariana
Publicado 2020

Mechanistic Characterization of the Pharmacological Profile of HS-731, a Peripherally Acting Opioid Analgesic, at the µ-, δ-, κ-Opioid and Nociceptin Receptors

por Puls, Kristina, Schmidhammer, Helmut, Wolber, Gerhard, Spetea, Mariana
Publicado 2022

Bifunctional Peptidomimetic G Protein-Biased Mu-Opioid Receptor Agonist and Neuropeptide FF Receptor Antagonist KGFF09 Shows Efficacy in Visceral Pain without Rewarding Effects aft...

por Dumitrascuta, Maria, Martin, Charlotte, Ballet, Steven, Spetea, Mariana
Publicado 2022

Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain

por Schmidhammer, Helmut, Al-Khrasani, Mahmoud, Fürst, Susanna, Spetea, Mariana
Publicado 2023

A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids

por Asim, Muhammad Faheem, Wolber, Gerhard, Spetea, Mariana, Schmidhammer, Helmut
Publicado 2010

Comparison of physicochemical properties and biological activities of opioid morphinans interacting with mu opioid receptors

por Asim, Muhammad F, Bohotin, Catalina-Roxana, Spetea, Mariana, Schmidhammer, Helmut
Publicado 2008

μ Opioid receptor: novel antagonists and structural modeling

por Kaserer, Teresa, Lantero, Aquilino, Schmidhammer, Helmut, Spetea, Mariana, Schuster, Daniela
Publicado 2016

In vitro and in vivo Pharmacological Activities of 14-O-Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice

por Lattanzi, Roberta, Rief, Silvia, Schmidhammer, Helmut, Negri, Lucia, Spetea, Mariana
Publicado 2018

Mechanistic Understanding of Peptide Analogues, DALDA, [Dmt(1)]DALDA, and KGOP01, Binding to the Mu Opioid Receptor

por Dumitrascuta, Maria, Bermudez, Marcel, Ballet, Steven, Wolber, Gerhard, Spetea, Mariana
Publicado 2020

Influence of the 14-alkoxy group and the substitution in position 5 in N-methyl-14-alkoxymorphinan-6-ones on in vitro and in vivo pharmacological activities

por Haddou, Tanila Ben, Lattanzi, Roberta, Negri, Lucia, Schmidhammer, Helmut, Spetea, Mariana
Publicado 2012

In vitro and in vivo pharmacological profile of the 5-benzyl analogue of 14-methoxymetopon, a novel μ opioid analgesic with reduced propensity to alter motor function

por Spetea, Mariana, Bohotin, Catalina R., Asim, Muhammad F., Stübegger, Kurt, Schmidhammer, Helmut
Publicado 2010

Development of novel N-methyl and N-allyl-substituted oxazolomorphinans and their interaction with opioid receptors

por Sipos, Attila, Girán, Levente, Berényi, Sándor, Antus, Sándor, Schmidhammer, Helmut, Spetea, Mariana
Publicado 2011