Modulation of insulin secretion by RBFOX2-mediated alternative splicing

por Moss, Nicole D., Wells, Kristen L., Theis, Alexandra, Kim, Yong-Kyung, Spigelman, Aliya F., Liu, Xiong, MacDonald, Patrick E., Sussel, Lori
Publicado 2023

PI3 kinases p110α and PI3K-C2β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets

por Kolic, Jelena, Manning Fox, Jocelyn E., Chepurny, Oleg G., Spigelman, Aliya F., Ferdaoussi, Mourad, Schwede, Frank, Holz, George G., MacDonald, Patrick E.
Publicado 2016

Impacts of the COVID-19 pandemic on a human research islet program

por Dafoe, Tina J., Dos Santos, Theodore, Spigelman, Aliya F., Lyon, James, Smith, Nancy, Bautista, Austin, MacDonald, Patrick E., Manning Fox, Jocelyn E.
Publicado 2022

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

por Ferdaoussi, Mourad, Smith, Nancy, Lin, Haopeng, Bautista, Austin, Spigelman, Aliya F., Lyon, James, Dai, XiaoQing, Manning Fox, Jocelyn E., MacDonald, Patrick E.
Publicado 2020

Yield, cell composition, and function of islets isolated from different ages of neonatal pigs

por Arefanian, Hossein, Ramji, Qahir, Gupta, Nancy, Spigelman, Aliya F., Grynoch, Donald, MacDonald, Patrick E., Mueller, Thomas F., Gazda, Lawrence S., Rajotte, Ray V., Rayat, Gina R.
Publicado 2022

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking

por Cai, Erica P., Casimir, Marina, Schroer, Stephanie A., Luk, Cynthia T., Shi, Sally Yu, Choi, Diana, Dai, Xiao Qing, Hajmrle, Catherine, Spigelman, Aliya F., Zhu, Dan, Gaisano, Herbert Y., MacDonald, Patrick E., Woo, Minna
Publicado 2012

Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress

por Shrestha, Shristi, Erikson, Galina, Lyon, James, Spigelman, Aliya F., Bautista, Austin, Manning Fox, Jocelyn E., dos Santos, Cristiane, Shokhirev, Maxim, Cartailler, Jean-Philippe, Hetzer, Martin W., MacDonald, Patrick E., Arrojo e Drigo, Rafael
Publicado 2022

Loss of tetraspanin‐7 expression reduces pancreatic β‐cell exocytosis Ca(2+) sensitivity but has limited effect on systemic metabolism

por McLaughlin, Kerry, Acreman, Samuel, Nawaz, Sameena, Cutteridge, Joseph, Clark, Anne, Knudsen, Jakob G., Denwood, Geoffrey, Spigelman, Aliya F., Manning Fox, Jocelyn E., Singh, Sumeet Pal, MacDonald, Patrick E., Hastoy, Benoit, Zhang, Quan
Publicado 2022

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

por Lin, Haopeng, Smith, Nancy, Spigelman, Aliya F., Suzuki, Kunimasa, Ferdaoussi, Mourad, Alghamdi, Tamadher A., Lewandowski, Sophie L., Jin, Yaxing, Bautista, Austin, Wang, Ying Wayne, Manning Fox, Jocelyn E., Merrins, Matthew J., Buteau, Jean, MacDonald, Patrick E.
Publicado 2021

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

por Alghamdi, Tamadher A., Krentz, Nicole A.J., Smith, Nancy, Spigelman, Aliya F., Rajesh, Varsha, Jha, Alokkumar, Ferdaoussi, Mourad, Suzuki, Kunimasa, Yang, Jing, Manning Fox, Jocelyn E., Sun, Han, Sun, Zijie, Gloyn, Anna L., MacDonald, Patrick E.
Publicado 2022

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

por Rottner, Antje K., Ye, Yingying, Navarro-Guerrero, Elena, Rajesh, Varsha, Pollner, Alina, Bevacqua, Romina J., Yang, Jing, Spigelman, Aliya F., Baronio, Roberta, Bautista, Austin, Thomsen, Soren K., Lyon, James, Nawaz, Sameena, Smith, Nancy, Wesolowska-Andersen, Agata, Fox, Jocelyn E. Manning, Sun, Han, Kim, Seung K., Ebner, Daniel, MacDonald, Patrick E., Gloyn, Anna L.
Publicado 2022

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

por Kim, Angela, Knudsen, Jakob G, Madara, Joseph C, Benrick, Anna, Hill, Thomas G, Abdul Kadir, Lina, Kellard, Joely A, Mellander, Lisa, Miranda, Caroline, Lin, Haopeng, James, Timothy, Suba, Kinga, Spigelman, Aliya F, Wu, Yanling, MacDonald, Patrick E, Wernstedt Asterholm, Ingrid, Magnussen, Tore, Christensen, Mikkel, Vilsbøll, Tina, Salem, Victoria, Knop, Filip K, Rorsman, Patrik, Lowell, Bradford B, Briant, Linford JB
Publicado 2021

Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

por Mattis, Katia K., Krentz, Nicole A. J., Metzendorf, Christoph, Abaitua, Fernando, Spigelman, Aliya F., Sun, Han, Ikle, Jennifer M., Thaman, Swaraj, Rottner, Antje K., Bautista, Austin, Mazzaferro, Eugenia, Perez-Alcantara, Marta, Manning Fox, Jocelyn E., Torres, Jason M., Wesolowska-Andersen, Agata, Yu, Grace Z., Mahajan, Anubha, Larsson, Anders, MacDonald, Patrick E., Davies, Benjamin, den Hoed, Marcel, Gloyn, Anna L.
Publicado 2023