Secukinumab, a novel anti–IL-17A antibody, shows low immunogenicity potential in human in vitro assays comparable to other marketed biotherapeutics with low clinical immunogenicity...

por Karle, Anette, Spindeldreher, Sebastian, Kolbinger, Frank
Publicado 2016

Massive immune response against IVIg interferes with response against other antigens in mice: A new mode of action?

por Sordé, Laetitia, Spindeldreher, Sebastian, Palmer, Ed, Karle, Anette
Publicado 2017

Tregitopes and impaired antigen presentation: Drivers of the immunomodulatory effects of IVIg?

por Sordé, Laetitia, Spindeldreher, Sebastian, Palmer, Ed, Karle, Anette
Publicado 2017

Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab

por Spindeldreher, Sebastian, Maillère, Bernard, Correia, Evelyne, Tenon, Maxime, Karle, Anette, Jarvis, Philip, Kolbinger, Frank
Publicado 2018

Author Correction: Secukinumab Demonstrates Significantly Lower Immunogenicity Potential Compared to Ixekizumab

por Spindeldreher, Sebastian, Maillère, Bernard, Correia, Evelyne, Tenon, Maxime, Karle, Anette, Jarvis, Philip, Kolbinger, Frank
Publicado 2018

T cell epitope mapping of secukinumab and ixekizumab in healthy donors

por Spindeldreher, Sebastian, Karle, Anette, Correia, Evelyne, Tenon, Maxime, Gottlieb, Sascha, Huber, Thomas, Maillere, Bernard, Kolbinger, Frank
Publicado 2020

Characterization of CD4 T Cell Epitopes of Infliximab and Rituximab Identified from Healthy Donors

por Hamze, Moustafa, Meunier, Sylvain, Karle, Anette, Gdoura, Abdelaziz, Goudet, Amélie, Szely, Natacha, Pallardy, Marc, Carbonnel, Franck, Spindeldreher, Sebastian, Mariette, Xavier, Miceli-Richard, Corinne, Maillère, Bernard
Publicado 2017

A comparison of the ability of the human IgG1 allotypes G1m3 and G1m1,17 to stimulate T-cell responses from allotype matched and mismatched donors

por Webster, Carl I., Bryson, Christine J., Cloake, Edward A., Jones, Tim D., Austin, Mark J., Karle, Anette C., Spindeldreher, Sebastian, Lowe, David C., Baker, Matthew P.
Publicado 2016

Aggregation of Human Recombinant Monoclonal Antibodies Influences the Capacity of Dendritic Cells to Stimulate Adaptive T-Cell Responses In Vitro

por Rombach-Riegraf, Verena, Karle, Anette C., Wolf, Babette, Sordé, Laetitia, Koepke, Stephan, Gottlieb, Sascha, Krieg, Jennifer, Djidja, Marie-Claude, Baban, Aida, Spindeldreher, Sebastian, Koulov, Atanas V., Kiessling, Andrea
Publicado 2014

Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays

por Ducret, Axel, Ackaert, Chloé, Bessa, Juliana, Bunce, Campbell, Hickling, Timothy, Jawa, Vibha, Kroenke, Mark A., Lamberth, Kasper, Manin, Anaïs, Penny, Hweixian L., Smith, Noel, Terszowski, Grzegorz, Tourdot, Sophie, Spindeldreher, Sebastian
Publicado 2021

Low Percentage of Signal Regulatory Protein α/β(+) Memory B Cells in Blood Predicts Development of Anti-drug Antibodies (ADA) in Adalimumab-Treated Rheumatoid Arthritis Patients

por Magill, Laura, Adriani, Marsilio, Berthou, Véronique, Chen, Keguan, Gleizes, Aude, Hacein-Bey-Abina, Salima, Hincelin-Mery, Agnes, Mariette, Xavier, Pallardy, Marc, Spindeldreher, Sebastian, Szely, Natacha, Isenberg, David A., Manson, Jessica J., Jury, Elizabeth C., Mauri, Claudia
Publicado 2018

10(th) European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals

por Tourdot, S., Abdolzade-Bavil, A., Bessa, J., Broët, P., Fogdell-Hahn, A., Giorgi, M., Jawa, V., Kuranda, K., Legrand, N., Pattijn, S., Pedras-Vasconcelos, J. A., Rudy, A., Salmikangas, P., Scott, D. W., Snoeck, V., Smith, N., Spindeldreher, S., Kramer, D.
Publicado 2020

Treatment- and population-specific genetic risk factors for anti-drug antibodies against interferon-beta: a GWAS

por Andlauer, Till F. M., Link, Jenny, Martin, Dorothea, Ryner, Malin, Hermanrud, Christina, Grummel, Verena, Auer, Michael, Hegen, Harald, Aly, Lilian, Gasperi, Christiane, Knier, Benjamin, Müller-Myhsok, Bertram, Jensen, Poul Erik Hyldgaard, Sellebjerg, Finn, Kockum, Ingrid, Olsson, Tomas, Pallardy, Marc, Spindeldreher, Sebastian, Deisenhammer, Florian, Fogdell-Hahn, Anna, Hemmer, Bernhard
Publicado 2020

Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative...

por Rup, B, Pallardy, M, Sikkema, D, Albert, T, Allez, M, Broet, P, Carini, C, Creeke, P, Davidson, J, De Vries, N, Finco, D, Fogdell-Hahn, A, Havrdova, E, Hincelin-Mery, A, C Holland, M, H Jensen, P E, Jury, E C, Kirby, H, Kramer, D, Lacroix-Desmazes, S, Legrand, J, Maggi, E, Maillère, B, Mariette, X, Mauri, C, Mikol, V, Mulleman, D, Oldenburg, J, Paintaud, G, R Pedersen, C, Ruperto, N, Seitz, R, Spindeldreher, S, Deisenhammer, F
Publicado 2015

Clinicogenomic factors of biotherapy immunogenicity in autoimmune disease: A prospective multicohort study of the ABIRISK consortium

por Hässler, Signe, Bachelet, Delphine, Duhaze, Julianne, Szely, Natacha, Gleizes, Aude, Hacein-Bey Abina, Salima, Aktas, Orhan, Auer, Michael, Avouac, Jerôme, Birchler, Mary, Bouhnik, Yoram, Brocq, Olivier, Buck-Martin, Dorothea, Cadiot, Guillaume, Carbonnel, Franck, Chowers, Yehuda, Comabella, Manuel, Derfuss, Tobias, De Vries, Niek, Donnellan, Naoimh, Doukani, Abiba, Guger, Michael, Hartung, Hans-Peter, Kubala Havrdova, Eva, Hemmer, Bernhard, Huizinga, Tom, Ingenhoven, Kathleen, Hyldgaard-Jensen, Poul Erik, Jury, Elizabeth C., Khalil, Michael, Kieseier, Bernd, Laurén, Anna, Lindberg, Raija, Loercher, Amy, Maggi, Enrico, Manson, Jessica, Mauri, Claudia, Mohand Oumoussa, Badreddine, Montalban, Xavier, Nachury, Maria, Nytrova, Petra, Richez, Christophe, Ryner, Malin, Sellebjerg, Finn, Sievers, Claudia, Sikkema, Dan, Soubrier, Martin, Tourdot, Sophie, Trang, Caroline, Vultaggio, Alessandra, Warnke, Clemens, Spindeldreher, Sebastian, Dönnes, Pierre, Hickling, Timothy P., Hincelin Mery, Agnès, Allez, Matthieu, Deisenhammer, Florian, Fogdell-Hahn, Anna, Mariette, Xavier, Pallardy, Marc, Broët, Philippe
Publicado 2020