A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development

por Spiros, Athan, Geerts, Hugo
Publicado 2012

F189. PERSONALIZED MEDICINE: ESTIMATING THE IMPACT OF GENOTYPES ON ANTIPSYCHOTIC EFFICACY USING A QUANTITATIVE SYSTEMS PHARMACOLOGY APPROACH

por Geerts, Hugo, Spiros, Athan
Publicado 2018

Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach

por Geerts, Hugo, Spiros, Athan
Publicado 2020

Toward Predicting Impact of Common Genetic Variants on Schizophrenia Clinical Responses With Antipsychotics: A Quantitative System Pharmacology Study

por Spiros, Athan, Geerts, Hugo
Publicado 2021

Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate str...

por Spiros, Athan, Carr, Robert, Geerts, Hugo
Publicado 2010

A computer-based quantitative systems pharmacology model of negative symptoms in schizophrenia: exploring glycine modulation of excitation-inhibition balance

por Spiros, Athan, Roberts, Patrick, Geerts, Hugo
Publicado 2014

Assessing the synergy between cholinomimetics and memantine as augmentation therapy in cognitive impairment in schizophrenia. A virtual human patient trial using quantitative syste...

por Geerts, Hugo, Roberts, Patrick, Spiros, Athan
Publicado 2015

A Humanized Clinically Calibrated Quantitative Systems Pharmacology Model for Hypokinetic Motor Symptoms in Parkinson’s Disease

por Roberts, Patrick, Spiros, Athan, Geerts, Hugo
Publicado 2016

Impact of amyloid-beta changes on cognitive outcomes in Alzheimer’s disease: analysis of clinical trials using a quantitative systems pharmacology model

por Geerts, Hugo, Spiros, Athan, Roberts, Patrick
Publicado 2018

A biophysically realistic computer model of Alzheimer pathology to guide the development of symptomatic drugs

por Roberts, Patrick D, Spiros, Athan, Geerts, Hugo
Publicado 2012

Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

por Roberts, Patrick D, Spiros, Athan, Geerts, Hugo
Publicado 2012

A strategy for developing new treatment paradigms for neuropsychiatric and neurocognitive symptoms in Alzheimer’s disease

por Geerts, Hugo, Roberts, Patrick, Spiros, Athan, Carr, Robert
Publicado 2013

Blinded Prospective Evaluation of Computer-Based Mechanistic Schizophrenia Disease Model for Predicting Drug Response

por Geerts, Hugo, Spiros, Athan, Roberts, Patrick, Twyman, Roy, Alphs, Larry, Grace, Anthony A.
Publicado 2012

S221. QUANTITATIVE SYSTEMS PHARMACOLOGY AS AN ALTERNATIVE TO CHLORPROMAZINE EQUIVALENTS: PREDICTIVE VALIDATION FROM A CRIS DATABASE EXPERIMENT

por Geerts, Hugo, Spiros, Athan, Kadra, Giouliana, Stewart, Robert, Hayes, Richard, Shetty, Hitesh, Iqbal, Ehtesham
Publicado 2018

Predicting parkinsonism side-effects of antipsychotic polypharmacy prescribed in secondary mental healthcare

por Kadra, Giouliana, Spiros, Athan, Shetty, Hitesh, Iqbal, Ehtesham, Hayes, Richard D, Stewart, Robert, Geerts, Hugo
Publicado 2018