How does the NPM1 mutant induce leukemia?

por Sportoletti, Paolo
Publicado 2011

Lessons, Challenges and Future Therapeutic Opportunities for PI3K Inhibition in CLL

por Guarente, Valerio, Sportoletti, Paolo
Publicado 2021

Venetoclax-Rituximab Treatment of Relapsed/Refractory CLL During the COVID-19 Pandemic: A Real-Life Experience in Selected Central-Southern Italian Regions

por Molica, Stefano, Sportoletti, Paolo, Di Renzo, Nicola, Musto, Pellegrino, Pane, Fabrizio, Di Raimondo, Francesco
Publicado 2021

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML)

por Venanzi, Alessandra, Rossi, Roberta, Martino, Giovanni, Annibali, Ombretta, Avvisati, Giuseppe, Mameli, Maria Grazia, Sportoletti, Paolo, Tiacci, Enrico, Falini, Brunangelo, Martelli, Maria Paola
Publicado 2021

Polatuzumab‐bendamustine‐rituximab as bridge to CD19‐directed CAR T cells in mantle cell lymphoma refractory to ibrutinib and venetoclax

por Perriello, Vincenzo Maria, Falini, Lorenza, Ruggeri, Loredana, Sorcini, Daniele, Ballanti, Stelvio, Flenghi, Leonardo, Baffa, Nicodemo, Covarelli, Piero, Sportoletti, Paolo, Pierini, Antonio, Falini, Brunangelo
Publicado 2023

Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL

por De Falco, Filomena, Sabatini, Rita, Del Papa, Beatrice, Falzetti, Franca, Di Ianni, Mauro, Sportoletti, Paolo, Baldoni, Stefano, Screpanti, Isabella, Marconi, Pierfrancesco, Rosati, Emanuela
Publicado 2015

NOTCH1 Aberrations in Chronic Lymphocytic Leukemia

por Rosati, Emanuela, Baldoni, Stefano, De Falco, Filomena, Del Papa, Beatrice, Dorillo, Erica, Rompietti, Chiara, Albi, Elisa, Falzetti, Franca, Di Ianni, Mauro, Sportoletti, Paolo
Publicado 2018

Case Report: Contrasting BCL2 Upregulation With Venetoclax in a Case of Refractory Lymphomatoid Papulosis and Progressive Chronic Lymphocytic Leukemia

por Guarente, Valerio, Martino, Giovanni, Dorillo, Erica, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Brogna, Mariangela, Cardinali, Valeria, Ascani, Stefano, Marra, Andrea, Sportoletti, Paolo
Publicado 2021

Cytogenetic/mutation profile of chronic lymphocytic leukemia/malignant melanoma collision tumors of the skin

por La Starza, Roberta, Pierini, Tiziana, Pastorino, Lorenza, Albi, Elisa, Matteucci, Caterina, Crescenzi, Barbara, Sportoletti, Paolo, Covarelli, Piero, Falzetti, Franca, Roti, Giovanni, Ascani, Stefano, Mecucci, Cristina
Publicado 2018

NK Cells in Chronic Lymphocytic Leukemia and Their Therapeutic Implications

por Sportoletti, Paolo, De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Guarente, Valerio, Marra, Andrea, Dorillo, Erica, Rompietti, Chiara, Adamo, Francesco Maria, Ruggeri, Loredana, Di Ianni, Mauro, Rosati, Emanuela
Publicado 2021

The absent/low expression of CD34 in NPM1-mutated AML is not related to cytoplasmic dislocation of NPM1 mutant protein

por Pianigiani, Giulia, Rocchio, Francesca, Peruzzi, Sara, Andresen, Vibeke, Bigerna, Barbara, Sorcini, Daniele, Capurro, Michela, Gjertsen, Bjørn Tore, Sportoletti, Paolo, Di Ianni, Mauro, Martelli, Maria Paola, Brunetti, Lorenzo, Falini, Brunangelo
Publicado 2022

IL-4-dependent Jagged1 expression/processing is associated with survival of chronic lymphocytic leukemia cells but not with Notch activation

por De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Sabatini, Rita, Falzetti, Franca, Di Ianni, Mauro, Martelli, Maria Paola, Mezzasoma, Federica, Pelullo, Maria, Marconi, Pierfrancesco, Sportoletti, Paolo, Screpanti, Isabella, Rosati, Emanuela
Publicado 2018

COVID-19 Pandemic Impact on Chronic Lymphocytic Leukemia (CLL) Patients' Preferences Towards Therapies: The Italian Experience (CHOICE Study)

por Molica, Stefano, Laurenti, Luca, Ghia, Paolo, Coscia, Marta, Cuneo, Antonio, Gaidano, Gianluca, Mauro, Francesca, Frustaci, Anna Maria, Vallisa, Daniele, Pane, Fabrizio, Gualberti, Giuliana, Iannella, Emilia, Finsinger, Paola, Caira, Morena, Sportoletti, Paolo
Publicado 2021

NOTCH and Graft-Versus-Host Disease

por Di Ianni, Mauro, Del Papa, Beatrice, Baldoni, Stefano, Di Tommaso, Ambra, Fabi, Bianca, Rosati, Emanuela, Natale, Annalisa, Santarone, Stella, Olioso, Paola, Papalinetti, Gabriele, Giancola, Raffaella, Accorsi, Patrizia, Di Bartolomeo, Paolo, Sportoletti, Paolo, Falzetti, Franca
Publicado 2018

GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

por Sportoletti, Paolo, Celani, Letizia, Varasano, Emanuela, Rossi, Roberta, Sorcini, Daniele, Rompietti, Chiara, Strozzini, Francesca, Del Papa, Beatrice, Guarente, Valerio, Spinozzi, Giulio, Cecchini, Debora, Bereshchenko, Oxana, Haferlach, Torsten, Martelli, Maria Paola, Falzetti, Franca, Falini, Brunangelo
Publicado 2019

GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL

por De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Esposito, Angela, Scialdone, Annarita, Baldoni, Stefano, Del Papa, Beatrice, Adamo, Francesco Maria, Silva Barcelos, Estevão Carlos, Dorillo, Erica, Stella, Arianna, Di Ianni, Mauro, Screpanti, Isabella, Sportoletti, Paolo, Rosati, Emanuela
Publicado 2022

P1038: TL-895, A FIRST-IN-CLASS, COVALENT BRUTON TYROSINE KINASE INHIBITOR (BTKI) FOR THE TREATMENT OF MYELOFIBROSIS (MF) PATIENTS (PTS) WITH SEVERE THROMBOCYTOPENIA (PLATELETS (PL...

por Loschi, Michael, Rejto, Laszlo, Chuah, Hun, Caramella, Marianna, Hernández Rivas, Jesus, Sportoletti, Paolo, Dubruille, Viviane, Bellesso, Marcelo, Gröpper, Stefanie, Crodel, Carl, Qamoos, Hope, Socotch, Ashley, Huang, Zhuying, Wall, Sarah, Mcgreivy, Jesse, Rothbaum, Wayne P., Verstovsek, Srdan, Palandri, Francesca
Publicado 2023

Bepridil exhibits anti‐leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia

por Baldoni, Stefano, Del Papa, Beatrice, Dorillo, Erica, Aureli, Patrizia, De Falco, Filomena, Rompietti, Chiara, Sorcini, Daniele, Varasano, Emanuela, Cecchini, Debora, Zei, Tiziana, Di Tommaso, Ambra, Rosati, Emanuela, Alexe, Gabriela, Roti, Giovanni, Stegmaier, Kimberly, Di Ianni, Mauro, Falzetti, Franca, Sportoletti, Paolo
Publicado 2018

Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML

por Pianigiani, Giulia, Gagliardi, Andrea, Mezzasoma, Federica, Rocchio, Francesca, Tini, Valentina, Bigerna, Barbara, Sportoletti, Paolo, Caruso, Simona, Marra, Andrea, Peruzzi, Sara, Petito, Eleonora, Spinozzi, Giulio, Shacham, Sharon, Landesman, Yosef, Quintarelli, Concetta, Gresele, Paolo, Locatelli, Franco, Martelli, Maria Paola, Falini, Brunangelo, Brunetti, Lorenzo
Publicado 2022

NOTCH1-mutated chronic lymphocytic leukemia displays high endoplasmic reticulum stress response with druggable potential

por Silva Barcelos, Estevão Carlos, Rompietti, Chiara, Adamo, Francesco Maria, Dorillo, Erica, De Falco, Filomena, Del Papa, Beatrice, Baldoni, Stefano, Nogarotto, Manuel, Esposito, Angela, Capoccia, Silvia, Geraci, Clelia, Sorcini, Daniele, Stella, Arianna, Arcaleni, Roberta, Tini, Valentina, Imbroisi Valle Errera, Flávia, Rosati, Emanuela, Sportoletti, Paolo
Publicado 2023