Therapeutic efficacy of combined blockade of CTLA-4 +/- PD-L1 +/- IDO is associated with re-activation of T cells directly within the tumor microenvironment

por Spranger, Stefani, Gajewski, Thomas
Publicado 2013

Rational combinations of immunotherapeutics that target discrete pathways

por Spranger, Stefani, Gajewski, Thomas
Publicado 2013

A new paradigm for tumor immune escape: β-catenin-driven immune exclusion

por Spranger, Stefani, Gajewski, Thomas F.
Publicado 2015

Tumor-intrinsic oncogene pathways mediating immune avoidance

por Spranger, Stefani, Gajewski, Thomas F.
Publicado 2015

Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling

por Nguyen, Kim Bich, Spranger, Stefani
Publicado 2019

Melanoma-intrinsic β-catenin signaling prevents T cell infiltration and anti-tumor immunity

por Spranger, Stefani, Bao, Riyue, Gajewski, Thomas
Publicado 2014

Impact of anatomic site on antigen-presenting cells in cancer

por Zagorulya, Maria, Duong, Ellen, Spranger, Stefani
Publicado 2020

NOD/scid IL-2Rg(null )mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo

por Spranger, Stefani, Frankenberger, Bernhard, Schendel, Dolores J
Publicado 2012

Immune surveillance is thwarted by tumor-cell intrinsic beta-catenin signaling

por Spranger, Stefani, Horton, Brendan, Gajewski, Thomas F
Publicado 2015

A team effort: natural killer cells on the first leg of the tumor immunity relay race

por Fessenden, Timothy B., Duong, Ellen, Spranger, Stefani
Publicado 2018

Agonistic 4-1bb antibodies in combination with inhibitory antibodies against CTLA-4, PD-L1 or LAG-3 ACT on CD8+ T cells in the tumor microenvironment and synergize to promote regre...

por Horton, Brendan, Spranger, Stefani, Williams, Jason, Gajewski, Thomas
Publicado 2014

Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment

por Horton, Brendan, Williams, Jason B, Spranger, Stefani, Gajewski, Thomas F
Publicado 2015

Characterization of oncogenic pathways linked with T cell exclusion in urothelial bladder cancer

por Sweis, Randy F, Spranger, Stefani, Luke, Jason J, Gajewski, Thomas F
Publicado 2015

The genetic landscape of the T cell non-inflamed tumor microenvironment in human solid tumors

por Luke, Jason J, Spranger, Stefani, Bao, Riyue, Andrade, Jorge, Gajewski, Thomas F
Publicado 2015

Three-day dendritic cells for vaccine development: Antigen uptake, processing and presentation

por Bürdek, Maja, Spranger, Stefani, Wilde, Susanne, Frankenberger, Bernhard, Schendel, Dolores J, Geiger, Christiane
Publicado 2010

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor mi...

por Spranger, Stefani, Koblish, Holly K, Horton, Brendan, Scherle, Peggy A, Newton, Robert, Gajewski, Thomas F
Publicado 2014

Density of immunogenic antigens does not explain presence or absence of the T cell-inflamed tumor microenvironment in metastatic melanoma

por Zha, Yuanyuan, Spranger, Stefani, Hernandez, Kyle M, Li, Yan, Bao, Riyue, Alexieff, Peter, Andrade, Jorge, Luke, Jason J, Gajewski, Thomas F
Publicado 2015

Secondary resistance to immunotherapy associated with β-catenin pathway activation or PTEN loss in metastatic melanoma

por Trujillo, Jonathan A., Luke, Jason J., Zha, Yuanyuan, Segal, Jeremy P., Ritterhouse, Lauren L., Spranger, Stefani, Matijevich, Karen, Gajewski, Thomas F.
Publicado 2019

Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma

por Bao, Riyue, Spranger, Stefani, Hernandez, Kyle, Zha, Yuanyuan, Pytel, Peter, Luke, Jason J, Gajewski, Thomas F, Volchenboum, Samuel L, Cohn, Susan L, Desai, Ami V
Publicado 2021

Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins

por Fessenden, Tim B, Stopfer, Lauren E, Chatterjee, Fiona, Zulueta, Julian, Mesfin, Josh, Cordero Dumit, Therese, Reijers, Irene, Hoefsmit, Esmee P, Blank, Christian, White, Forest, Spranger, Stefani
Publicado 2022