T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

por Pedroza-Gonzalez, Alexander, Kwekkeboom, Jaap, Sprengers, Dave
Publicado 2013

TIGIT, the Next Step Towards Successful Combination Immune Checkpoint Therapy in Cancer

por Ge, Zhouhong, Peppelenbosch, Maikel P., Sprengers, Dave, Kwekkeboom, Jaap
Publicado 2021

Camrelizumab—targeting a novel PD-1 epitope to treat hepatocellular carcinoma

por Rakké, Yannick Sebastiaan, Sprengers, Dave, Kwekkeboom, Jaap, IJzermans, Jan Nicolaas Maria
Publicado 2020

Factors associated with ethnical disparity in overall survival for patients with hepatocellular carcinoma

por Li, Juan, Hansen, Bettina E, Peppelenbosch, Maikel P., De Man, Robert. A., Pan, Qiuwei, Sprengers, Dave
Publicado 2017

Blocking Wnt Secretion Reduces Growth of Hepatocellular Carcinoma Cell Lines Mostly Independent of β-Catenin Signaling()

por Wang, Wenhui, Xu, Lei, Liu, Pengyu, Jairam, Kiran, Yin, Yuebang, Chen, Kan, Sprengers, Dave, Peppelenbosch, Maikel P., Pan, Qiuwei, Smits, Ron
Publicado 2016

Cancer Cell B7-H3 Expression Is More Prevalent in the Pancreato-Biliary Subtype of Ampullary Cancer Than in Pancreatic Cancer

por Geerdes, Emma E., Sideras, Kostandinos, Aziz, M. Hosein, van Eijck, Casper H., Bruno, Marco J., Sprengers, Dave, Boor, Patrick P. C., Kwekkeboom, Jaap
Publicado 2021

Detection of oncogenic mutations in paired circulating tumor DNA and circulating tumor cells in patients with hepatocellular carcinoma

por Ge, Zhouhong, Helmijr, Jean C.A., Jansen, Maurice P.H.M., Boor, Patrick P.C., Noordam, Lisanne, Peppelenbosch, Maikel, Kwekkeboom, Jaap, Kraan, Jaco, Sprengers, Dave
Publicado 2021

External Validation of the RETREAT Score for Prediction of Hepatocellular Carcinoma Recurrence after Liver Transplantation

por van Hooff, Maria C., Sonneveld, Milan J., Ijzermans, Jan N., Doukas, Michail, Sprengers, Dave, Metselaar, Herold J., den Hoed, Caroline M., de Man, Robert A.
Publicado 2022

Dichotomal functions of phosphorylated and unphosphorylated STAT1 in hepatocellular carcinoma

por Ma, Buyun, Chen, Kan, Liu, Pengyu, Li, Meng, Liu, Jiaye, Sideras, Kostandinos, Sprengers, Dave, Biermann, Katharina, Wang, Wenshi, IJzermans, Jan N. M., Cao, Wanlu, Kwekkeboom, Jaap, Peppelenbosch, Maikel P., Pan, Qiuwei
Publicado 2018

Combining Sorafenib and Immunosuppression in Liver Transplant Recipients with Hepatocellular Carcinoma

por Hussaarts, Koen G. A. M., van Doorn, Leni, Bins, Sander, Sprengers, Dave, de Bruijn, Peter, van Leeuwen, Roelof W. F., Koolen, Stijn L. W., van Gelder, Teun, Mathijssen, Ron H. J.
Publicado 2021

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

por Boor, Patrick P. C., Sideras, Kostandinos, Biermann, Katharina, Hosein Aziz, M., Levink, Iris J. M., Mancham, Shanta, Erler, Nicole S., Tang, Xudong, van Eijck, Casper H., Bruno, Marco J., Sprengers, Dave, Zang, Xingxing, Kwekkeboom, Jaap
Publicado 2020

Enrichment of the tumour immune microenvironment in patients with desmoplastic colorectal liver metastasis

por Höppener, Diederik J., Nierop, Pieter M. H., Hof, Joost, Sideras, Kostandinos, Zhou, Guoying, Visser, Lydia, Gouw, Annette S. H., de Jong, Koert P., Sprengers, Dave, Kwekkeboom, Jaap, Vermeulen, Peter B., Grünhagen, Dirk J., Verhoef, Cornelis
Publicado 2020

Prognostic value of intra‐tumoral CD8(+)/FoxP3(+) lymphocyte ratio in patients with resected colorectal cancer liver metastasis

por Sideras, Kostandinos, Galjart, Boris, Vasaturo, Angela, Pedroza‐Gonzalez, Alexander, Biermann, Katharina, Mancham, Shanta, Nigg, Alex L., Hansen, Bettina E., Stoop, Hans A., Zhou, Guoying, Verhoef, Cornelis, Sleijfer, Stefan, Sprengers, Dave, Kwekkeboom, Jaap, Bruno, Marco J.
Publicado 2018

Systemic T-cell and humoral responses against cancer testis antigens in hepatocellular carcinoma patients

por Noordam, Lisanne, de Beijer, Monique T.A., Mancham, Shanta, Vogler, Isabel, Boor, Patrick P.C., de Ruiter, Valeska, Luijten, Robbie, IJzermans, Jan N.M., Sahin, Ugur, Bruno, Marco J., Sprengers, Dave, Buschow, Sonja I., Kwekkeboom, Jaap
Publicado 2022

Expression of Cancer Testis Antigens in Tumor-Adjacent Normal Liver Is Associated with Post-Resection Recurrence of Hepatocellular Carcinoma

por Noordam, Lisanne, Ge, Zhouhong, Özturk, Hadiye, Doukas, Michail, Mancham, Shanta, Boor, Patrick P. C., Campos Carrascosa, Lucia, Zhou, Guoying, van den Bosch, Thierry P. P., Pan, Qiuwei, IJzermans, Jan N. M., Bruno, Marco J., Sprengers, Dave, Kwekkeboom, Jaap
Publicado 2021

Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

por Li, Meng, Wang, Ling, Wang, Yijin, Zhang, Shaoshi, Zhou, Guoying, Lieshout, Ruby, Ma, Buyun, Liu, Jiaye, Qu, Changbo, Verstegen, Monique M. A., Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Cao, Wanlu, Peppelenbosch, Maikel P., Pan, Qiuwei
Publicado 2020

Protocol for the STRONG trial: stereotactic body radiation therapy following chemotherapy for unresectable perihilar cholangiocarcinoma, a phase I feasibility study

por Koedijk, Merel S, Heijmen, Ben J M, Groot Koerkamp, Bas, Eskens, Ferry A L M, Sprengers, Dave, Poley, Jan-Werner, van Gent, Dik C, van der Laan, Luc J W, van der Holt, Bronno, Willemssen, François E J A, Méndez Romero, Alejandra
Publicado 2018

Activated CD4(+) T Cells and Highly Differentiated Alloreactive CD4(+) T Cells Distinguish Operationally Tolerant Liver Transplantation Recipients

por Duizendstra, Aafke A., de Knegt, Robert J., Mancham, Shanta, Klepper, Mariska, Roelen, Dave L., Brand‐Schaaf, Simone H., Boor, Patrick P., Doukas, Michail, de Man, Robert A., Sprengers, Dave, Peppelenbosch, Maikel P., Betjes, Michiel G. H., Kwekkeboom, Jaap, Litjens, Nicolle H. R.
Publicado 2021

Convergent Transcription of Interferon-stimulated Genes by TNF-α and IFN-α Augments Antiviral Activity against HCV and HEV

por Wang, Wenshi, Xu, Lei, Brandsma, Johannes H., Wang, Yijin, Hakim, Mohamad S., Zhou, Xinying, Yin, Yuebang, Fuhler, Gwenny M., van der Laan, Luc J. W., van der Woude, C. Janneke, Sprengers, Dave, Metselaar, Herold J., Smits, Ron, Poot, Raymond A., Peppelenbosch, Maikel P., Pan, Qiuwei
Publicado 2016

Blockade of LAG3 enhances responses of tumor-infiltrating T cells in mismatch repair-proficient liver metastases of colorectal cancer

por Zhou, Guoying, Noordam, Lisanne, Sprengers, Dave, Doukas, Michail, Boor, Patrick P. C., van Beek, Adriaan A., Erkens, Remco, Mancham, Shanta, Grünhagen, Dirk, Menon, Anand G., Lange, Johan F., Burger, Pim J. W. A., Brandt, Alexandra, Galjart, Boris, Verhoef, Cornelis, Kwekkeboom, Jaap, Bruno, Marco J.
Publicado 2018