Cis-inhibition suppresses basal Notch signaling during sensory organ precursor selection

por Troost, Tobias, Binshtok, Udi, Sprinzak, David, Klein, Thomas
Publicado 2023

Functional Comparison between Endogenous and Synthetic Notch Systems

por Khamaisi, Bassma, Luca, Vincent C., Blacklow, Stephen C., Sprinzak, David
Publicado 2022

Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning

por Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Garcia-Ojalvo, Jordi, Elowitz, Michael B.
Publicado 2011

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

por LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B
Publicado 2014

Correction: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

por LeBon, Lauren, Lee, Tom V, Sprinzak, David, Jafar-Nejad, Hamed, Elowitz, Michael B
Publicado 2014

A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

por Loza, Olga, Heemskerk, Idse, Gordon-Bar, Nadav, Amir-Zilberstein, Liat, Jung, Yunmin, Sprinzak, David
Publicado 2017

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness

por Taiber, Shahar, Cohen, Roie, Yizhar‐Barnea, Ofer, Sprinzak, David, Holt, Jeffrey R, Avraham, Karen B
Publicado 2020

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

por Medina, Elliot, Easa, Yathreb, Lester, Daniel K., Lau, Eric K., Sprinzak, David, Luca, Vincent C.
Publicado 2023

Dynamic Ligand Discrimination in the Notch Signaling Pathway

por Nandagopal, Nagarajan, Santat, Leah A., LeBon, Lauren, Sprinzak, David, Bronner, Marianne E., Elowitz, Michael B.
Publicado 2018

MPDZ promotes DLL4-induced Notch signaling during angiogenesis

por Tetzlaff, Fabian, Adam, M Gordian, Feldner, Anja, Moll, Iris, Menuchin, Amitai, Rodriguez-Vita, Juan, Sprinzak, David, Fischer, Andreas
Publicado 2018

Cis Interactions between Notch and Delta Generate Mutually Exclusive Signaling States

por Sprinzak, David, Lakhanpal, Amit, LeBon, Lauren, Santat, Leah A., Fontes, Michelle E., Anderson, Graham A., Garcia-Ojalvo, Jordi, Elowitz, Michael B.
Publicado 2010

Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer

por Liubomirski, Yulia, Lerrer, Shalom, Meshel, Tsipi, Morein, Dina, Rubinstein-Achiasaf, Linor, Sprinzak, David, Wiemann, Stefan, Körner, Cindy, Ehrlich, Marcelo, Ben-Baruch, Adit
Publicado 2019

Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear

por Cohen, Roie, Amir-Zilberstein, Liat, Hersch, Micha, Woland, Shiran, Loza, Olga, Taiber, Shahar, Matsuzaki, Fumio, Bergmann, Sven, Avraham, Karen B., Sprinzak, David
Publicado 2020

Therapeutic gene silencing of CKAP5 leads to lethality in genetically unstable cancer cells

por Chatterjee, Sushmita, Naidu, Gonna Somu, Hazan-Halevy, Inbal, Grobe, Hanna, Ezra, Assaf, Sharma, Preeti, Goldsmith, Meir, Ramishetti, Srinivas, Sprinzak, David, Zaidel-Bar, Ronen, Peer, Dan
Publicado 2023

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

por Kuang, Yi, Pyo, Anna, Eafergan, Natanel, Cain, Brittany, Gutzwiller, Lisa M., Axelrod, Ofri, Gagliani, Ellen K., Weirauch, Matthew T., Kopan, Raphael, Kovall, Rhett A., Sprinzak, David, Gebelein, Brian
Publicado 2021

A Nesprin-4/kinesin-1 cargo model for nuclear positioning in cochlear outer hair cells

por Taiber, Shahar, Gozlan, Oren, Cohen, Roie, Andrade, Leonardo R., Gregory, Ellen F., Starr, Daniel A., Moran, Yehu, Hipp, Rebecca, Kelley, Matthew W., Manor, Uri, Sprinzak, David, Avraham, Karen B.
Publicado 2022

Cell-cell contact area affects Notch signaling and Notch-dependent patterning

por Shaya, Oren, Binshtok, Udi, Hersch, Micha, Rivkin, Dmitri, Weinreb, Sheila, Amir-Zilberstein, Liat, Khamaisi, Bassma, Oppenheim, Olya, Desai, Ravi A., Goodyear, Richard J., Richardson, Guy P., Chen, Christopher S., Sprinzak, David
Publicado 2017

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestatio...

por Kobia, Francis M., Preusse, Kristina, Dai, Quanhui, Weaver, Nicholas, Hass, Matthew R., Chaturvedi, Praneet, Stein, Sarah J., Pear, Warren S., Yuan, Zhenyu, Kovall, Rhett A., Kuang, Yi, Eafergen, Natanel, Sprinzak, David, Gebelein, Brian, Brunskill, Eric W., Kopan, Raphael
Publicado 2020

Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain

por Dray, Nicolas, Mancini, Laure, Binshtok, Udi, Cheysson, Felix, Supatto, Willy, Mahou, Pierre, Bedu, Sébastien, Ortica, Sara, Than-Trong, Emmanuel, Krecsmarik, Monika, Herbert, Sébastien, Masson, Jean-Baptiste, Tinevez, Jean-Yves, Lang, Gabriel, Beaurepaire, Emmanuel, Sprinzak, David, Bally-Cuif, Laure
Publicado 2021

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

por Kuang, Yi, Golan, Ohad, Preusse, Kristina, Cain, Brittany, Christensen, Collin J, Salomone, Joseph, Campbell, Ian, Okwubido-Williams, FearGod V, Hass, Matthew R, Yuan, Zhenyu, Eafergan, Nathanel, Moberg, Kenneth H, Kovall, Rhett A, Kopan, Raphael, Sprinzak, David, Gebelein, Brian
Publicado 2020