Elevated Dkk1 Mediates Downregulation of the Canonical Wnt Pathway and Lysosomal Loss in an iPSC Model of Neuronopathic Gaucher Disease

por Srikanth, Manasa P., Feldman, Ricardo A.
Publicado 2020

Acid ceramidase involved in pathogenic cascade leading to accumulation of α-synuclein in iPSC model of GBA1-associated Parkinson’s disease

por Kumar, Manoj, Srikanth, Manasa P, Deleidi, Michela, Hallett, Penelope J, Isacson, Ole, Feldman, Ricardo A
Publicado 2023

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1

por Srikanth, Manasa P., Jones, Jace W., Kane, Maureen, Awad, Ola, Park, Tea Soon, Zambidis, Elias T., Feldman, Ricardo A.
Publicado 2021

mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells

por Brown, Robert A., Voit, Antanina, Srikanth, Manasa P., Thayer, Julia A., Kingsbury, Tami J., Jacobson, Marlene A., Lipinski, Marta M., Feldman, Ricardo A., Awad, Ola
Publicado 2019

Altered Differentiation Potential of Gaucher’s Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation

por Awad, Ola, Panicker, Leelamma M., Deranieh, Rania M., Srikanth, Manasa P., Brown, Robert A., Voit, Antanina, Peesay, Tejasvi, Park, Tea Soon, Zambidis, Elias T., Feldman, Ricardo A.
Publicado 2017

Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein

por Gould, Nicole R, Williams, Katrina M, Joca, Humberto C, Torre, Olivia M, Lyons, James S, Leser, Jenna M, Srikanth, Manasa P, Hughes, Marcus, Khairallah, Ramzi J, Feldman, Ricardo A, Ward, Christopher W, Stains, Joseph P
Publicado 2021