Does Soluble TREM2 Protect Against Alzheimer's Disease?

por Brown, Guy C., St George-Hyslop, Peter
Publicado 2022

Drug Repositioning for Alzheimer’s Disease Based on Systematic ‘omics’ Data Mining

por Zhang, Ming, Schmitt-Ulms, Gerold, Sato, Christine, Xi, Zhengrui, Zhang, Yalun, Zhou, Ye, St George-Hyslop, Peter, Rogaeva, Ekaterina
Publicado 2016

The physiological and pathological biophysics of phase separation and gelation of RNA binding proteins in amyotrophic lateral sclerosis and fronto-temporal lobar degeneration

por St George-Hyslop, Peter, Lin, Julie Qiaojin, Miyashita, Akinori, Phillips, Emma C., Qamar, Seema, Randle, Suzanne J., Wang, GuoZhen
Publicado 2018

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation

por Carrillo-Jimenez, Alejandro, Puigdellívol, Mar, Vilalta, Anna, Venero, Jose Luis, Brown, Guy Charles, StGeorge-Hyslop, Peter, Burguillos, Miguel Angel
Publicado 2018

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage

por Pardossi-Piquard, Raphaëlle, Böhm, Christopher, Chen, Fusheng, Kanemoto, Soshi, Checler, Frédéric, Schmitt-Ulms, Gerold, St. George-Hyslop, Peter, Fraser, Paul E.
Publicado 2009

Structural biology of presenilin 1 complexes

por Li, Yi, Bohm, Christopher, Dodd, Roger, Chen, Fusheng, Qamar, Seema, Schmitt-Ulms, Gerold, Fraser, Paul E, St George-Hyslop, Peter H
Publicado 2014

Genome-Wide Survey of Large Rare Copy Number Variants in Alzheimer’s Disease Among Caribbean Hispanics

por Ghani, Mahdi, Pinto, Dalila, Lee, Joseph H., Grinberg, Yakov, Sato, Christine, Moreno, Danielle, Scherer, Stephen W., Mayeux, Richard, St. George-Hyslop, Peter, Rogaeva, Ekaterina
Publicado 2012

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology

por Michel, Claire H., Kumar, Satish, Pinotsi, Dorothea, Tunnacliffe, Alan, St. George-Hyslop, Peter, Mandelkow, Eckhard, Mandelkow, Eva-Maria, Kaminski, Clemens F., Kaminski Schierle, Gabriele S.
Publicado 2014

Longitudinal evaluation of Tau‐P301L transgenic mice reveals no cognitive impairments at 17 months of age

por Kent, Brianne A., Heath, Christopher J., Kim, Chi Hun, Ahrens, Rosemary, Fraser, Paul E., St George‐Hyslop, Peter, Bussey, Timothy J., Saksida, Lisa M.
Publicado 2017

Prevention of Alzheimer's disease in high risk groups: statin therapy in subjects with PSEN1 mutations or heterozygosity for apolipoprotein E epsilon 4

por Pollen, Daniel A, Baker, Stephen, Hinerfeld, Douglas, Swearer, Joan, Evans, Barbara A, Evans, James E, Caselli, Richard, Rogaeva, Ekaterina, St George-Hyslop, Peter, Moonis, Majaz
Publicado 2010

Single-Molecule Imaging Reveals that Small Amyloid-β(1–42) Oligomers Interact with the Cellular Prion Protein (PrP(C))

por Ganzinger, Kristina A, Narayan, Priyanka, Qamar, Seema S, Weimann, Laura, Ranasinghe, Rohan T, Aguzzi, Adriano, Dobson, Christopher M, McColl, James, St George-Hyslop, Peter, Klenerman, David
Publicado 2014

Regulation of membrane fluidity by RNF145‐triggered degradation of the lipid hydrolase ADIPOR2

por Volkmar, Norbert, Gawden‐Bone, Christian M, Williamson, James C, Nixon‐Abell, Jonathon, West, James A, St George‐Hyslop, Peter H, Kaser, Arthur, Lehner, Paul J
Publicado 2022

SPATACSIN mutations cause autosomal recessive juvenile amyotrophic lateral sclerosis

por Orlacchio, Antonio, Babalini, Carla, Borreca, Antonella, Patrono, Clarice, Massa, Roberto, Basaran, Sarenur, Munhoz, Renato P., Rogaeva, Ekaterina A., St George-Hyslop, Peter H., Bernardi, Giorgio, Kawarai, Toshitaka
Publicado 2010

Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice

por Audrain, Mickael, Haure‐Mirande, Jean‐Vianney, Mleczko, Justyna, Wang, Minghui, Griffin, Jennifer K., St George‐Hyslop, Peter H., Fraser, Paul, Zhang, Bin, Gandy, Sam, Ehrlich, Michelle E.
Publicado 2020

Spatially non-uniform condensates emerge from dynamically arrested phase separation

por Erkamp, Nadia A., Sneideris, Tomas, Ausserwöger, Hannes, Qian, Daoyuan, Qamar, Seema, Nixon-Abell, Jonathon, St George-Hyslop, Peter, Schmit, Jeremy D., Weitz, David A., Knowles, Tuomas P. J.
Publicado 2023

Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

por Narayan, Priyanka, Ganzinger, Kristina A., McColl, James, Weimann, Laura, Meehan, Sarah, Qamar, Seema, Carver, John A., Wilson, Mark R., St. George-Hyslop, Peter, Dobson, Christopher M., Klenerman, David
Publicado 2013

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies

por Pickhardt, Marcus, Neumann, Thomas, Schwizer, Daniel, Callaway, Kari, Vendruscolo, Michele, Schenk, Dale, St. George-Hyslop, Peter, Mandelkow, Eva M., Dobson, Christopher M., McConlogue, Lisa, Mandelkow, Eckhard, Tóth, Gergely
Publicado 2015

δ-Catenin Is Genetically and Biologically Associated with Cortical Cataract and Future Alzheimer-Related Structural and Functional Brain Changes

por Jun, Gyungah, Moncaster, Juliet A., Koutras, Carolina, Seshadri, Sudha, Buros, Jacqueline, McKee, Ann C., Levesque, Georges, Wolf, Philip A., St. George-Hyslop, Peter, Goldstein, Lee E., Farrer, Lindsay A.
Publicado 2012

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

por Narayan, Priyanka, Holmström, Kira M., Kim, Dong-Hyun, Whitcomb, Daniel J., Wilson, Mark R., St. George-Hyslop, Peter, Wood, Nicholas W., Dobson, Christopher M., Cho, Kwangwook, Abramov, Andrey Y., Klenerman, David
Publicado 2014

APOE ε4, white matter hyperintensities, and cognition in Alzheimer and Lewy body dementia

por Mirza, Saira Saeed, Saeed, Usman, Knight, Jo, Ramirez, Joel, Stuss, Donald T., Keith, Julia, Nestor, Sean M., Yu, Di, Swardfager, Walter, Rogaeva, Ekaterina, St. George Hyslop, Peter, Black, Sandra E., Masellis, Mario
Publicado 2019