Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

por Lin, Steven, Staahl, Brett T, Alla, Ravi K, Doudna, Jennifer A
Publicado 2014

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

por Oakes, Benjamin L, Nadler, Dana C., Flamholz, Avi, Fellmann, Christof, Staahl, Brett T., Doudna, Jennifer A., Savage, David F.
Publicado 2016

A thermostable Cas9 with increased lifetime in human plasma

por Harrington, Lucas B., Paez-Espino, David, Staahl, Brett T., Chen, Janice S., Ma, Enbo, Kyrpides, Nikos C., Doudna, Jennifer A.
Publicado 2017

Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery

por Gaj, Thomas, Staahl, Brett T., Rodrigues, Gonçalo M. C., Limsirichai, Prajit, Ekman, Freja K., Doudna, Jennifer A., Schaffer, David V.
Publicado 2017

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

por Shams, Arik, Higgins, Sean A., Fellmann, Christof, Laughlin, Thomas G., Oakes, Benjamin L., Lew, Rachel, Kim, Shin, Lukarska, Maria, Arnold, Madeline, Staahl, Brett T., Doudna, Jennifer A., Savage, David F.
Publicado 2021

Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine–Cysteine Bond Formation

por Lobba, Marco J., Fellmann, Christof, Marmelstein, Alan M., Maza, Johnathan C., Kissman, Elijah N., Robinson, Stephanie A., Staahl, Brett T., Urnes, Cole, Lew, Rachel J., Mogilevsky, Casey S., Doudna, Jennifer A., Francis, Matthew B.
Publicado 2020

CRISPR-CasX is an RNA-dominated enzyme active for human genome editing

por Liu, Jun-Jie, Orlova, Natalia, Oakes, Benjamin L., Ma, Enbo, Spinner, Hannah B., Baney, Katherine L.M., Chuck, Jonathan, Tan, Dan, Knott, Gavin J., Harrington, Lucas B., Al-Shayeb, Basem, Wagner, Alexander, Brötzmann, Julian, Staahl, Brett T., Talyor, Kian L., Desmarais, John, Nogales, Eva, Doudna, Jennifer A.
Publicado 2019

Exome sequencing to identify de novo mutations in sporadic ALS trios

por Chesi, Alessandra, Staahl, Brett T., Jovicic, Ana, Couthouis, Julien, Fasolino, Maria, Raphael, Alya R., Yamazaki, Tomohiro, Elias, Laura, Polak, Meraida, Kelly, Crystal, Williams, Kelly L., Fifita, Jennifer A., Maragakis, Nicholas J., Nicholson, Garth A., King, Oliver D., Reed, Robin, Crabtree, Gerald R., Blair, Ian P., Glass, Jonathan D., Gitler, Aaron D.
Publicado 2013

Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism

por Wenderski, Wendy, Wang, Lu, Krokhotin, Andrey, Walsh, Jessica J., Li, Hongjie, Shoji, Hirotaka, Ghosh, Shereen, George, Renee D., Miller, Erik L., Elias, Laura, Gillespie, Mark A., Son, Esther Y., Staahl, Brett T., Baek, Seung Tae, Stanley, Valentina, Moncada, Cynthia, Shipony, Zohar, Linker, Sara B., Marchetto, Maria C. N., Gage, Fred H., Chen, Dillon, Sultan, Tipu, Zaki, Maha S., Ranish, Jeffrey A., Miyakawa, Tsuyoshi, Luo, Liqun, Malenka, Robert C., Crabtree, Gerald R., Gleeson, Joseph G.
Publicado 2020