Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

por Briston, Thomas, Roberts, Malcolm, Lewis, Sian, Powney, Ben, M. Staddon, James, Szabadkai, Gyorgy, Duchen, Michael R.
Publicado 2017

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

por Cosker, Katharina, Mallach, Anna, Limaye, Janhavi, Piers, Thomas M., Staddon, James, Neame, Stephen J., Hardy, John, Pocock, Jennifer M.
Publicado 2021

Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

por Tsefou, Eliona, Walker, Alison S., Clark, Emily H., Hicks, Amy R., Luft, Christin, Takeda, Kunitoshi, Watanabe, Toru, Ramazio, Bianca, Staddon, James M., Briston, Thomas, Ketteler, Robin
Publicado 2021

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

por Briston, Thomas, Lewis, Sian, Koglin, Mumta, Mistry, Kavita, Shen, Yongchun, Hartopp, Naomi, Katsumata, Ryosuke, Fukumoto, Hironori, Duchen, Michael R., Szabadkai, Gyorgy, Staddon, James M., Roberts, Malcolm, Powney, Ben
Publicado 2016

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

por Papkovskaia, Tatiana D., Chau, Kai-Yin, Inesta-Vaquera, Francisco, Papkovsky, Dmitri B., Healy, Daniel G., Nishio, Koji, Staddon, James, Duchen, Michael R., Hardy, John, Schapira, Anthony H.V., Cooper, J. Mark
Publicado 2012

Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer’s disease

por Roberts, Malcolm, Sevastou, Ioanna, Imaizumi, Yoichi, Mistry, Kavita, Talma, Sonia, Dey, Madhurima, Gartlon, Jane, Ochiai, Hiroshi, Zhou, Zhi, Akasofu, Shigeru, Tokuhara, Naoki, Ogo, Makoto, Aoyama, Muneo, Aoyagi, Hirofumi, Strand, Kate, Sajedi, Ezat, Agarwala, Kishan Lal, Spidel, Jared, Albone, Earl, Horie, Kanta, Staddon, James M., de Silva, Rohan
Publicado 2020