Biologics as novel therapeutics for the treatment of allergy: Challenges and opportunities

por Atanasio, Amanda, Orengo, Jamie M., Sleeman, Matthew A., Stahl, Neil
Publicado 2022

Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes

por Ramanathan, Aarti, Gusarova, Viktoria, Stahl, Neil, Gurnett-Bander, Anne, Kyratsous, Christos A.
Publicado 2016

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

por Papadopoulos, Nicholas, Martin, Joel, Ruan, Qin, Rafique, Ashique, Rosconi, Michael P., Shi, Ergang, Pyles, Erica A., Yancopoulos, George D., Stahl, Neil, Wiegand, Stanley J.
Publicado 2012

The Efficacy, Tolerability, and Joint Safety of Fasinumab in Osteoarthritis Pain: A Phase IIb/III Double‐Blind, Placebo‐Controlled, Randomized Clinical Trial

por Dakin, Paula, DiMartino, Stephen J., Gao, Haitao, Maloney, Jennifer, Kivitz, Alan J., Schnitzer, Thomas J., Stahl, Neil, Yancopoulos, George D., Geba, Gregory P.
Publicado 2019

Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)

por Sieper, Joachim, Braun, Jürgen, Kay, Jonathan, Badalamenti, Salvatore, Radin, Allen R, Jiao, Lixia, Fiore, Stefano, Momtahen, Tanya, Yancopoulos, George D, Stahl, Neil, Inman, Robert D
Publicado 2015

Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the r...

por Huizinga, Tom W J, Fleischmann, Roy M, Jasson, Martine, Radin, Allen R, van Adelsberg, Janet, Fiore, Stefano, Huang, Xiaohong, Yancopoulos, George D, Stahl, Neil, Genovese, Mark C
Publicado 2014

Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets

por de Wit, Emmie, Feldmann, Friederike, Okumura, Atsushi, Horne, Eva, Haddock, Elaine, Saturday, Greg, Scott, Dana, Erlandson, Karl J., Stahl, Neil, Lipsich, Leah, Kyratsous, Christos A., Feldmann, Heinz
Publicado 2018

Efficacy and safety of fasinumab in patients with chronic low back pain: a phase II/III randomised clinical trial

por Dakin, Paula, Kivitz, Alan J, Gimbel, Joseph S, Skrepnik, Nebojsa, DiMartino, Stephen J, Emeremni, Chetachi A, Gao, Haitao, Stahl, Neil, Weinreich, David M, Yancopoulos, George D, Geba, Gregory P
Publicado 2021

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

por Baum, Alina, Fulton, Benjamin O., Wloga, Elzbieta, Copin, Richard, Pascal, Kristen E., Russo, Vincenzo, Giordano, Stephanie, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Atwal, Gurinder S., Murphy, Andrew J., Stahl, Neil, Yancopoulos, George D., Kyratsous, Christos A.
Publicado 2020

Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus

por Sivapalasingam, Sumathi, Saviolakis, George A, Kulcsar, Kirsten, Nakamura, Aya, Conrad, Thomas, Hassanein, Mohamed, Sumner, Giane, Elango, Chinnasamy, Kamal, Mohamed A, Eng, Simon, Kyratsous, Christos A, Musser, Bret J, Frieman, Matthew, Kantrowitz, Joel, Weinreich, David M, Yancopoulos, George, Stahl, Neil, Lipsich, Leah
Publicado 2021

A novel, native-format bispecific antibody triggering T-cell killing of B-cells is robustly active in mouse tumor models and cynomolgus monkeys

por Smith, Eric J., Olson, Kara, Haber, Lauric J., Varghese, Bindu, Duramad, Paurene, Tustian, Andrew D., Oyejide, Adelekan, Kirshner, Jessica R., Canova, Lauren, Menon, Jayanthi, Principio, Jennifer, MacDonald, Douglas, Kantrowitz, Joel, Papadopoulos, Nicholas, Stahl, Neil, Yancopoulos, George D., Thurston, Gavin, Davis, Samuel
Publicado 2015

Passive Prophylactic Administration with a Single Dose of Anti–Fel d 1 Monoclonal Antibodies REGN1908–1909 in Cat Allergen–induced Allergic Rhinitis: A Randomized, Double-Blind, Pl...

por Shamji, Mohamed H., Singh, Iesha, Layhadi, Janice A., Ito, Constance, Karamani, Angeliki, Kouser, Lubna, Sharif, Hanisah, Tang, Jiaqian, Handijiev, Sava, Parkin, Rebecca V., Durham, Stephen R., Kostic, Ana, Orengo, Jamie M., DeVeaux, Michelle, Kamal, Mohamed, Stahl, Neil, Yancopoulos, George D., Wang, Claire Q., Radin, Allen R.
Publicado 2021

Dual blockade of IL‐4 and IL‐13 with dupilumab, an IL‐4Rα antibody, is required to broadly inhibit type 2 inflammation

por Le Floc’h, Audrey, Allinne, Jeanne, Nagashima, Kirsten, Scott, George, Birchard, Dylan, Asrat, Seblewongel, Bai, Yu, Lim, Wei Keat, Martin, Joel, Huang, Tammy, Potocky, Terra B., Kim, Jee H., Rafique, Ashique, Papadopoulos, Nicholas J., Stahl, Neil, Yancopoulos, George D., Murphy, Andrew J., Sleeman, Matthew A., Orengo, Jamie M.
Publicado 2020

Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes

por MacDonald, Douglas A., Martin, Joel, Muthusamy, Kathir K., Luo, Jiann-Kae, Pyles, Erica, Rafique, Ashique, Huang, Tammy, Potocky, Terra, Liu, Yang, Cao, Jingtai, Bono, Françoise, Delesque, Nathalie, Savi, Pierre, Francis, John, Amirkhosravi, Ali, Meyer, Todd, Romano, Carmelo, Glinka, Meredith, Yancopoulos, George D., Stahl, Neil, Wiegand, Stanley J., Papadopoulos, Nicholas
Publicado 2016

Efficacy and Safety of Multiple Dupilumab Dose Regimens After Initial Successful Treatment in Patients With Atopic Dermatitis: A Randomized Clinical Trial

por Worm, Margitta, Simpson, Eric L., Thaçi, Diamant, Bissonnette, Robert, Lacour, Jean-Philippe, Beissert, Stefan, Kawashima, Makoto, Ferrándiz, Carlos, Smith, Catherine H., Beck, Lisa A., Chan, Kuo-Chen, Chen, Zhen, Akinlade, Bolanle, Hultsch, Thomas, Staudinger, Heribert, Gadkari, Abhijit, Eckert, Laurent, Davis, John D., Rajadhyaksha, Manoj, Graham, Neil M. H., Pirozzi, Gianluca, Stahl, Neil, Yancopoulos, George D., Ardeleanu, Marius
Publicado 2019

A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells

por Cruz, Jonathan W., Damko, Ermelinda, Modi, Bhavika, Tu, Naxin, Meagher, Karoline, Voronina, Vera, Gartner, Hans, Ehrlich, George, Rafique, Ashique, Babb, Robert, Aneja, Priya, Potocky, Terra B., D’ Orvilliers, Amanda, Coppi, Alida, E, Sook Yen, Qiu, Haibo, Williams, Courtney M., Bennett, Brandy L., Chen, Gang, Macdonald, Lynn, Olson, William, Lin, John C., Stahl, Neil, Murphy, Andrew J., Kyratsous, Christos A., Prasad, Brinda C.
Publicado 2019

Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants

por Simões, Eric A F, Forleo-Neto, Eduardo, Geba, Gregory P, Kamal, Mohamed, Yang, Feng, Cicirello, Helen, Houghton, Matthew R, Rideman, Ronald, Zhao, Qiong, Benvin, Sarah L, Hawes, Alicia, Fuller, Erin D, Wloga, Elzbieta, Pizarro, Jose M Novoa, Munoz, Flor M, Rush, Scott A, McLellan, Jason S, Lipsich, Leah, Stahl, Neil, Yancopoulos, George D, Weinreich, David M, Kyratsous, Christos A, Sivapalasingam, Sumathi
Publicado 2020

Efficacy and Safety of Dupilumab in Adolescents With Uncontrolled Moderate to Severe Atopic Dermatitis: A Phase 3 Randomized Clinical Trial

por Simpson, Eric L., Paller, Amy S., Siegfried, Elaine C., Boguniewicz, Mark, Sher, Lawrence, Gooderham, Melinda J., Beck, Lisa A., Guttman-Yassky, Emma, Pariser, David, Blauvelt, Andrew, Weisman, Jamie, Lockshin, Benjamin, Hultsch, Thomas, Zhang, Qin, Kamal, Mohamed A., Davis, John D., Akinlade, Bolanle, Staudinger, Heribert, Hamilton, Jennifer D., Graham, Neil M. H., Pirozzi, Gianluca, Gadkari, Abhijit, Eckert, Laurent, Stahl, Neil, Yancopoulos, George D., Ruddy, Marcella, Bansal, Ashish
Publicado 2019

Virologic Efficacy of Casirivimab and Imdevimab COVID-19 Antibody Combination in Outpatients With SARS-CoV-2 Infection: A Phase 2 Dose-Ranging Randomized Clinical Trial

por Portal-Celhay, Cynthia, Forleo-Neto, Eduardo, Eagan, Will, Musser, Bret J., Davis, John D., Turner, Kenneth C., Norton, Thomas, Hooper, Andrea T., Hamilton, Jennifer D., Pan, Cynthia, Mahmood, Adnan, Baum, Alina, Kyratsous, Christos A., Kim, Yunji, Parrino, Janie, Kampman, Wendy, Roque-Guerrero, Lilia, Stoici, Roxana, Fatakia, Adil, Soo, Yuhwen, Geba, Gregory P., Kowal, Bari, DiCioccio, A. Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary A., Yancopoulos, George D., Weinreich, David M.
Publicado 2022

REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19

por Weinreich, David M., Sivapalasingam, Sumathi, Norton, Thomas, Ali, Shazia, Gao, Haitao, Bhore, Rafia, Musser, Bret J., Soo, Yuhwen, Rofail, Diana, Im, Joseph, Perry, Christina, Pan, Cynthia, Hosain, Romana, Mahmood, Adnan, Davis, John D., Turner, Kenneth C., Hooper, Andrea T., Hamilton, Jennifer D., Baum, Alina, Kyratsous, Christos A., Kim, Yunji, Cook, Amanda, Kampman, Wendy, Kohli, Anita, Sachdeva, Yessica, Graber, Ximena, Kowal, Bari, DiCioccio, Thomas, Stahl, Neil, Lipsich, Leah, Braunstein, Ned, Herman, Gary, Yancopoulos, George D.
Publicado 2020