IRF9 and unphosphorylated STAT2 cooperate with NF-κB to drive IL6 expression

por Nan, Jing, Wang, Yuxin, Yang, Jinbo, Stark, George R.
Publicado 2018

CBL0137 increases the targeting efficacy of Rovalpituzumab tesirine against tumour-initiating cells in small cell lung cancer

por Lindner, Daniel J., Wildey, Gary, Parker, Yvonne, Dowlati, Afshin, Stark, George R., De, Sarmishtha
Publicado 2020

Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM

por Wightman, Samantha M., Alban, Tyler J., Chen, Xing, Lathia, Justin D., Wang, Yuxin, Stark, George R.
Publicado 2021

Interferons at age 50: past, current and future impact on biomedicine

por Borden, Ernest C., Sen, Ganes C., Uze, Gilles, Silverman, Robert H., Ransohoff, Richard M., Foster, Graham R., Stark, George R.
Publicado 2007

Pharmacological Inhibition of BACE1 Suppresses Glioblastoma Growth by Stimulating Macrophage Phagocytosis of Tumor Cells

por Zhai, Kui, Huang, Zhi, Huang, Qian, Tao, Weiwei, Fang, Xiaoguang, Zhang, Aili, Li, Xiaoxia, Stark, George R., Hamilton, Thomas A., Bao, Shideng
Publicado 2021

The opposing effects of interferon-beta and oncostatin-M as regulators of cancer stem cell plasticity in triple-negative breast cancer

por Doherty, Mary R., Parvani, Jenny G., Tamagno, Ilaria, Junk, Damian J., Bryson, Benjamin L., Cheon, Hyeon Joo, Stark, George R., Jackson, Mark W.
Publicado 2019

Cooperative Transcriptional Activation of Antimicrobial Genes by STAT and NF-κB Pathways by Concerted Recruitment of the Mediator Complex

por Wienerroither, Sebastian, Shukla, Priyank, Farlik, Matthias, Majoros, Andrea, Stych, Bernadette, Vogl, Claus, Cheon, HyeonJoo, Stark, George R., Strobl, Birgit, Müller, Mathias, Decker, Thomas
Publicado 2015

Interferon-beta represses cancer stem cell properties in triple-negative breast cancer

por Doherty, Mary R., Cheon, HyeonJoo, Junk, Damian J., Vinayak, Shaveta, Varadan, Vinay, Telli, Melinda L., Ford, James M., Stark, George R., Jackson, Mark W.
Publicado 2017

STAT2 hinders STING intracellular trafficking and reshapes its activation in response to DNA damage

por Wang, Chenyao, Nan, Jing, Holvey-Bates, Elise, Chen, Xing, Wightman, Samantha, Latif, Muhammad-Bilal, Zhao, Junjie, Li, Xiaoxia, Sen, Ganes C., Stark, George R., Wang, Yuxin
Publicado 2023

Response to interferons and antibacterial innate immunity in the absence of tyrosine‐phosphorylated STAT1

por Majoros, Andrea, Platanitis, Ekaterini, Szappanos, Daniel, Cheon, HyeonJoo, Vogl, Claus, Shukla, Priyank, Stark, George R, Sexl, Veronika, Schreiber, Robert, Schindler, Christian, Müller, Mathias, Decker, Thomas
Publicado 2016

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

por Cheon, HyeonJoo, Holvey-Bates, Elise G, Schoggins, John W, Forster, Samuel, Hertzog, Paul, Imanaka, Naoko, Rice, Charles M, Jackson, Mark W, Junk, Damian J, Stark, George R
Publicado 2013

OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug

por Banerjee, Shuvojit, Gusho, Elona, Gaughan, Christina, Dong, Beihua, Gu, Xiaorong, Holvey-Bates, Elise, Talukdar, Manisha, Li, Yize, Weiss, Susan R., Sicheri, Frank, Saunthararajah, Yogen, Stark, George R., Silverman, Robert H.
Publicado 2019

A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses

por Wang, Yuxin, Song, Qiaoling, Huang, Wei, Lin, Yuxi, Wang, Xin, Wang, Chenyao, Willard, Belinda, Zhao, Chenyang, Nan, Jing, Holvey-Bates, Elise, Wang, Zhuoya, Taylor, Derek, Yang, Jinbo, Stark, George R.
Publicado 2020

Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma

por Tao, Weiwei, Chu, Chengwei, Zhou, Wenchao, Huang, Zhi, Zhai, Kui, Fang, Xiaoguang, Huang, Qian, Zhang, Aili, Wang, Xiuxing, Yu, Xingjiang, Huang, Haidong, Wu, Qiulian, Sloan, Andrew E., Yu, Jennifer S., Li, Xiaoxia, Stark, George R., Rich, Jeremy N., Bao, Shideng
Publicado 2020

Loss of ZIP facilitates JAK2-STAT3 activation in tamoxifen-resistant breast cancer

por Zhu, Ning, Zhang, Jing, Du, Yuping, Qin, Xiaodong, Miao, Ruidong, Nan, Jing, Chen, Xing, Sun, Jingjie, Zhao, Rui, Zhang, Xinxin, Shi, Lei, Li, Xin, Lin, Yuxi, Wei, Wei, Mao, Aihong, Zhang, Zhao, Stark, George R., Wang, Yuxin, Yang, Jinbo
Publicado 2020

Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

por Liao, Yun, Zhao, Junjie, Bulek, Katarzyna, Tang, Fangqiang, Chen, Xing, Cai, Gang, Jia, Shang, Fox, Paul L., Huang, Emina, Pizarro, Theresa T., Kalady, Matthew F., Jackson, Mark W., Bao, Shideng, Sen, Ganes C., Stark, George R., Chang, Christopher J., Li, Xiaoxia
Publicado 2020

H3K9 methylation drives resistance to androgen receptor–antagonist therapy in prostate cancer

por Baratchian, Mehdi, Tiwari, Ritika, Khalighi, Sirvan, Chakravarthy, Ankur, Yuan, Wei, Berk, Michael, Li, Jianneng, Guerinot, Amy, de Bono, Johann, Makarov, Vladimir, Chan, Timothy A., Silverman, Robert H., Stark, George R., Varadan, Vinay, De Carvalho, Daniel D., Chakraborty, Abhishek A., Sharifi, Nima
Publicado 2022

A novel IL-17 signaling pathway controlling keratinocyte proliferation and tumorigenesis via the TRAF4–ERK5 axis

por Wu, Ling, Chen, Xing, Zhao, Junjie, Martin, Bradley, Zepp, Jarod A., Ko, Jennifer S., Gu, Chunfang, Cai, Gang, Ouyang, Wenjun, Sen, Ganes, Stark, George R., Su, Bing, Vines, Charlotte M., Tournier, Cathy, Hamilton, Thomas A., Vidimos, Allison, Gastman, Brian, Liu, Caini, Li, Xiaoxia
Publicado 2015

Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

por Liao, Lili, Liu, Zongzhi Z, Langbein, Lauren, Cai, Weijia, Cho, Eun-Ah, Na, Jie, Niu, Xiaohua, Jiang, Wei, Zhong, Zhijiu, Cai, Wesley L, Jagannathan, Geetha, Dulaimi, Essel, Testa, Joseph R, Uzzo, Robert G, Wang, Yuxin, Stark, George R, Sun, Jianxin, Peiper, Stephen, Xu, Yaomin, Yan, Qin, Yang, Haifeng
Publicado 2018

Correction: Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer

por Liao, Lili, Liu, Zongzhi Z, Langbein, Lauren, Cai, Weijia, Cho, Eun-Ah, Na, Jie, Niu, Xiaohua, Jiang, Wei, Zhong, Zhijiu, Cai, Wesley L, Jagannathan, Geetha, Dulaimi, Essel, Testa, Joseph R, Uzzo, Robert G, Wang, Yuxin, Stark, George R, Sun, Jianxin, Peiper, Stephen C, Xu, Yaomin, Yan, Qin, Yang, Haifeng
Publicado 2021