From passage to inhibition: Uncovering the structural and physiological inhibitory mechanisms of MCUb in mitochondrial calcium regulation

por Colussi, Danielle M., Stathopulos, Peter B.
Publicado 2022

Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease

por Lin, Qi-Tong, Stathopulos, Peter B.
Publicado 2019

The 2β Splice Variation Alters the Structure and Function of the Stromal Interaction Molecule Coiled-Coil Domains

por Chung, Steve, Zhang, MengQi, Stathopulos, Peter B.
Publicado 2018

The human MRS2 magnesium-binding domain is a regulatory feedback switch for channel activity

por Uthayabalan, Sukanthathulse, Vishnu, Neelanjan, Madesh, Muniswamy, Stathopulos, Peter B
Publicado 2023

The Hydrophobic Residues in Amino Terminal Domains of Cx46 and Cx50 Are Important for Their Gap Junction Channel Ion Permeation and Gating

por Jaradat, Roa’a, Li, Xiaole, Chen, Honghong, Stathopulos, Peter B., Bai, Donglin
Publicado 2022

Synergistic stabilization by nitrosoglutathione-induced thiol modifications in the stromal interaction molecule-2 luminal domain suppresses basal and store operated calcium entry

por Novello, Matthew J., Zhu, Jinhui, Zhang, MengQi, Feng, Qingping, Stathopulos, Peter B.
Publicado 2020

A dual mechanism promotes switching of the Stormorken STIM1 R304W mutant into the activated state

por Fahrner, Marc, Stadlbauer, Michael, Muik, Martin, Rathner, Petr, Stathopulos, Peter, Ikura, Mitsu, Müller, Norbert, Romanin, Christoph
Publicado 2018

Structural Mechanisms of Store-Operated and Mitochondrial Calcium Regulation: Initiation Points for Drug Discovery

por Noble, Megan, Lin, Qi-Tong, Sirko, Christian, Houpt, Jacob A., Novello, Matthew J., Stathopulos, Peter B.
Publicado 2020

A Coiled-coil Clamp Controls Both Conformation and Clustering of Stromal Interaction Molecule 1 (STIM1)

por Fahrner, Marc, Muik, Martin, Schindl, Rainer, Butorac, Carmen, Stathopulos, Peter, Zheng, Le, Jardin, Isaac, Ikura, Mitsuhiko, Romanin, Christoph
Publicado 2014

STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry

por Stathopulos, Peter B., Schindl, Rainer, Fahrner, Marc, Zheng, Le, Gasmi-Seabrook, Geneviève M., Muik, Martin, Romanin, Christoph, Ikura, Mitsuhiko
Publicado 2013

Differential Domain Distribution of gnomAD- and Disease-Linked Connexin Missense Variants

por Bai, Donglin, Wang, Jiayi, Li, Tianhe, Chan, Ryan, Atalla, Mena, Chen, Robert C., Khazaneh, Mohammad T., An, Raphael J., Stathopulos, Peter B.
Publicado 2021

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation

por Muik, Martin, Fahrner, Marc, Schindl, Rainer, Stathopulos, Peter, Frischauf, Irene, Derler, Isabella, Plenk, Peter, Lackner, Barbara, Groschner, Klaus, Ikura, Mitsuhiko, Romanin, Christoph
Publicado 2011

Initial activation of STIM1, the regulator of store-operated calcium entry

por Zhou, Yubin, Srinivasan, Prasanna, Razavi, Shiva, Seymour, Sam, Meraner, Paul, Gudlur, Aparna, Stathopulos, Peter B, Ikura, Mitsuhiko, Rao, Anjana, Hogan, Patrick G
Publicado 2013

Structural and functional conservation of key domains in InsP(3) and ryanodine receptors

por Seo, Min-Duk, Velamakanni, Saroj, Ishiyama, Noboru, Stathopulos, Peter B., Rossi, Ana M., Khan, Samir A., Dale, Philippa, Li, Congmin, Ames, James B., Ikura, Mitsuhiko, Taylor, Colin W.
Publicado 2012

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

por Woods, Joshua J., Nemani, Neeharika, Shanmughapriya, Santhanam, Kumar, Akshay, Zhang, MengQi, Nathan, Sarah R., Thomas, Manfred, Carvalho, Edmund, Ramachandran, Karthik, Srikantan, Subramanya, Stathopulos, Peter B., Wilson, Justin J., Madesh, Muniswamy
Publicado 2019

STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells

por Kahlfuss, Sascha, Kaufmann, Ulrike, Concepcion, Axel R, Noyer, Lucile, Raphael, Dimitrius, Vaeth, Martin, Yang, Jun, Pancholi, Priya, Maus, Mate, Muller, James, Kozhaya, Lina, Khodadadi‐Jamayran, Alireza, Sun, Zhengxi, Shaw, Patrick, Unutmaz, Derya, Stathopulos, Peter B, Feist, Cori, Cameron, Scott B, Turvey, Stuart E, Feske, Stefan
Publicado 2020

Limiting Mrs2-dependent mitochondrial Mg(2+) uptake induces metabolic programming in prolonged dietary stress

por Madaris, Travis R., Venkatesan, Manigandan, Maity, Soumya, Stein, Miriam C., Vishnu, Neelanjan, Venkateswaran, Mridula K., Davis, James G., Ramachandran, Karthik, Uthayabalan, Sukanthathulse, Allen, Cristel, Osidele, Ayodeji, Stanley, Kristen, Bigham, Nicholas P., Bakewell, Terry M., Narkunan, Melanie, Le, Amy, Karanam, Varsha, Li, Kang, Mhapankar, Aum, Norton, Luke, Ross, Jean, Aslam, M. Imran, Reeves, W. Brian, Singh, Brij B., Caplan, Jeffrey, Wilson, Justin J., Stathopulos, Peter B., Baur, Joseph A., Madesh, Muniswamy
Publicado 2023