Axonal transport of late endosomes and amphisomes is selectively modulated by local Ca(2+) efflux and disrupted by PSEN1 loss of function

por Lie, Pearl P. Y., Yoo, Lang, Goulbourne, Chris N., Berg, Martin J., Stavrides, Philip, Huo, Chunfeng, Lee, Ju-Hyun, Nixon, Ralph A.
Publicado 2022

Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr(682)-phosphorylated APP βCTF

por Im, Eunju, Jiang, Ying, Stavrides, Philip H., Darji, Sandipkumar, Erdjument-Bromage, Hediye, Neubert, Thomas A., Choi, Jun Yong, Wegiel, Jerzy, Lee, Ju-Hyun, Nixon, Ralph A.
Publicado 2023

Autophagy is a novel pathway for neurofilament protein degradation in vivo

por Rao, Mala V., Darji, Sandipkumar, Stavrides, Philip H., Goulbourne, Chris N., Kumar, Asok, Yang, Dun-Sheng, Yoo, Lang, Peddy, James, Lee, Ju-Hyun, Yuan, Aidong, Nixon, Ralph A.
Publicado 2022

Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

por Lee, Ju-Hyun, Yang, Dun-Sheng, Goulbourne, Chris N., Im, Eunju, Stavrides, Philip, Pensalfini, Anna, Chan, Han, Bouchet-Marquis, Cedric, Bleiwas, Cynthia, Berg, Martin J., Huo, Chunfeng, Peddy, James, Pawlik, Monika, Levy, Efrat, Rao, Mala, Staufenbiel, Mathias, Nixon, Ralph A.
Publicado 2022

Preclinical and randomized clinical evaluation of the p38α kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration

por Jiang, Ying, Alam, John J., Gomperts, Stephen N., Maruff, Paul, Lemstra, Afina W., Germann, Ursula A., Stavrides, Philip H., Darji, Sandipkumar, Malampati, Sandeep, Peddy, James, Bleiwas, Cynthia, Pawlik, Monika, Pensalfini, Anna, Yang, Dun-Sheng, Subbanna, Shivakumar, Basavarajappa, Balapal S., Smiley, John F., Gardner, Amanda, Blackburn, Kelly, Chu, Hui-May, Prins, Niels D., Teunissen, Charlotte E., Harrison, John E., Scheltens, Philip, Nixon, Ralph A.
Publicado 2022