New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism

por Szarowicz, Carlye A., Steece-Collier, Kathy, Caulfield, Margaret E.
Publicado 2022

Repairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic

por Mercado, Natosha M, Collier, Timothy J, Freeman, Thomas, Steece-Collier, Kathy
Publicado 2016

Cell therapy for Parkinson's disease: Why it doesn't work every time

por Collier, Timothy J., Sortwell, Caryl E., Mercado, Natosha M., Steece‐Collier, Kathy
Publicado 2019

Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates

por Collier, Timothy J., Redmond, D. Eugene, Steece-Collier, Kathy, Lipton, Jack W., Manfredsson, Fredric P.
Publicado 2016

Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration

por Madhavan, Lalitha, Daley, Brian F., Davidson, Beverly L., Boudreau, Ryan L., Lipton, Jack W., Cole-Strauss, Allyson, Steece-Collier, Kathy, Collier, Timothy J.
Publicado 2015

Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia

por Steece‐Collier, Kathy, Stancati, Jennifer A., Collier, Nicholas J., Sandoval, Ivette M., Mercado, Natosha M., Sortwell, Caryl E., Collier, Timothy J., Manfredsson, Fredric P.
Publicado 2019

Downregulation of striatal Ca(V)1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age

por Caulfield, Margaret E., Werp, Molly J. Vander, Stancati, Jennifer A., Collier, Timothy J., Sortwell, Caryl E., Sandoval, Ivette M., Manfredsson, Fredric P., Steece-Collier, Kathy
Publicado 2023

Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia

por Sellnow, Rhyomi C., Newman, Jordan H., Chambers, Nicole, West, Anthony R., Steece-Collier, Kathy, Sandoval, Ivette M., Benskey, Matthew J., Bishop, Christopher, Manfredsson, Fredric P.
Publicado 2019

High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine

por Fischer, D. Luke, Collier, Timothy J., Cole-Strauss, Allyson, Wohlgenant, Susan L., Lipton, Jack W., Steece-Collier, Kathy, Manfredsson, Fredric P., Kemp, Christopher J., Sortwell, Caryl E.
Publicado 2015

Impact of age and vector construct on striatal and nigral transgene expression

por Polinski, Nicole K, Manfredsson, Fredric P, Benskey, Matthew J, Fischer, D Luke, Kemp, Christopher J, Steece-Collier, Kathy, Sandoval, Ivette M, Paumier, Katrina L, Sortwell, Caryl E
Publicado 2016

The Longitudinal Transcriptomic Response of the Substantia Nigra to Intrastriatal 6-Hydroxydopamine Reveals Significant Upregulation of Regeneration-Associated Genes

por Kanaan, Nicholas M., Collier, Timothy J., Cole-Strauss, Allyson, Grabinski, Tessa, Mattingly, Zachary R., Winn, Mary E., Steece-Collier, Kathy, Sortwell, Caryl E., Manfredsson, Fredric P., Lipton, Jack W.
Publicado 2015

Striatal Afferent BDNF Is Disrupted by Synucleinopathy and Partially Restored by STN DBS

por Miller, Kathryn M., Patterson, Joseph R., Kochmanski, Joseph, Kemp, Christopher J., Stoll, Anna C., Onyekpe, Christopher U., Cole-Strauss, Allyson, Steece-Collier, Kathy, Howe, Jacob W., Luk, Kelvin C., Sortwell, Caryl E.
Publicado 2021

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats

por Mercado, Natosha M., Stancati, Jennifer A., Sortwell, Caryl E., Mueller, Rebecca L., Boezwinkle, Samuel A., Duffy, Megan F., Fischer, D. Luke, Sandoval, Ivette M., Manfredsson, Fredric P., Collier, Timothy J., Steece-Collier, Kathy
Publicado 2020

Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression

por Fischer, D. Luke, Manfredsson, Fredric P., Kemp, Christopher J., Cole-Strauss, Allyson, Lipton, Jack W., Duffy, Megan F., Polinski, Nicole K., Steece-Collier, Kathy, Collier, Timothy J., Gombash, Sara E., Buhlinger, Daniel J., Sortwell, Caryl E.
Publicado 2017

A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates

por Anwer, Danish M., Gubinelli, Francesco, Kurt, Yunus A., Sarauskyte, Livija, Jacobs, Febe, Venuti, Chiara, Sandoval, Ivette M., Yang, Yiyi, Stancati, Jennifer, Mazzocchi, Martina, Brandi, Edoardo, O’Keeffe, Gerard, Steece-Collier, Kathy, Li, Jia-Yi, Deierborg, Tomas, Manfredsson, Fredric P., Davidsson, Marcus, Heuer, Andreas
Publicado 2023

Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia

por Bartlett, Mitchell J., Flores, Andrew J., Ye, Tony, Smidt, Saskia I., Dollish, Hannah K., Stancati, Jennifer A., Farrell, Drew C., Parent, Kate L., Doyle, Kristian P., Besselsen, David G., Heien, Michael L., Cowen, Stephen L., Steece-Collier, Kathy, Sherman, Scott J., Falk, Torsten
Publicado 2020

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein

por Patterson, Joseph R., Hirst, Warren D., Howe, Jacob W., Russell, Christopher P., Cole-Strauss, Allyson, Kemp, Christopher J., Duffy, Megan F., Lamp, Jared, Umstead, Andrew, Kubik, Michael, Stoll, Anna C., Vega, Irving E., Steece-Collier, Kathy, Chen, Yi, Campbell, Anne C., Nezich, Catherine L., Glajch, Kelly E., Sortwell, Caryl E.
Publicado 2022

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease

por Cole, Tracy A., Zhao, Hien, Collier, Timothy J., Sandoval, Ivette, Sortwell, Caryl E., Steece-Collier, Kathy, Daley, Brian F., Booms, Alix, Lipton, Jack, Welch, Mackenzie, Berman, Melissa, Jandreski, Luke, Graham, Danielle, Weihofen, Andreas, Celano, Stephanie, Schulz, Emily, Cole-Strauss, Allyson, Luna, Esteban, Quach, Duc, Mohan, Apoorva, Bennett, C. Frank, Swayze, Eric E., Kordasiewicz, Holly B., Luk, Kelvin C., Paumier, Katrina L.
Publicado 2021