Structures, Substrates, and Regulators of Mammalian Sirtuins – Opportunities and Challenges for Drug Development

por Moniot, Sébastien, Weyand, Michael, Steegborn, Clemens
Publicado 2012

Structure-based development of novel sirtuin inhibitors

por Schlicker, Christine, Boanca, Gina, Lakshminarasimhan, Mahadevan, Steegborn, Clemens
Publicado 2011

Sirt1 activation by resveratrol is substrate sequence-selective

por Lakshminarasimhan, Mahadevan, Rauh, David, Schutkowski, Mike, Steegborn, Clemens
Publicado 2013

Sirt4: A Multifaceted Enzyme at the Crossroads of Mitochondrial Metabolism and Cancer

por Tomaselli, Daniela, Steegborn, Clemens, Mai, Antonello, Rotili, Dante
Publicado 2020

Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc

por Gertz, Melanie, Fischer, Frank, Leipelt, Martina, Wolters, Dirk, Steegborn, Clemens
Publicado 2009

Structural and mechanistic insights into cGMP signaling

por Rauch, Annika, Russwurm, Michael, Schlicker, Christine, Leipelt, Martina, Steegborn, Clemens
Publicado 2009

Identification of a haem domain in human soluble adenylate cyclase

por Middelhaufe, Sabine, Leipelt, Martina, Levin, Lonny R., Buck, Jochen, Steegborn, Clemens
Publicado 2012

Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives

por You, Weijie, Zheng, Wei, Weiss, Sandra, Chua, Katrin F., Steegborn, Clemens
Publicado 2019

Sirt5 Deacylation Activities Show Differential Sensitivities to Nicotinamide Inhibition

por Fischer, Frank, Gertz, Melanie, Suenkel, Benjamin, Lakshminarasimhan, Mahadevan, Schutkowski, Mike, Steegborn, Clemens
Publicado 2012

Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol

por Lakshminarasimhan, Mahadevan, Curth, Ute, Moniot, Sebastien, Mosalaganti, Shyamal, Raunser, Stefan, Steegborn, Clemens
Publicado 2013

Insights into the Mechanism of Human Deiodinase 1

por Rodriguez-Ruiz, Alfonso, Braun, Doreen, Pflug, Simon, Brol, Alexander, Sylvester, Marc, Steegborn, Clemens, Schweizer, Ulrich
Publicado 2022

Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein

por Weiss, Sandra, Adolph, Ramona S., Schweimer, Kristian, DiFonzo, Andrea, Meleshin, Marat, Schutkowski, Mike, Steegborn, Clemens
Publicado 2022

Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features

por Pannek, Martin, Simic, Zeljko, Fuszard, Matthew, Meleshin, Marat, Rotili, Dante, Mai, Antonello, Schutkowski, Mike, Steegborn, Clemens
Publicado 2017

Effects of 3‐Bromo‐4,5‐dihydroisoxazole Derivatives on Nrf2 Activation and Heme Oxygenase‐1 Expression

por Pinto, Andrea, El Ali, Zeina, Moniot, Sébastien, Tamborini, Lucia, Steegborn, Clemens, Foresti, Roberta, De Micheli, Carlo
Publicado 2018

Optimization of lead compounds into on-demand, nonhormonal contraceptives: leveraging a public–private drug discovery institute collaboration(†)

por Balbach, Melanie, Fushimi, Makoto, Huggins, David J, Steegborn, Clemens, Meinke, Peter T, Levin, Lonny R, Buck, Jochen
Publicado 2020

Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein

por Adolph, Ramona S., Beck, Eileen, Schweimer, Kristian, Di Fonzo, Andrea, Weyand, Michael, Rösch, Paul, Wöhrl, Birgitta M., Steegborn, Clemens
Publicado 2023

Corrigendum: Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

por Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W., Meinke, Peter T., Levin, Lonny R., Buck, Jochen
Publicado 2023

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

por Rossetti, Thomas, Ferreira, Jacob, Ghanem, Lubna, Buck, Hannes, Steegborn, Clemens, Myers, Robert W., Meinke, Peter T., Levin, Lonny R., Buck, Jochen
Publicado 2022

A continuous sirtuin activity assay without any coupling to enzymatic or chemical reactions

por Schuster, Sabine, Roessler, Claudia, Meleshin, Marat, Zimmermann, Philipp, Simic, Zeljko, Kambach, Christian, Schiene-Fischer, Cordelia, Steegborn, Clemens, Hottiger, Michael O., Schutkowski, Mike
Publicado 2016

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

por Teodoro, João S., Amorim, João A., Machado, Ivo F., Castela, Ana C., Steegborn, Clemens, Sinclair, David A., Rolo, Anabela P., Palmeira, Carlos M.
Publicado 2020