Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia

por Blunt, Matthew D., Steele, Andrew J.
Publicado 2015

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

por Arthur, Rachael, Valle-Argos, Beatriz, Steele, Andrew J., Packham, Graham
Publicado 2020

Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease

por Steele, Andrew J., Denaxas, Spiros C., Shah, Anoop D., Hemingway, Harry, Luscombe, Nicholas M.
Publicado 2018

A gene-expression-based neural code for food abundance that modulates lifespan

por Entchev, Eugeni V, Patel, Dhaval S, Zhan, Mei, Steele, Andrew J, Lu, Hang, Ch'ng, QueeLim
Publicado 2015

Clinical impact of ibrutinib plus R-CHOP in untreated DLBCL coexpressing BCL2 and MYC in the phase 3 PHOENIX trial

por Johnson, Peter W. M., Balasubramanian, Sriram, Hodkinson, Brendan, Shreeve, S. Martin, Sun, Steven, Srinivasan, Srimathi, Steele, Andrew J., Vermeulen, Jessica, Sehn, Laurie H., Wilson, Wyndham H.
Publicado 2023

Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells

por Wilmore, Sarah, Rogers-Broadway, Karly-Rai, Taylor, Joe, Lemm, Elizabeth, Fell, Rachel, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Coldwell, Mark, Packham, Graham, Yeomans, Alison
Publicado 2021

Anti-vascular agent Combretastatin A-4-P modulates Hypoxia Inducible Factor-1 and gene expression

por Dachs, Gabi U, Steele, Andrew J, Coralli, Claudia, Kanthou, Chryso, Brooks, Andrew C, Gunningham, Sarah P, Currie, Margaret J, Watson, Ally I, Robinson, Bridget A, Tozer, Gillian M
Publicado 2006

Tumour Cells Expressing Single VEGF Isoforms Display Distinct Growth, Survival and Migration Characteristics

por Kanthou, Chryso, Dachs, Gabi U., Lefley, Diane V., Steele, Andrew J., Coralli-Foxon, Claudia, Harris, Sheila, Greco, Olga, Dos Santos, Sofia A., Reyes-Aldasoro, Constantino C., English, William R., Tozer, Gillian M.
Publicado 2014

B-cell receptor dependent phagocytosis and presentation of particulate antigen by chronic lymphocytic leukemia cells

por Minton, Annabel R., Smith, Lindsay D., Bryant, Dean J., Strefford, Jonathan C., Forconi, Francesco, Stevenson, Freda K., Tumbarello, David A., James, Edd, Løset, Geir Åge, Munthe, Ludvig A., Steele, Andrew J., Packham, Graham
Publicado 2022

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL

por Bryant, Dean, Smith, Lindsay, Rogers-Broadway, Karly Rai, Karydis, Laura, Woo, Jeongmin, Blunt, Matthew D., Forconi, Francesco, Stevenson, Freda K., Goodnow, Christopher, Russell, Amanda, Humburg, Peter, Packham, Graham, Steele, Andrew J., Strefford, Jonathan C.
Publicado 2023

B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

por Taylor, Joe, Wilmore, Sarah, Marriot, Sophie, Rogers-Broadway, Karly-Rai, Fell, Rachel, Minton, Annabel R., Branch, Tom, Ashton-Key, Meg, Coldwell, Mark, Stevenson, Freda K., Forconi, Francesco, Steele, Andrew J., Packham, Graham, Yeomans, Alison
Publicado 2022

PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2α phosphorylation in established cell lines and primary human leukemia...

por Yeomans, Alison, Lemm, Elizabeth, Wilmore, Sarah, Cavell, Breeze E., Valle-Argos, Beatriz, Krysov, Sergey, Hidalgo, Marina Sanchez, Leonard, Elodie, Willis, Anne E., Forconi, Francesco, Stevenson, Freda K., Steele, Andrew J., Coldwell, Mark J., Packham, Graham
Publicado 2016

Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

por Brace, Patience T., Tezera, Liku B., Bielecka, Magdalena K., Mellows, Toby, Garay, Diana, Tian, Shuye, Rand, Lucinda, Green, Justin, Jogai, Sanjay, Steele, Andrew J., Millar, Timothy M., Sanchez-Elsner, Tilman, Friedland, Jon S., Proud, Christopher G., Elkington, Paul T.
Publicado 2017

Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells

por Linley, Adam J., Karydis, Laura I., Mondru, Anil K., D'Avola, Annalisa, Al Shmrany, Humood, Cicconi, Silvia, Griffin, Rebecca, Forconi, Francesco, Pettitt, Andrew R., Kalakonda, Nagesh, Rawstron, Andrew C., Hillmen, Peter, Steele, Andrew J., MacEwan, David J., Packham, Graham, Prior, Ian A., Slupsky, Joseph R.
Publicado 2021

Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis

por Hill, Charlotte, Li, Juanjuan, Liu, Dian, Conforti, Franco, Brereton, Christopher J., Yao, Liudi, Zhou, Yilu, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Ottensmeier, Christian H., Steele, Andrew J., Downward, Julian, Richeldi, Luca, Lu, Xin, Davies, Donna E., Jones, Mark G., Wang, Yihua
Publicado 2019

BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia

por Smith, Lindsay D., Minton, Annabel R., Blunt, Matthew D., Karydis, Laura I., Dutton, David A., Rogers-Broadway, Karly-Rai, Dobson, Rachel, Liu, Rena, Norster, Faith, Hogg, Elizabeth, Ashton-Key, Margaret, Strefford, Jonathan C., Jia, Li, Efremov, Dimitar G., Helgason, G. Vignir, Johnson, Peter W. M., Stevenson, Freda K., Forconi, Francesco, Cragg, Mark S., Tumbarello, David A., Packham, Graham, Steele, Andrew J.
Publicado 2019

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial

por Blakemore, Stuart J., Clifford, Ruth, Parker, Helen, Antoniou, Pavlos, Stec-Dziedzic, Ewa, Larrayoz, Marta, Davis, Zadie, Kadalyayil, Latha, Colins, Andrew, Robbe, Pauline, Vavoulis, Dimitris, Forster, Jade, Carr, Louise, Morilla, Ricardo, Else, Monica, Bryant, Dean, McCarthy, Helen, Walewska, Renata J., Steele, Andrew J., Chan, Jacqueline, Speight, Graham, Stankovic, Tanja, Cragg, Mark S., Catovsky, Daniel, Oscier, David G., Rose-Zerilli, Matthew J. J., Schuh, Anna, Strefford, Jonathan C.
Publicado 2020