Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

por Nilsson, Maria, Dahlman-Wright, Karin, Karelmo, Charlotta, Gustafsson, Jan-Åke, Steffensen, Knut R.
Publicado 2007

Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter

por Nilsson, Maria, Dahlman-Wright, Karin, Karelmo, Charlotta, Ebeling, Martin, Gustafsson, Jan-Åke, Steffensen, Knut R.
Publicado 2008

Liver X Receptor Regulation of Thyrotropin-Releasing Hormone Transcription in Mouse Hypothalamus Is Dependent on Thyroid Status

por Ghaddab-Zroud, Rym, Seugnet, Isabelle, Steffensen, Knut R., Demeneix, Barbara A., Clerget-Froidevaux, Marie-Stéphanie
Publicado 2014

Human NCU-G1 can function as a transcription factor and as a nuclear receptor co-activator

por Steffensen, Knut R, Bouzga, Mariam, Skjeldal, Frode, Kasi, Cecilie, Karahasan, Almira, Matre, Vilborg, Bakke, Oddmund, Guérin, Sylvain, Eskild, Winnie
Publicado 2007

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages

por Pehkonen, Petri, Welter-Stahl, Lynn, Diwo, Janine, Ryynänen, Jussi, Wienecke-Baldacchino, Anke, Heikkinen, Sami, Treuter, Eckardt, Steffensen, Knut R, Carlberg, Carsten
Publicado 2012

Nuclear Hormone Receptor LXRα Inhibits Adipocyte Differentiation of Mesenchymal Stem Cells with Wnt/beta-catenin Signaling

por Matsushita, Kenichi, Morello, Fulvio, Zhang, Zhiping, Masuda, Tomoko, Iwanaga, Shiro, Steffensen, Knut R., Gustafsson, Jan-Åke, Pratt, Richard E., Dzau, Victor J.
Publicado 2015

Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

por Hellemans, Karine H., Hannaert, Jean-Claude, Denys, Bart, Steffensen, Knut R., Raemdonck, Cindy, Martens, Geert A., Van Veldhoven, Paul P., Gustafsson, Jan-Åke, Pipeleers, Daniel
Publicado 2009

The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms

por Pourcet, Benoit, Gage, Matthew C., León, Theresa E., Waddington, Kirsty E., Pello, Oscar M., Steffensen, Knut R., Castrillo, Antonio, Valledor, Annabel F., Pineda-Torra, Inés
Publicado 2016

Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice

por Pedrelli, Matteo, Davoodpour, Padideh, Degirolamo, Chiara, Gomaraschi, Monica, Graham, Mark, Ossoli, Alice, Larsson, Lilian, Calabresi, Laura, Gustafsson, Jan-Åke, Steffensen, Knut R., Eriksson, Mats, Parini, Paolo
Publicado 2014

LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

por Cannon, Megan V., Silljé, Herman H. W., Sijbesma, Jürgen W. A., Khan, Mohsin A. F., Steffensen, Knut R., van Gilst, Wiek H., de Boer, Rudolf A.
Publicado 2015

Cholesterol‐sensing liver X receptors stimulate Th2‐driven allergic eosinophilic asthma in mice

por Smet, Muriel, Van Hoecke, Lien, De Beuckelaer, Ans, Vander Beken, Seppe, Naessens, Thomas, Vergote, Karl, Willart, Monique, Lambrecht, Bart N., Gustafsson, Jan‐Åke, Steffensen, Knut R., Grooten, Johan
Publicado 2016

Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles – a cohort study

por Dahlman, Ingrid, Nilsson, Maria, Gu, Harvest F, Lecoeur, Cecile, Efendic, Suad, Östenson, Claes G, Brismar, Kerstin, Gustafsson, Jan-Åke, Froguel, Philippe, Vaxillaire, Martine, Dahlman-Wright, Karin, Steffensen, Knut R
Publicado 2009

Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation

por Bogie, Jeroen F. J., Timmermans, Silke, Huynh-Thu, Vân Anh, Irrthum, Alexandre, Smeets, Hubert J. M., Gustafsson, Jan-Åke, Steffensen, Knut R., Mulder, Monique, Stinissen, Piet, Hellings, Niels, Hendriks, Jerome J. A.
Publicado 2012

Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism

por Nguyen-Vu, Trang, Vedin, Lise-Lotte, Liu, Ka, Jonsson, Philip, Lin, Jean Z, Candelaria, Nicholes R, Candelaria, Lindsay P, Addanki, Sridevi, Williams, Cecilia, Gustafsson, Jan-Åke, Steffensen, Knut R, Lin, Chin-Yo
Publicado 2013

Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function

por Wouters, Elien, de Wit, Nienke M., Vanmol, Jasmine, van der Pol, Susanne M. A., van het Hof, Bert, Sommer, Daniela, Loix, Melanie, Geerts, Dirk, Gustafsson, Jan Ake, Steffensen, Knut R., Vanmierlo, Tim, Bogie, Jeroen F. J., Hendriks, Jerome J. A., de Vries, Helga E.
Publicado 2019

Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease

por Becares, Natalia, Gage, Matthew C., Voisin, Maud, Shrestha, Elina, Martin-Gutierrez, Lucia, Liang, Ning, Louie, Rikah, Pourcet, Benoit, Pello, Oscar M., Luong, Tu Vinh, Goñi, Saioa, Pichardo-Almarza, Cesar, Røberg-Larsen, Hanne, Diaz-Zuccarini, Vanessa, Steffensen, Knut R., O’Brien, Alastair, Garabedian, Michael J., Rombouts, Krista, Treuter, Eckardt, Pineda-Torra, Inés
Publicado 2019

Insights From Liver‐Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR‐Agonist Pharmacodynamics in Humans

por Minniti, Mirko E., Pedrelli, Matteo, Vedin, Lise‐Lotte, Delbès, Anne‐Sophie, Denis, Raphaël G.P., Öörni, Katariina, Sala, Claudia, Pirazzini, Chiara, Thiagarajan, Divya, Nurmi, Harri J., Grompe, Markus, Mills, Kevin, Garagnani, Paolo, Ellis, Ewa C.S., Strom, Stephen C., Luquet, Serge H., Wilson, Elizabeth M., Bial, John, Steffensen, Knut R., Parini, Paolo
Publicado 2020

Antiproliferative Effects and Mechanisms of Liver X Receptor Ligands in Pancreatic Ductal Adenocarcinoma Cells

por Candelaria, Nicholes R., Addanki, Sridevi, Zheng, Jine, Nguyen-Vu, Trang, Karaboga, Husna, Dey, Prasenjit, Gabbi, Chiara, Vedin, Lise-Lotte, Liu, Ka, Wu, Wanfu, Jonsson, Philip K., Lin, Jean Z., Su, Fei, Bollu, Lakshmi Reddy, Hodges, Sally E., McElhany, Amy L., Issazadeh, Mehdi A., Fisher, William E., Ittmann, Michael M., Steffensen, Knut R., Gustafsson, Jan-Åke, Lin, Chin-Yo
Publicado 2014

The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

por Raccosta, Laura, Fontana, Raffaella, Maggioni, Daniela, Lanterna, Claudia, Villablanca, Eduardo J., Paniccia, Aida, Musumeci, Andrea, Chiricozzi, Elena, Trincavelli, Maria Letizia, Daniele, Simona, Martini, Claudia, Gustafsson, Jan-Ake, Doglioni, Claudio, Feo, Safiyè Gonzalvo, Leiva, Andrea, Ciampa, Maria Grazia, Mauri, Laura, Sensi, Cristina, Prinetti, Alessandro, Eberini, Ivano, Mora, J. Rodrigo, Bordignon, Claudio, Steffensen, Knut R., Sonnino, Sandro, Sozzani, Silvano, Traversari, Catia, Russo, Vincenzo
Publicado 2013