Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut peptide secretion

por Maciejewski, Benjamin S, Manion, Tara B, Steppan, Claire M
Publicado 2017

Accelerating SLC Transporter Research: Streamlining Knowledge and Validated Tools

por Wiedmer, Tabea, Ingles‐Prieto, Alvaro, Goldmann, Ulrich, Steppan, Claire M., Superti‐Furga, Giulio
Publicado 2022

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

por Greasley, Samantha E., Noell, Stephen, Plotnikova, Olga, Ferre, RoseAnn, Liu, Wei, Bolanos, Ben, Fennell, Kimberly, Nicki, Jennifer, Craig, Tim, Zhu, Yuao, Stewart, Al E., Steppan, Claire M.
Publicado 2022

Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study

por Zhu, Yuao, Binder, Joe, Yurgelonis, Irina, Rai, Devendra K., Lazarro, Sarah, Costales, Chester, Kobylarz, Keith, McMonagle, Patricia, Steppan, Claire M., Aschenbrenner, Lisa, Anderson, Annaliesa S., Cardin, Rhonda D.
Publicado 2022

Modeling the Mechanism of Action of a DGAT1 Inhibitor Using a Causal Reasoning Platform

por Enayetallah, Ahmed E., Ziemek, Daniel, Leininger, Michael T., Randhawa, Ranjit, Yang, Jianxin, Manion, Tara B., Mather, Dawn E., Zavadoski, William J., Kuhn, Max, Treadway, Judith L., des Etages, Shelly Ann G., Gibbs, E. Michael, Greene, Nigel, Steppan, Claire M.
Publicado 2011

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL(pro) inhibitor PF-00835231 as a potential new treatment for COVID-19

por de Vries, Maren, Mohamed, Adil S, Prescott, Rachel A, Valero-Jimenez, Ana M, Desvignes, Ludovic, O’Connor, Rebecca, Steppan, Claire, Devlin, Joseph C, Ivanova, Ellie, Herrera, Alberto, Schinlever, Austin, Loose, Paige, Ruggles, Kelly, Koralov, Sergei B, Anderson, Annaliesa S., Binder, Joseph, Dittmann, Meike
Publicado 2021

A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CL(pro) Inhibitor PF-00835231 as a Potential New Treatment for COVID-19

por de Vries, Maren, Mohamed, Adil S., Prescott, Rachel A., Valero-Jimenez, Ana M., Desvignes, Ludovic, O’Connor, Rebecca, Steppan, Claire, Devlin, Joseph C., Ivanova, Ellie, Herrera, Alberto, Schinlever, Austin, Loose, Paige, Ruggles, Kelly, Koralov, Sergei B., Anderson, Annaliesa S., Binder, Joseph, Dittmann, Meike
Publicado 2021

BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

por Bollinger, Eliza, Peloquin, Matthew, Libera, Jenna, Albuquerque, Bina, Pashos, Evanthia, Shipstone, Arun, Hadjipanayis, Angela, Sun, Zhongyuan, Xing, Gang, Clasquin, Michelle, Stansfield, John C., Tierney, Brendan, Gernhardt, Steven, Siddall, C. Parker, Greizer, Timothy, Geoly, Frank J., Vargas, Sarah R., Gao, Lily C., Williams, George, Marshall, Mackenzie, Rosado, Amy, Steppan, Claire, Filipski, Kevin J., Zhang, Bei B., Miller, Russell A., Roth Flach, Rachel J.
Publicado 2022

An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters

por Dvorak, Vojtech, Wiedmer, Tabea, Ingles-Prieto, Alvaro, Altermatt, Patrick, Batoulis, Helena, Bärenz, Felix, Bender, Eckhard, Digles, Daniela, Dürrenberger, Franz, Heitman, Laura H., IJzerman, Adriaan P., Kell, Douglas B., Kickinger, Stefanie, Körzö, Daniel, Leippe, Philipp, Licher, Thomas, Manolova, Vania, Rizzetto, Riccardo, Sassone, Francesca, Scarabottolo, Lia, Schlessinger, Avner, Schneider, Vanessa, Sijben, Hubert J., Steck, Anna-Lena, Sundström, Hanna, Tremolada, Sara, Wilhelm, Maria, Wright Muelas, Marina, Zindel, Diana, Steppan, Claire M., Superti-Furga, Giulio
Publicado 2021

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

por Boras, Britton, Jones, Rhys M., Anson, Brandon J., Arenson, Dan, Aschenbrenner, Lisa, Bakowski, Malina A., Beutler, Nathan, Binder, Joseph, Chen, Emily, Eng, Heather, Hammond, Holly, Hammond, Jennifer, Haupt, Robert E., Hoffman, Robert, Kadar, Eugene P., Kania, Rob, Kimoto, Emi, Kirkpatrick, Melanie G., Lanyon, Lorraine, Lendy, Emma K., Lillis, Jonathan R., Logue, James, Luthra, Suman A., Ma, Chunlong, Mason, Stephen W., McGrath, Marisa E., Noell, Stephen, Obach, R. Scott, O’ Brien, Matthew N., O’Connor, Rebecca, Ogilvie, Kevin, Owen, Dafydd, Pettersson, Martin, Reese, Matthew R., Rogers, Thomas F., Rosales, Romel, Rossulek, Michelle I., Sathish, Jean G., Shirai, Norimitsu, Steppan, Claire, Ticehurst, Martyn, Updyke, Lawrence W., Weston, Stuart, Zhu, Yuao, White, Kris M., García-Sastre, Adolfo, Wang, Jun, Chatterjee, Arnab K., Mesecar, Andrew D., Frieman, Matthew B., Anderson, Annaliesa S., Allerton, Charlotte
Publicado 2021