Structural Optimization of BIPPO Analogs as Potent Antimalarials

por Zheng, Yang, Matheeussen, An, Maes, Louis, Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Publicado 2023

Structure‐Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi

por Sijm, Maarten, Sterk, Geert Jan, Caljon, Guy, Maes, Louis, de Esch, Iwan J. P., Leurs, Rob
Publicado 2020

Structure Activity Relationship of N-Substituted Phenyldihydropyrazolones Against Trypanosoma cruzi Amastigotes

por Sijm, Maarten, Maes, Louis, de Esch, Iwan J. P., Caljon, Guy, Sterk, Geert Jan, Leurs, Rob
Publicado 2021

Pharmacological Validation of Trypanosoma brucei Phosphodiesterases as Novel Drug Targets

por de Koning, Harry P., Gould, Matthew K., Sterk, Geert Jan, Tenor, Hermann, Kunz, Stefan, Luginbuehl, Edith, Seebeck, Thomas
Publicado 2012

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target

por Kunz, Stefan, Balmer, Vreni, Sterk, Geert Jan, Pollastri, Michael P., Leurs, Rob, Müller, Norbert, Hemphill, Andrew, Spycher, Cornelia
Publicado 2017

3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity

por Zheng, Yang, Müller, Joachim, Kunz, Stefan, Siderius, Marco, Maes, Louis, Caljon, Guy, Müller, Norbert, Hemphill, Andrew, Sterk, Geert Jan, Leurs, Rob
Publicado 2022

Identification of Phenylpyrazolone Dimers as a New Class of Anti‐Trypanosoma cruzi Agents

por Sijm, Maarten, Siciliano de Araújo, Julianna, Ramos Llorca, Alba, Orrling, Kristina, Stiny, Lydia, Matheeussen, An, Maes, Louis, de Esch, Iwan J. P., de Nazaré Correia Soeiro, Maria, Sterk, Geert Jan, Leurs, Rob
Publicado 2019

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy

por Zheng, Yang, van den Kerkhof, Magali, van der Meer, Tiffany, Gul, Sheraz, Kuzikov, Maria, Ellinger, Bernhard, de Esch, Iwan J. P., Siderius, Marco, Matheeussen, An, Maes, Louis, Sterk, Geert Jan, Caljon, Guy, Leurs, Rob
Publicado 2023

Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening

por de Heuvel, Erik, Kooistra, Albert J., Edink, Ewald, van Klaveren, Sjors, Stuijt, Jeffrey, van der Meer, Tiffany, Sadek, Payman, Mabille, Dorien, Caljon, Guy, Maes, Louis, Siderius, Marco, de Esch, Iwan J. P., Sterk, Geert Jan, Leurs, Rob
Publicado 2021

Inhibition of autotransporter biogenesis by small molecules

por Steenhuis, Maurice, Abdallah, Abdallah M., de Munnik, Sabrina M., Kuhne, Sebastiaan, Sterk, Geert‐Jan, van den Berg van Saparoea, Bart, Westerhausen, Sibel, Wagner, Samuel, van der Wel, Nicole N., Wijtmans, Maikel, van Ulsen, Peter, Jong, Wouter S. P., Luirink, Joen
Publicado 2019

Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

por Munday, Jane C., Kunz, Stefan, Kalejaiye, Titilola D., Siderius, Marco, Schroeder, Susanne, Paape, Daniel, Alghamdi, Ali H., Abbasi, Zainab, Huang, Sheng Xiang, Donachie, Anne-Marie, William, Samia, Sabra, Abdel Nasser, Sterk, Geert Jan, Botros, Sanaa S., Brown, David G., Hoffman, Charles S., Leurs, Rob, de Koning, Harry P.
Publicado 2020

To Target or Not to Target Schistosoma mansoni Cyclic Nucleotide Phosphodiesterase 4A?

por Zheng, Yang, Schroeder, Susanne, Kanev, Georgi K., Botros, Sanaa S., William, Samia, Sabra, Abdel-Nasser A., Maes, Louis, Caljon, Guy, Gil, Carmen, Martinez, Ana, Salado, Irene G., Augustyns, Koen, Edink, Ewald, Sijm, Maarten, de Heuvel, Erik, de Esch, Iwan J. P., van der Meer, Tiffany, Siderius, Marco, Sterk, Geert Jan, Brown, David, Leurs, Rob
Publicado 2023

Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity

por Blaazer, Antoni R., Singh, Abhimanyu K., de Heuvel, Erik, Edink, Ewald, Orrling, Kristina M., Veerman, Johan J. N., van den Bergh, Toine, Jansen, Chimed, Balasubramaniam, Erin, Mooij, Wouter J., Custers, Hans, Sijm, Maarten, Tagoe, Daniel N. A., Kalejaiye, Titilola D., Munday, Jane C., Tenor, Hermann, Matheeussen, An, Wijtmans, Maikel, Siderius, Marco, de Graaf, Chris, Maes, Louis, de Koning, Harry P., Bailey, David S., Sterk, Geert Jan, de Esch, Iwan J. P., Brown, David G., Leurs, Rob
Publicado 2018

Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa

por Cotman, Andrej Emanuel, Durcik, Martina, Benedetto Tiz, Davide, Fulgheri, Federica, Secci, Daniela, Sterle, Maša, Možina, Štefan, Skok, Žiga, Zidar, Nace, Zega, Anamarija, Ilaš, Janez, Peterlin Mašič, Lucija, Tomašič, Tihomir, Hughes, Diarmaid, Huseby, Douglas L., Cao, Sha, Garoff, Linnéa, Berruga Fernández, Talía, Giachou, Paraskevi, Crone, Lisa, Simoff, Ivailo, Svensson, Richard, Birnir, Bryndis, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., de la Cruz, Mercedes, Glinghammar, Björn, Lenhammar, Lena, Henderson, Sara R., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel
Publicado 2023

New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus

por Durcik, Martina, Cotman, Andrej Emanuel, Toplak, Žan, Možina, Štefan, Skok, Žiga, Szili, Petra Eva, Czikkely, Márton, Maharramov, Elvin, Vu, Thu Hien, Piras, Maria Vittoria, Zidar, Nace, Ilaš, Janez, Zega, Anamarija, Trontelj, Jurij, Pardo, Luis A., Hughes, Diarmaid, Huseby, Douglas, Berruga-Fernández, Tália, Cao, Sha, Simoff, Ivailo, Svensson, Richard, Korol, Sergiy V., Jin, Zhe, Vicente, Francisca, Ramos, Maria C., Mundy, Julia E. A., Maxwell, Anthony, Stevenson, Clare E. M., Lawson, David M., Glinghammar, Björn, Sjöström, Eva, Bohlin, Martin, Oreskär, Joanna, Alvér, Sofie, Janssen, Guido V., Sterk, Geert Jan, Kikelj, Danijel, Pal, Csaba, Tomašič, Tihomir, Peterlin Mašič, Lucija
Publicado 2023