Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention

por Li, Chunxiao, Imamura, Fumiaki, Wedekind, Roland, Stewart, Isobel D, Pietzner, Maik, Wheeler, Eleanor, Forouhi, Nita G, Langenberg, Claudia, Scalbert, Augustin, Wareham, Nicholas J
Publicado 2022

M88. EVIDENCE FOR INFLAMMATION AS A PUTATIVE SHARED MECHANISM FOR INSULIN RESISTANCE AND SCHIZOPHRENIA

por Perry, Benjamin, Burgess, Stephen, Jones, Hannah, Zammit, Stanley, Upthegrove, Rachel, Mason, Amy, Day, Felix, Stewart, Isobel, Langenberg, Claudia, Wareham, Nicholas, Jones, Peter, Khandaker, Golam
Publicado 2020

Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes

por Bowker, Nicholas, Shah, Rupal L., Sharp, Stephen J., Luan, Jian'an, Stewart, Isobel D., Wheeler, Eleanor, Ferreira, Manuel A.R., Baras, Aris, Wareham, Nicholas J., Langenberg, Claudia, Lotta, Luca A.
Publicado 2020

The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analy...

por Taylor, Kurt, McBride, Nancy, Zhao, Jian, Oddie, Sam, Azad, Rafaq, Wright, John, Andreassen, Ole A., Stewart, Isobel D., Langenberg, Claudia, Magnus, Maria Christine, Borges, Maria Carolina, Caputo, Massimo, Lawlor, Deborah A.
Publicado 2022

Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study

por Zhao, Jian, Stewart, Isobel D., Baird, Denis, Mason, Dan, Wright, John, Zheng, Jie, Gaunt, Tom R., Evans, David M., Freathy, Rachel M., Langenberg, Claudia, Warrington, Nicole M., Lawlor, Deborah A., Borges, Maria Carolina
Publicado 2023

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies

por Do, Kieu Trinh, Wahl, Simone, Raffler, Johannes, Molnos, Sophie, Laimighofer, Michael, Adamski, Jerzy, Suhre, Karsten, Strauch, Konstantin, Peters, Annette, Gieger, Christian, Langenberg, Claudia, Stewart, Isobel D., Theis, Fabian J., Grallert, Harald, Kastenmüller, Gabi, Krumsiek, Jan
Publicado 2018

Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region

por Bowker, Nicholas, Hansford, Robert, Burgess, Stephen, Foley, Christopher N., Auyeung, Victoria P.W., Erzurumluoglu, A. Mesut, Stewart, Isobel D., Wheeler, Eleanor, Pietzner, Maik, Gribble, Fiona, Reimann, Frank, Bhatnagar, Pallav, Coghlan, Matthew P., Wareham, Nicholas J., Langenberg, Claudia
Publicado 2021

Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites

por Bomba, Lorenzo, Walter, Klaudia, Guo, Qi, Surendran, Praveen, Kundu, Kousik, Nongmaithem, Suraj, Karim, Mohd Anisul, Stewart, Isobel D., Langenberg, Claudia, Danesh, John, Di Angelantonio, Emanuele, Roberts, David J., Ouwehand, Willem H., Dunham, Ian, Butterworth, Adam S., Soranzo, Nicole
Publicado 2022

Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease

por Hertel, Johannes, Harms, Amy C., Heinken, Almut, Baldini, Federico, Thinnes, Cyrille C., Glaab, Enrico, Vasco, Daniel A., Pietzner, Maik, Stewart, Isobel D., Wareham, Nicholas J., Langenberg, Claudia, Trenkwalder, Claudia, Krüger, Rejko, Hankemeier, Thomas, Fleming, Ronan M.T., Mollenhauer, Brit, Thiele, Ines
Publicado 2019

Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity

por Lotta, Luca A., Mokrosiński, Jacek, Mendes de Oliveira, Edson, Li, Chen, Sharp, Stephen J., Luan, Jian’an, Brouwers, Bas, Ayinampudi, Vikram, Bowker, Nicholas, Kerrison, Nicola, Kaimakis, Vasileios, Hoult, Diana, Stewart, Isobel D., Wheeler, Eleanor, Day, Felix R., Perry, John R.B., Langenberg, Claudia, Wareham, Nicholas J., Farooqi, I. Sadaf
Publicado 2019

Association of Genetically Enhanced Lipoprotein Lipase–Mediated Lipolysis and Low-Density Lipoprotein Cholesterol–Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes...

por Lotta, Luca A., Stewart, Isobel D., Sharp, Stephen J., Day, Felix R., Burgess, Stephen, Luan, Jian’an, Bowker, Nicholas, Cai, Lina, Li, Chen, Wittemans, Laura B. L., Kerrison, Nicola D., Khaw, Kay-Tee, McCarthy, Mark I., O’Rahilly, Stephen, Scott, Robert A., Savage, David B., Perry, John R. B., Langenberg, Claudia, Wareham, Nicholas J.
Publicado 2018

Assessing the causal association of glycine with risk of cardio-metabolic diseases

por Wittemans, Laura B. L., Lotta, Luca A., Oliver-Williams, Clare, Stewart, Isobel D., Surendran, Praveen, Karthikeyan, Savita, Day, Felix R., Koulman, Albert, Imamura, Fumiaki, Zeng, Lingyao, Erdmann, Jeanette, Schunkert, Heribert, Khaw, Kay-Tee, Griffin, Julian L., Forouhi, Nita G., Scott, Robert A., Wood, Angela M., Burgess, Stephen, Howson, Joanna M. M., Danesh, John, Wareham, Nicholas J., Butterworth, Adam S., Langenberg, Claudia
Publicado 2019

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis

por Lotta, Luca A., Scott, Robert A., Sharp, Stephen J., Burgess, Stephen, Luan, Jian’an, Tillin, Therese, Schmidt, Amand F., Imamura, Fumiaki, Stewart, Isobel D., Perry, John R. B., Marney, Luke, Koulman, Albert, Karoly, Edward D., Forouhi, Nita G., Sjögren, Rasmus J. O., Näslund, Erik, Zierath, Juleen R., Krook, Anna, Savage, David B., Griffin, Julian L., Chaturvedi, Nishi, Hingorani, Aroon D., Khaw, Kay-Tee, Barroso, Inês, McCarthy, Mark I., O’Rahilly, Stephen, Wareham, Nicholas J., Langenberg, Claudia
Publicado 2016

Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study

por Cardona, Alexia, Day, Felix R., Perry, John R.B., Loh, Marie, Chu, Audrey Y., Lehne, Benjamin, Paul, Dirk S., Lotta, Luca A., Stewart, Isobel D., Kerrison, Nicola D., Scott, Robert A., Khaw, Kay-Tee, Forouhi, Nita G., Langenberg, Claudia, Liu, Chunyu, Mendelson, Michael M., Levy, Daniel, Beck, Stephan, Leslie, R. David, Dupuis, Josée, Meigs, James B., Kooner, Jaspal S., Pihlajamäki, Jussi, Vaag, Allan, Perfilyev, Alexander, Ling, Charlotte, Hivert, Marie-France, Chambers, John C., Wareham, Nicholas J., Ong, Ken K.
Publicado 2019

Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution

por Koprulu, Mine, Zhao, Yajie, Wheeler, Eleanor, Dong, Liang, Rocha, Nuno, Li, Chen, Griffin, John D, Patel, Satish, Van de Streek, Marcel, Glastonbury, Craig A, Stewart, Isobel D, Day, Felix R, Luan, Jian’an, Bowker, Nicholas, Wittemans, Laura B L, Kerrison, Nicola D, Cai, Lina, Lucarelli, Debora M E, Barroso, Inês, McCarthy, Mark I, Scott, Robert A, Saudek, Vladimir, Small, Kerrin S, Wareham, Nicholas J, Semple, Robert K, Perry, John R B, O’Rahilly, Stephen, Lotta, Luca A, Langenberg, Claudia, Savage, David B
Publicado 2021

Rare and common genetic determinants of metabolic individuality and their effects on human health

por Surendran, Praveen, Stewart, Isobel D., Au Yeung, Victoria P. W., Pietzner, Maik, Raffler, Johannes, Wörheide, Maria A., Li, Chen, Smith, Rebecca F., Wittemans, Laura B. L., Bomba, Lorenzo, Menni, Cristina, Zierer, Jonas, Rossi, Niccolò, Sheridan, Patricia A., Watkins, Nicholas A., Mangino, Massimo, Hysi, Pirro G., Di Angelantonio, Emanuele, Falchi, Mario, Spector, Tim D., Soranzo, Nicole, Michelotti, Gregory A., Arlt, Wiebke, Lotta, Luca A., Denaxas, Spiros, Hemingway, Harry, Gamazon, Eric R., Howson, Joanna M. M., Wood, Angela M., Danesh, John, Wareham, Nicholas J., Kastenmüller, Gabi, Fauman, Eric B., Suhre, Karsten, Butterworth, Adam S., Langenberg, Claudia
Publicado 2022

The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium

por Guida, Florence, Tan, Vanessa Y., Corbin, Laura J., Smith-Byrne, Karl, Alcala, Karine, Langenberg, Claudia, Stewart, Isobel D., Butterworth, Adam S., Surendran, Praveen, Achaintre, David, Adamski, Jerzy, Amiano, Pilar, Bergmann, Manuela M., Bull, Caroline J., Dahm, Christina C., Gicquiau, Audrey, Giles, Graham G., Gunter, Marc J., Haller, Toomas, Langhammer, Arnulf, Larose, Tricia L., Ljungberg, Börje, Metspalu, Andres, Milne, Roger L., Muller, David C., Nøst, Therese H., Pettersen Sørgjerd, Elin, Prehn, Cornelia, Riboli, Elio, Rinaldi, Sabina, Rothwell, Joseph A., Scalbert, Augustin, Schmidt, Julie A., Severi, Gianluca, Sieri, Sabina, Vermeulen, Roel, Vincent, Emma E., Waldenberger, Melanie, Timpson, Nicholas J., Johansson, Mattias
Publicado 2021

Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations

por Zheng, Ju-Sheng, Luan, Jian’an, Sofianopoulou, Eleni, Imamura, Fumiaki, Stewart, Isobel D., Day, Felix R., Pietzner, Maik, Wheeler, Eleanor, Lotta, Luca A., Gundersen, Thomas E., Amiano, Pilar, Ardanaz, Eva, Chirlaque, María-Dolores, Fagherazzi, Guy, Franks, Paul W., Kaaks, Rudolf, Laouali, Nasser, Mancini, Francesca Romana, Nilsson, Peter M., Onland-Moret, N. Charlotte, Olsen, Anja, Overvad, Kim, Panico, Salvatore, Palli, Domenico, Ricceri, Fulvio, Rolandsson, Olov, Spijkerman, Annemieke M.W., Sánchez, María-José, Schulze, Matthias B., Sala, Núria, Sieri, Sabina, Tjønneland, Anne, Tumino, Rosario, van der Schouw, Yvonne T., Weiderpass, Elisabete, Riboli, Elio, Danesh, John, Butterworth, Adam S., Sharp, Stephen J., Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J.
Publicado 2021

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis

por Zheng, Ju-Sheng, Luan, Jian’an, Sofianopoulou, Eleni, Sharp, Stephen J., Day, Felix R., Imamura, Fumiaki, Gundersen, Thomas E., Lotta, Luca A., Sluijs, Ivonne, Stewart, Isobel D., Shah, Rupal L., van der Schouw, Yvonne T., Wheeler, Eleanor, Ardanaz, Eva, Boeing, Heiner, Dorronsoro, Miren, Dahm, Christina C., Dimou, Niki, El-Fatouhi, Douae, Franks, Paul W., Fagherazzi, Guy, Grioni, Sara, Huerta, José María, Heath, Alicia K., Hansen, Louise, Jenab, Mazda, Jakszyn, Paula, Kaaks, Rudolf, Kühn, Tilman, Khaw, Kay-Tee, Laouali, Nasser, Masala, Giovanna, Nilsson, Peter M., Overvad, Kim, Olsen, Anja, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Rodríguez-Barranco, Miguel, Sacerdote, Carlotta, Spijkerman, Annemieke M. W., Tong, Tammy Y. N., Tumino, Rosario, Tsilidis, Konstantinos K., Danesh, John, Riboli, Elio, Butterworth, Adam S., Langenberg, Claudia, Forouhi, Nita G., Wareham, Nicholas J.
Publicado 2020

Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study

por Nounu, Aayah, Richmond, Rebecca C., Stewart, Isobel D., Surendran, Praveen, Wareham, Nicholas J., Butterworth, Adam, Weinstein, Stephanie J., Albanes, Demetrius, Baron, John A., Hopper, John L., Figueiredo, Jane C., Newcomb, Polly A., Lindor, Noralane M., Casey, Graham, Platz, Elizabeth A., Marchand, Loïc Le, Ulrich, Cornelia M., Li, Christopher I., van Dujinhoven, Fränzel J. B., Gsur, Andrea, Campbell, Peter T., Moreno, Víctor, Vodicka, Pavel, Vodickova, Ludmila, Amitay, Efrat, Alwers, Elizabeth, Chang-Claude, Jenny, Sakoda, Lori C., Slattery, Martha L., Schoen, Robert E., Gunter, Marc J., Castellví-Bel, Sergi, Kim, Hyeong-Rok, Kweon, Sun-Seog, Chan, Andrew T., Li, Li, Zheng, Wei, Bishop, D. Timothy, Buchanan, Daniel D., Giles, Graham G., Gruber, Stephen B., Rennert, Gad, Stadler, Zsofia K., Harrison, Tabitha A., Lin, Yi, Keku, Temitope O., Woods, Michael O., Schafmayer, Clemens, Van Guelpen, Bethany, Gallinger, Steven, Hampel, Heather, Berndt, Sonja I., Pharoah, Paul D. P., Lindblom, Annika, Wolk, Alicja, Wu, Anna H., White, Emily, Peters, Ulrike, Drew, David A., Scherer, Dominique, Bermejo, Justo Lorenzo, Brenner, Hermann, Hoffmeister, Michael, Williams, Ann C., Relton, Caroline L.
Publicado 2021