Keeping mtDNA in Shape between Generations

por Stewart, James B., Larsson, Nils-Göran
Publicado 2014

No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline

por Hagström, Erik, Freyer, Christoph, Battersby, Brendan J., Stewart, James B., Larsson, Nils-Göran
Publicado 2014

A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency

por Simard, Marie‐Lune, Mourier, Arnaud, Greaves, Laura C, Taylor, Robert W, Stewart, James B
Publicado 2018

High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life

por Glynos, Angelos, Bozhilova, Lyuba V., Frison, Michele, Burr, Stephen, Stewart, James B., Chinnery, Patrick F.
Publicado 2023

The Challenges of Mitochondrial Replacement

por Chinnery, Patrick F., Craven, Lyndsey, Mitalipov, Shoukhrat, Stewart, James B., Herbert, Mary, Turnbull, Douglass M.
Publicado 2014

Ultra-Deep Sequencing of Mouse Mitochondrial DNA: Mutational Patterns and Their Origins

por Ameur, Adam, Stewart, James B., Freyer, Christoph, Hagström, Erik, Ingman, Max, Larsson, Nils-Göran, Gyllensten, Ulf
Publicado 2011

Mitochondrial DNA deletions are associated with non-B DNA conformations

por Damas, Joana, Carneiro, João, Gonçalves, Joana, Stewart, James B., Samuels, David C., Amorim, António, Pereira, Filipe
Publicado 2012

Addressing RNA Integrity to Determine the Impact of Mitochondrial DNA Mutations on Brain Mitochondrial Function with Age

por Wang, Wei, Scheffler, Katja, Esbensen, Ying, Strand, Janne M., Stewart, James B., Bjørås, Magnar, Eide, Lars
Publicado 2014

Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers

por Stewart, James B., Alaei-Mahabadi, Babak, Sabarinathan, Radhakrishnan, Samuelsson, Tore, Gorodkin, Jan, Gustafsson, Claes M., Larsson, Erik
Publicado 2015

Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans

por Baines, Holly L., Stewart, James B., Stamp, Craig, Zupanic, Anze, Kirkwood, Thomas B.L., Larsson, Nils-Göran, Turnbull, Douglass M., Greaves, Laura C.
Publicado 2014

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

por Macao, Bertil, Uhler, Jay P., Siibak, Triinu, Zhu, Xuefeng, Shi, Yonghong, Sheng, Wenwen, Olsson, Monica, Stewart, James B., Gustafsson, Claes M., Falkenberg, Maria
Publicado 2015

Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice

por Kauppila, Johanna H K, Bonekamp, Nina A, Mourier, Arnaud, Isokallio, Marita A, Just, Alexandra, Kauppila, Timo E S, Stewart, James B, Larsson, Nils-Göran
Publicado 2018

The Bicoid Stability Factor Controls Polyadenylation and Expression of Specific Mitochondrial mRNAs in Drosophila melanogaster

por Bratic, Ana, Wredenberg, Anna, Grönke, Sebastian, Stewart, James B., Mourier, Arnaud, Ruzzenente, Benedetta, Kukat, Christian, Wibom, Rolf, Habermann, Bianca, Partridge, Linda, Larsson, Nils-Göran
Publicado 2011

Germline mtDNA mutations aggravate ageing and can impair brain development

por Ross, Jaime M., Stewart, James B., Hagström, Erik, Brené, Stefan, Mourier, Arnaud, Coppotelli, Giuseppe, Freyer, Christoph, Lagouge, Marie, Hoffer, Barry J., Olson, Lars, Larsson, Nils-Göran
Publicado 2013

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

por Bratic, Ana, Kauppila, Timo E. S., Macao, Bertil, Grönke, Sebastian, Siibak, Triinu, Stewart, James B., Baggio, Francesca, Dols, Jacqueline, Partridge, Linda, Falkenberg, Maria, Wredenberg, Anna, Larsson, Nils-Göran
Publicado 2015

A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease

por Kauppila, Johanna H.K., Baines, Holly L., Bratic, Ana, Simard, Marie-Lune, Freyer, Christoph, Mourier, Arnaud, Stamp, Craig, Filograna, Roberta, Larsson, Nils-Göran, Greaves, Laura C., Stewart, James B.
Publicado 2016

Variation in germ line mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

por Freyer, Christoph, Cree, Lynsey M., Mourier, Arnaud, Stewart, James B., Koolmeister, Camilla, Milenkovic, Dusanka, Wai, Timothy, Floros, Vasileios I., Hagström, Erik, Chatzidaki, Emmanouella E., Wiesner, Rudolph J., Samuels, David C, Larsson, Nils-Göran, Chinnery, Patrick F.
Publicado 2012

Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission

por Zhang, Haixin, Esposito, Marco, Pezet, Mikael G., Aryaman, Juvid, Wei, Wei, Klimm, Florian, Calabrese, Claudia, Burr, Stephen P., Macabelli, Carolina H., Viscomi, Carlo, Saitou, Mitinori, Chiaratti, Marcos R., Stewart, James B., Jones, Nick, Chinnery, Patrick F.
Publicado 2021

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria

por Matic, Stanka, Jiang, Min, Nicholls, Thomas J., Uhler, Jay P., Dirksen-Schwanenland, Caren, Polosa, Paola Loguercio, Simard, Marie-Lune, Li, Xinping, Atanassov, Ilian, Rackham, Oliver, Filipovska, Aleksandra, Stewart, James B., Falkenberg, Maria, Larsson, Nils-Göran, Milenkovic, Dusanka
Publicado 2018

Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing

por Basu, Swaraj, Xie, Xie, Uhler, Jay P., Hedberg-Oldfors, Carola, Milenkovic, Dusanka, Baris, Olivier R., Kimoloi, Sammy, Matic, Stanka, Stewart, James B., Larsson, Nils-Göran, Wiesner, Rudolf J., Oldfors, Anders, Gustafsson, Claes M., Falkenberg, Maria, Larsson, Erik
Publicado 2020