Juvenile myelomonocytic leukemia in the molecular era: a clinician’s guide to diagnosis, risk stratification, and treatment

por Wintering, Astrid, Dvorak, Christopher C., Stieglitz, Elliot, Loh, Mignon L.
Publicado 2021

P998: TRETINOIN AND CALCITRIOL ENHANCE TREATMENT REGIMENS FOR JUVENILE MYELOMONOCYTIC LEUKEMIA IN EX VIVO DRUG SENSITIVITY ASSAYS

por Stieglitz, Elliot, Gu, Christine, Dhar, Anukriti, Huebner, Juwita, Ali, Kamran, Lacher, Markus
Publicado 2023

JMML tumor cells disrupt normal hematopoietic stem cells by imposing inflammatory stress through overproduction of IL-1β

por Yan, Yuhan, Dong, Lei, Chen, Chao, Bunting, Kevin D., Li, Qianjin, Stieglitz, Elliot, Loh, Mignon L., Qu, Cheng-Kui
Publicado 2022

Precision cancer monitoring using a novel, fully integrated, microfluidic array partitioning digital PCR platform

por Dueck, Megan E., Lin, Robert, Zayac, Andrew, Gallagher, Steve, Chao, Alexander K., Jiang, Lingxia, Datwani, Sammy S., Hung, Paul, Stieglitz, Elliot
Publicado 2019

Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples

por Behnert, Astrid, Meyer, Julia, Parsa, Jahan-Yar, Hechmer, Aaron, Loh, Mignon L., Olshen, Adam, de Smith, Adam J., Stieglitz, Elliot
Publicado 2021

P985: CLL-1 IS AN ADOPTIVE IMMUNOTHERAPY TARGET IN JUVENILE MYELOMONOCYTIC LEUKEMIA

por Huebner, Juwita, Xirenayi, Sherin, Rivera, Jose, Patiño Escobar, Bonell, Lee, Alex G, Mandal, Kamal, Diaz-Flores, Ernesto, Wiita, Arun, Stieglitz, Elliot
Publicado 2023

Detection of a GLIS3 fusion in an infant with AML refractory to chemotherapy

por Smith, Stephen M., Lee, Alex G., Tong, Schuyler, Leung, Stanley G., Hongo, Henry, Rivera, Jose M., Sweet-Cordero, E. Alejandro, Michlitsch, Jennifer, Stieglitz, Elliot
Publicado 2022

Clinical parameter-based prediction of DNA methylation classification generates a prediction model of prognosis in patients with juvenile myelomonocytic leukemia

por Imaizumi, Takahiro, Meyer, Julia, Wakamatsu, Manabu, Kitazawa, Hironobu, Murakami, Norihiro, Okuno, Yusuke, Yoshida, Taro, Sajiki, Daichi, Hama, Asahito, Kojima, Seiji, Takahashi, Yoshiyuki, Loh, Mignon, Stieglitz, Elliot, Muramatsu, Hideki
Publicado 2022

Genome-wide DNA methylation is predictive of outcome in juvenile myelomonocytic leukemia

por Stieglitz, Elliot, Mazor, Tali, Olshen, Adam B., Geng, Huimin, Gelston, Laura C., Akutagawa, Jon, Lipka, Daniel B., Plass, Christoph, Flotho, Christian, Chehab, Farid F., Braun, Benjamin S., Costello, Joseph F., Loh, Mignon L.
Publicado 2017

P561: REVUMENIB IN PATIENTS WITH ACUTE LEUKEMIAS: COMPASSIONATE USE PROGRAM EXPERIENCE

por Rubnitz, Jeffrey, C. Issa, Ghayas, M. Stein, Eytan, Shukla, Neerav, Stock, Wendy, Žučenka, Andrius, Khazal, Sajad, Khera, Nandita, Stieglitz, Elliot, Rubinstein, Jeremy, Rosen, Galit, Ghiraldi, Rachel, Van Nguyen, Huy, Mcneer, Nicole, Zwaan, C. Michel
Publicado 2023

Tretinoin Enhances the Effects of Chemotherapy in Juvenile Myelomonocytic Leukemia Using an Ex Vivo Drug Sensitivity Assay

por Stieglitz, Elliot, Gu, Christine J., Richardson, Michelle, Kita, Ryosuke, Santaguida, Marianne T., Ali, Kamran A., Strachan, Debbie C., Dhar, Anukriti, Yam, George, Anderson, Wade, Anderson, Erica, Hübner, Juwita, Tasian, Sarah K., Loh, Mignon L., Lacher, Markus D.
Publicado 2023

Inhibition of BTK and PI3Kδ impairs the development of human JMML stem and progenitor cells

por Ramdas, Baskar, Yuen, Lisa Deng, Palam, Lakshmi Reddy, Patel, Roshini, Pasupuleti, Santhosh Kumar, Jideonwo, Victoria, Zhang, Ji, Maguire, Callista, Wong, Eric, Kanumuri, Rahul, Zhang, Chujing, Sandusky, George, Chan, Rebecca J., Zhang, Chi, Stieglitz, Elliot, Haneline, Laura, Kapur, Reuben
Publicado 2022

Framework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies

por Temple, William C, Nix, Matthew A, Naik, Akul, Izgutdina, Adila, Huang, Benjamin J, Wicaksono, Gianina, Phojanakong, Paul, Serrano, Juan Antonio Camara, Young, Elizabeth P, Ramos, Emilio, Salangsang, Fernando, Steri, Veronica, Xirenayi, Simayijiang, Hermiston, Michelle, Logan, Aaron C, Stieglitz, Elliot, Wiita, Arun P
Publicado 2023

Simple and robust methylation test for risk stratification of patients with juvenile myelomonocytic leukemia

por Kitazawa, Hironobu, Okuno, Yusuke, Muramatsu, Hideki, Aoki, Kosuke, Murakami, Norihiro, Wakamatsu, Manabu, Suzuki, Kyogo, Narita, Kotaro, Kataoka, Shinsuke, Ichikawa, Daisuke, Hamada, Motoharu, Taniguchi, Rieko, Kawashima, Nozomu, Nishikawa, Eri, Narita, Atsushi, Nishio, Nobuhiro, Hama, Asahito, Loh, Mignon L., Stieglitz, Elliot, Kojima, Seiji, Takahashi, Yoshiyuki
Publicado 2021

Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML

por Popescu, Bogdan, Stahlhut, Carlos, Tarver, Theodore C., Wishner, Sydney, Lee, Bianca J., Peretz, Cheryl A.C., Luck, Cuyler, Phojanakong, Paul, Camara Serrano, Juan Antonio, Hongo, Henry, Rivera, Jose M., Xirenayi, Simayijiang, Chukinas, John A., Steri, Veronica, Tasian, Sarah K., Stieglitz, Elliot, Smith, Catherine C.
Publicado 2023

Low Toxicity and Favorable Overall Survival in Relapsed/Refractory B-ALL following CAR T cells and CD34-selected T Cell Depleted Allogeneic Hematopoietic Cell Transplant.

por Fabrizio, Vanessa A., Kernan, Nancy A., Boulad, Farid, Cancio, Maria, Allen, Jennifer, Higman, Meghan, Margossian, Steven P., Mauguen, Audrey, Prockop, Susan, Scaradavou, Andromachi, Shah, Niketa, Spitzer, Barbara, Stieglitz, Elliot, Yeager, Nicholas, O’Reilly, Richard J., Brentjens, Renier J., Boelens, Jaap Jan, Curran, Kevin J.
Publicado 2020

Complete Response to PD-1 Inhibition in an Adolescent With Relapsed Clear Cell Adenocarcinoma of the Cervix Predicted by Neoepitope Burden and APOBEC Signature

por Levinson, Anya, Lee, Alex G., Martell, Henry J., Breese, Marcus R., Zaloudek, Charles, Van Ziffle, Jessica, Laguna, Benjamin, Leung, Stanley G., Chen, M. Dwight, Chen, Lee-may, Pfeil, Jacob, Ladwig, Nicholas R., Shah, Avanthi Tayi, Behroozfard, Inge, Rao, Arjun Arkal, Salama, Sofie R., Sweet-Cordero, E. Alejandro, Stieglitz, Elliot
Publicado 2020

Successful treatment and integrated genomic analysis of an infant with FIP1L1-RARA fusion–associated myeloid neoplasm

por Miltiadous, Oriana, Petrova-Drus, Kseniya, Kaicker, Shipra, Mathew, Susan, Kluk, Michael, Geyer, Julia T., Rodriguez-Sanchez, Irene, Bouvier, Nancy, Inghirami, Giorgio, Stieglitz, Elliot, Khedoudja, Nafa, Benayed, Ryma, Richardson, Michelle, Anderson, Wade, Benhamida, Jamal, You, Daoqi, Londono, Dory, Kung, Andrew L., Prockop, Susan E., Roshal, Mikhail, Zhang, Yanming, Shukla, Neerav
Publicado 2022

Molecular and phenotypic diversity of CBLmutated juvenile myelomonocytic leukemia

por Hecht, Anna, Meyer, Julia A., Behnert, Astrid, Wong, Eric, Chehab, Farid, Olshen, Adam, Hechmer, Aaron, Aftandilian, Catherine, Bhat, Rukhmi, Won Choi, Sung, Chonat, Satheesh, Farrar, Jason E., Fluchel, Mark, Frangoul, Haydar, Han, Jennifer H., Kolb, Edward A., Kuo, Dennis J., MacMillan, Margaret L., Maese, Luke, Maloney, Kelly W., Narendran, Aru, Oshrine, Benjamin, Schultz, Kirk R., Sulis, Maria L., Van Mater, David, Tasian, Sarah K., Hofmann, Wolf-Karsten, Loh, Mignon L., Stieglitz, Elliot
Publicado 2020

Structural surfaceomics reveals an AML-specific conformation of integrin β(2) as a CAR T cellular therapy target

por Mandal, Kamal, Wicaksono, Gianina, Yu, Clinton, Adams, Jarrett J., Hoopmann, Michael R., Temple, William C., Izgutdina, Adila, Escobar, Bonell Patiño, Gorelik, Maryna, Ihling, Christian H., Nix, Matthew A., Naik, Akul, Xie, William H., Hübner, Juwita, Rollins, Lisa A., Reid, Sandy M., Ramos, Emilio, Kasap, Corynn, Steri, Veronica, Serrano, Juan Antonio Camara, Salangsang, Fernando, Phojanakong, Paul, McMillan, Melanie, Gavallos, Victor, Leavitt, Andrew D., Logan, Aaron C., Rooney, Cliona M., Eyquem, Justin, Sinz, Andrea, Huang, Benjamin J., Stieglitz, Elliot, Smith, Catherine C., Moritz, Robert L., Sidhu, Sachdev S., Huang, Lan, Wiita, Arun P.
Publicado 2023