(Epi)genomic heterogeneity of pancreatic islet function and failure in type 2 diabetes

por Lawlor, Nathan, Stitzel, Michael L.
Publicado 2019

Computational inference of H3K4me3 and H3K27ac domain length

por Zubek, Julian, Stitzel, Michael L., Ucar, Duygu, Plewczynski, Dariusz M.
Publicado 2016

Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts

por Lawlor, Nathan, Youn, Ahrim, Kursawe, Romy, Ucar, Duygu, Stitzel, Michael L.
Publicado 2017

A neural network based model effectively predicts enhancers from clinical ATAC-seq samples

por Thibodeau, Asa, Uyar, Asli, Khetan, Shubham, Stitzel, Michael L., Ucar, Duygu
Publicado 2018

BiFET: sequencing Bias-free transcription factor Footprint Enrichment Test

por Youn, Ahrim, Marquez, Eladio J, Lawlor, Nathan, Stitzel, Michael L, Ucar, Duygu
Publicado 2019

CoRE-ATAC: A deep learning model for the functional classification of regulatory elements from single cell and bulk ATAC-seq data

por Thibodeau, Asa, Khetan, Shubham, Eroglu, Alper, Tewhey, Ryan, Stitzel, Michael L., Ucar, Duygu
Publicado 2021

Identification of Suppressors of mbk-2/DYRK by Whole-Genome Sequencing

por Wang, Yuemeng, Wang, Jennifer T., Rasoloson, Dominique, Stitzel, Michael L., O’ Connell, Kevin F., Smith, Harold E., Seydoux, Geraldine
Publicado 2013

Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes

por Lawlor, Nathan, George, Joshy, Bolisetty, Mohan, Kursawe, Romy, Sun, Lili, Sivakamasundari, V., Kycia, Ina, Robson, Paul, Stitzel, Michael L.
Publicado 2017

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

por Khetan, Shubham, Kales, Susan, Kursawe, Romy, Jillette, Alexandria, Ulirsch, Jacob C., Reilly, Steven K., Ucar, Duygu, Tewhey, Ryan, Stitzel, Michael L.
Publicado 2021

QuIN: A Web Server for Querying and Visualizing Chromatin Interaction Networks

por Thibodeau, Asa, Márquez, Eladio J., Luo, Oscar, Ruan, Yijun, Menghi, Francesca, Shin, Dong-Guk, Stitzel, Michael L., Vera-Licona, Paola, Ucar, Duygu
Publicado 2016

Single Cell Analysis of Blood Mononuclear Cells Stimulated Through Either LPS or Anti-CD3 and Anti-CD28

por Lawlor, Nathan, Nehar-Belaid, Djamel, Grassmann, Jessica D.S., Stoeckius, Marlon, Smibert, Peter, Stitzel, Michael L., Pascual, Virginia, Banchereau, Jacques, Williams, Adam, Ucar, Duygu
Publicado 2021

Tet2 Controls the Responses of β cells to Inflammation in Autoimmune Diabetes

por Rui, Jinxiu, Deng, Songyan, Perdigoto, Ana Luisa, Ponath, Gerald, Kursawe, Romy, Lawlor, Nathan, Sumida, Tomokazu, Levine-Ritterman, Maya, Stitzel, Michael L., Pitt, David, Lu, Jun, Herold, Kevan C.
Publicado 2021

The chromatin accessibility signature of human immune aging stems from CD8(+) T cells

por Ucar, Duygu, Márquez, Eladio J., Chung, Cheng-Han, Marches, Radu, Rossi, Robert J., Uyar, Asli, Wu, Te-Chia, George, Joshy, Stitzel, Michael L., Palucka, A. Karolina, Kuchel, George A., Banchereau, Jacques
Publicado 2017

A Transcription Start Site Map in Human Pancreatic Islets Reveals Functional Regulatory Signatures

por Varshney, Arushi, Kyono, Yasuhiro, Elangovan, Venkateswaran Ramamoorthi, Wang, Collin, Erdos, Michael R., Narisu, Narisu, Albanus, Ricardo D’Oliveira, Orchard, Peter, Stitzel, Michael L., Collins, Francis S., Kitzman, Jacob O., Parker, Stephen C.J.
Publicado 2021

AMULET: a novel read count-based method for effective multiplet detection from single nucleus ATAC-seq data

por Thibodeau, Asa, Eroglu, Alper, McGinnis, Christopher S., Lawlor, Nathan, Nehar-Belaid, Djamel, Kursawe, Romy, Marches, Radu, Conrad, Daniel N., Kuchel, George A., Gartner, Zev J., Banchereau, Jacques, Stitzel, Michael L., Cicek, A. Ercument, Ucar, Duygu
Publicado 2021

Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits

por Hudaiberdiev, Sanjarbek, Taylor, D. Leland, Song, Wei, Narisu, Narisu, Bhuiyan, Redwan M., Taylor, Henry J., Tang, Xuming, Yan, Tingfen, Swift, Amy J., Bonnycastle, Lori L., Consortium, DIAMANTE, Chen, Shuibing, Stitzel, Michael L., Erdos, Michael R., Ovcharenko, Ivan, Collins, Francis S.
Publicado 2023

Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

por Bonnycastle, Lori L., Chines, Peter S., Hara, Takashi, Huyghe, Jeroen R., Swift, Amy J., Heikinheimo, Pirkko, Mahadevan, Jana, Peltonen, Sirkku, Huopio, Hanna, Nuutila, Pirjo, Narisu, Narisu, Goldfeder, Rachel L., Stitzel, Michael L., Lu, Simin, Boehnke, Michael, Urano, Fumihiko, Collins, Francis S., Laakso, Markku
Publicado 2013

Variation in histone configurations correlates with gene expression across nine inbred strains of mice

por Tyler, Anna L., Spruce, Catrina, Kursawe, Romy, Haber, Annat, Ball, Robyn L., Pitman, Wendy A., Fine, Alexander D., Raghupathy, Narayanan, Walker, Michael, Philip, Vivek M., Baker, Christopher L., Mahoney, J. Matthew, Churchill, Gary A., Trowbridge, Jennifer J., Stitzel, Michael L., Paigen, Kenneth, Petkov, Petko M., Carter, Gregory W.
Publicado 2023

Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and Function

por Lawlor, Nathan, Márquez, Eladio J., Orchard, Peter, Narisu, Narisu, Shamim, Muhammad Saad, Thibodeau, Asa, Varshney, Arushi, Kursawe, Romy, Erdos, Michael R., Kanke, Matt, Gu, Huiya, Pak, Evgenia, Dutra, Amalia, Russell, Sheikh, Li, Xingwang, Piecuch, Emaly, Luo, Oscar, Chines, Peter S., Fuchbserger, Christian, Sethupathy, Praveen, Aiden, Aviva Presser, Ruan, Yijun, Aiden, Erez Lieberman, Collins, Francis S., Ucar, Duygu, Parker, Stephen C.J., Stitzel, Michael L.
Publicado 2019

Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D

por Viñuela, Ana, Varshney, Arushi, van de Bunt, Martijn, Prasad, Rashmi B., Asplund, Olof, Bennett, Amanda, Boehnke, Michael, Brown, Andrew A., Erdos, Michael R., Fadista, João, Hansson, Ola, Hatem, Gad, Howald, Cédric, Iyengar, Apoorva K., Johnson, Paul, Krus, Ulrika, MacDonald, Patrick E., Mahajan, Anubha, Manning Fox, Jocelyn E., Narisu, Narisu, Nylander, Vibe, Orchard, Peter, Oskolkov, Nikolay, Panousis, Nikolaos I., Payne, Anthony, Stitzel, Michael L., Vadlamudi, Swarooparani, Welch, Ryan, Collins, Francis S., Mohlke, Karen L., Gloyn, Anna L., Scott, Laura J., Dermitzakis, Emmanouil T., Groop, Leif, Parker, Stephen C. J., McCarthy, Mark I.
Publicado 2020