Effect of a toggle switch mutation in TM6 of the human adenosine A(3) receptor on Gi protein-dependent signalling and Gi-independent receptor internalization

por Stoddart, Leigh A, Kellam, Barrie, Briddon, Stephen J, Hill, Stephen J
Publicado 2014

Use of a new proximity assay (NanoBRET) to investigate the ligand‐binding characteristics of three fluorescent ligands to the human β (1)‐adrenoceptor expressed in HEK‐293 cells...

por Soave, Mark, Stoddart, Leigh A., Brown, Alastair, Woolard, Jeanette, Hill, Stephen J.
Publicado 2016

Binding kinetics of ligands acting at GPCRs

por Sykes, David A., Stoddart, Leigh A., Kilpatrick, Laura E., Hill, Stephen J.
Publicado 2019

Allosteric interactions across native adenosine-A(3) receptor homodimers: quantification using single-cell ligand-binding kinetics

por May, Lauren T., Bridge, Lloyd J., Stoddart, Leigh A., Briddon, Stephen J., Hill, Stephen J.
Publicado 2011

Fluorescence‐ and bioluminescence‐based approaches to study GPCR ligand binding

por Stoddart, Leigh A, White, Carl W, Nguyen, Kim, Hill, Stephen J, Pfleger, Kevin D G
Publicado 2015

A Non-imaging High Throughput Approach to Chemical Library Screening at the Unmodified Adenosine-A(3) Receptor in Living Cells

por Arruda, Maria Augusta, Stoddart, Leigh A., Gherbi, Karolina, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado 2017

Efficient G protein coupling is not required for agonist‐mediated internalization and membrane reorganization of the adenosine A(3) receptor

por Stoddart, Leigh A., Kilpatrick, Laura E., Corriden, Ross, Kellam, Barrie, Briddon, Stephen J., Hill, Stephen J.
Publicado 2021

Fragment Screening at Adenosine-A(3) Receptors in Living Cells Using a Fluorescence-Based Binding Assay

por Stoddart, Leigh A., Vernall, Andrea J., Denman, Jessica L., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado 2012

Detection of genome‐edited and endogenously expressed G protein‐coupled receptors

por Soave, Mark, Stoddart, Leigh A., White, Carl W., Kilpatrick, Laura E., Goulding, Joëlle, Briddon, Stephen J., Hill, Stephen J.
Publicado 2021

A live cell NanoBRET binding assay allows the study of ligand-binding kinetics to the adenosine A(3) receptor

por Bouzo-Lorenzo, Monica, Stoddart, Leigh A., Xia, Lizi, IJzerman, Adriaan P., Heitman, Laura H., Briddon, Stephen J., Hill, Stephen J.
Publicado 2019

Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y(2) Receptor Based on AR-C118925

por Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard J., Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.
Publicado 2018

Correction to Synthesis and Evaluation of the First Fluorescent Antagonists of the Human P2Y(2) Receptor Based on AR-C118925

por Conroy, Sean, Kindon, Nicholas D., Glenn, Jacqueline, Stoddart, Leigh A., Lewis, Richard J., Hill, Stephen J., Kellam, Barrie, Stocks, Michael J.
Publicado 2018

Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor

por Dekkers, Sebastian, Caspar, Birgit, Goulding, Joëlle, Kindon, Nicholas D., Kilpatrick, Laura E., Stoddart, Leigh A., Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J., Stocks, Michael J.
Publicado 2023

Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H(1) Receptor

por Kok, Zhi Yuan, Stoddart, Leigh A., Mistry, Sarah J., Mocking, Tamara A. M., Vischer, Henry F., Leurs, Rob, Hill, Stephen J., Mistry, Shailesh N., Kellam, Barrie
Publicado 2022

Application of BRET to monitor ligand binding to GPCRs

por Stoddart, Leigh A, Johnstone, Elizabeth K M, Wheal, Amanda J, Goulding, Joëlle, Robers, Matthew B, Machleidt, Thomas, Wood, Keith V, Hill, Stephen J, Pfleger, Kevin D G
Publicado 2015

Ligand-directed covalent labelling of a GPCR with a fluorescent tag in live cells

por Stoddart, Leigh A., Kindon, Nicholas D., Otun, Omolade, Harwood, Clare R., Patera, Foteini, Veprintsev, Dmitry B., Woolard, Jeanette, Briddon, Stephen J., Franks, Hester A., Hill, Stephen J., Kellam, Barrie
Publicado 2020

Development of novel fluorescent histamine H(1)-receptor antagonists to study ligand-binding kinetics in living cells

por Stoddart, Leigh A., Vernall, Andrea J., Bouzo-Lorenzo, Monica, Bosma, Reggie, Kooistra, Albert J., de Graaf, Chris, Vischer, Henry F., Leurs, Rob, Briddon, Stephen J., Kellam, Barrie, Hill, Stephen J.
Publicado 2018

Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor

por Bosma, Reggie, Stoddart, Leigh A., Georgi, Victoria, Bouzo-Lorenzo, Monica, Bushby, Nick, Inkoom, Loretta, Waring, Michael J., Briddon, Stephen J., Vischer, Henry F., Sheppard, Robert J., Fernández-Montalván, Amaury, Hill, Stephen J., Leurs, Rob
Publicado 2019

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors

por Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria P, Alexander, Wayne, Al-hosaini, Khaled, Bäck, Magnus, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel JM, Blaho, Victoria, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P, Catt, Kevin J, Ceruti, Stefania, Chazot, Paul, Chiang, Nan, Chun, Jerold, Cianciulli, Antonia, Clapp, Lucie H, Couture, Réjean, Csaba, Zsolt, Dent, Gordon, Singh, Khuraijam Dhanachandra, Douglas, Steven D, Dournaud, Pascal, Eguchi, Satoru, Escher, Emanuel, Filardo, Edward, Fong, Tung M, Fumagalli, Marta, Gainetdinov, Raul R, de Gasparo, Marc, Gershengorn, Marvin, Gobeil, Fernand, Goodfriend, Theodore L, Goudet, Cyril, Gregory, Karen J, Gundlach, Andrew L, Hamann, Jörg, Hanson, Julien, Hauger, Richard L, Hay, Debbie, Heinemann, Akos, Hollenberg, Morley D, Holliday, Nicholas D, Horiuchi, Mastgugu, Hoyer, Daniel, Hunyady, László, Husain, Ahsan, Ijzerman, Adriaan P, Inagami, Tadashi, Jacobson, Kenneth A, Jensen, Robert T, Jockers, Ralf, Jonnalagadda, Deepa, Karnik, Sadashiva, Kaupmann, Klemens, Kemp, Jacqueline, Kennedy, Charles, Kihara, Yasuyuki, Kozielewicz, Paweł, Kreienkamp, Hans‐Jürgen, Kukkonen, Jyrki P, Langenhan, Tobias, Leach, Katie, Lecca, Davide, Lee, John D, Leeman, Susan E, Leprince, Jérôme, Lolait, Stephen J, Lupp, Amelie, Macrae, Robyn, Maguire, Janet, Mazella, Jean, McArdle, Craig A, Melmed, Shlomo, Michel, Martin C, Miller, Laurence, Mitolo, Vincenzo, Mouillac, Bernard, Murphy, Philip M, Nahon, Jean‐Louis, Norel, Xavier, Nyimanu, Duuamene, O'Carroll, Anne‐Marie, Offermanns, Stefan, Panaro, Maria A, Pertwee, Roger G, Pin, Jean‐Philippe, Prossnitz, Eric, Ramachandran, Rithwik, Reinscheid, Rainer K, Rondard, Philippe, Rovati, G Enrico, Ruzza, Chiara, Sanger, Gareth, Schöneberg, Torsten, Schulte, Gunnar, Schulz, Stefan, Segaloff, Deborah L, Serhan, Charles N, Stoddart, Leigh A, Sugimoto, Yukihiko, Summers, Roger, Tan, Valerie, Thomas, Walter, Timmermans, Pieter BMWM, Tirupula, Kalyan, Tulipano, Giovanni, Unal, Hamiyet, Unger, Thomas, Vanderheyden, Patrick, Vaudry, David, Vaudry, Hubert, Vilardaga, Jean‐Pierre, Walker, Christopher S, Ward, Donald T, Wester, Hans‐Jürgen, Willars, Gary B, Williams, Tom Lloyd, Woodruff, Trent M, Yao, Chengcan
Publicado 2019