Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

por Luong, Xuan G., Stevens, Sarah K., Jekle, Andreas, Lin, Tse-I, Gupta, Kusum, Misner, Dinah, Chanda, Sushmita, Mukherjee, Sucheta, Williams, Caroline, Stoycheva, Antitsa, Blatt, Lawrence M., Beigelman, Leonid N., Symons, Julian A., Raboisson, Pierre, McGowan, David, Vandyck, Koen, Deval, Jerome
Publicado 2020

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models

por Jekle, Andreas, Thatikonda, Santosh Kumar, Jaisinghani, Ruchika, Ren, Suping, Kinkade, April, Stevens, Sarah K., Stoycheva, Antitsa, Rajwanshi, Vivek K., Williams, Caroline, Deval, Jerome, Mukherjee, Sucheta, Zhang, Qingling, Chanda, Sushmita, Smith, David B., Blatt, Lawrence M., Symons, Julian A., Gonzalvez, Francois, Beigelman, Leonid
Publicado 2023

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

por Vandyck, Koen, Abdelnabi, Rana, Gupta, Kusum, Jochmans, Dirk, Jekle, Andreas, Deval, Jerome, Misner, Dinah, Bardiot, Dorothée, Foo, Caroline S., Liu, Cheng, Ren, Suping, Beigelman, Leonid, Blatt, Lawrence M., Boland, Sandro, Vangeel, Laura, Dejonghe, Steven, Chaltin, Patrick, Marchand, Arnaud, Serebryany, Vladimir, Stoycheva, Antitsa, Chanda, Sushmita, Symons, Julian A., Raboisson, Pierre, Neyts, Johan
Publicado 2021

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

por Deval, Jerome, Hong, Jin, Wang, Guangyi, Taylor, Josh, Smith, Lucas K., Fung, Amy, Stevens, Sarah K., Liu, Hong, Jin, Zhinan, Dyatkina, Natalia, Prhavc, Marija, Stoycheva, Antitsa D., Serebryany, Vladimir, Liu, Jyanwei, Smith, David B., Tam, Yuen, Zhang, Qingling, Moore, Martin L., Fearns, Rachel, Chanda, Sushmita M., Blatt, Lawrence M., Symons, Julian A., Beigelman, Leo
Publicado 2015

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

por Jochmans, Dirk, Liu, Cheng, Donckers, Kim, Stoycheva, Antitsa, Boland, Sandro, Stevens, Sarah K., De Vita, Chloe, Vanmechelen, Bert, Maes, Piet, Trüeb, Bettina, Ebert, Nadine, Thiel, Volker, De Jonghe, Steven, Vangeel, Laura, Bardiot, Dorothée, Jekle, Andreas, Blatt, Lawrence M., Beigelman, Leonid, Symons, Julian A., Raboisson, Pierre, Chaltin, Patrick, Marchand, Arnaud, Neyts, Johan, Deval, Jerome, Vandyck, Koen
Publicado 2023