Controlling fertilization and cAMP signaling in sperm by optogenetics

por Jansen, Vera, Alvarez, Luis, Balbach, Melanie, Strünker, Timo, Hegemann, Peter, Kaupp, U Benjamin, Wachten, Dagmar
Publicado 2015

The solute carrier SLC9C1 is a Na(+)/H(+)-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

por Windler, F., Bönigk, W., Körschen, H. G., Grahn, E., Strünker, T., Seifert, R., Kaupp, U. B.
Publicado 2018

Author Correction: The solute carrier SLC9C1 is a Na(+)/H(+)-exchanger gated by an S4-type voltage-sensor and cyclic-nucleotide binding

por Windler, F., Bönigk, W., Körschen, H. G., Grahn, E., Strünker, T., Seifert, R., Kaupp, U. B.
Publicado 2020

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes

por Kierzek, Michelina, Deal, Parker E, Miller, Evan W, Mukherjee, Shatanik, Wachten, Dagmar, Baumann, Arnd, Kaupp, U Benjamin, Strünker, Timo, Brenker, Christoph
Publicado 2021

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains

por Raju, Diana N., Hansen, Jan N., Rassmann, Sebastian, Stüven, Birthe, Jikeli, Jan F., Strünker, Timo, Körschen, Heinz G., Möglich, Andreas, Wachten, Dagmar
Publicado 2019

A novel biosensor to study cAMP dynamics in cilia and flagella

por Mukherjee, Shatanik, Jansen, Vera, Jikeli, Jan F, Hamzeh, Hussein, Alvarez, Luis, Dombrowski, Marco, Balbach, Melanie, Strünker, Timo, Seifert, Reinhard, Kaupp, U Benjamin, Wachten, Dagmar
Publicado 2016

The antidepressant Sertraline inhibits CatSper Ca(2+) channels in human sperm

por Rahban, Rita, Rehfeld, Anders, Schiffer, Christian, Brenker, Christoph, Egeberg Palme, Dorte Louise, Wang, Tao, Lorenz, Johannes, Almstrup, Kristian, Skakkebaek, Niels E, Strünker, Timo, Nef, Serge
Publicado 2021

The Ca(2+)-activated K(+) current of human sperm is mediated by Slo3

por Brenker, Christoph, Zhou, Yu, Müller, Astrid, Echeverry, Fabio Andres, Trötschel, Christian, Poetsch, Ansgar, Xia, Xiao-Ming, Bönigk, Wolfgang, Lingle, Christopher J, Kaupp, U Benjamin, Strünker, Timo
Publicado 2014

Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system

por Aprea, Isabella, Nöthe-Menchen, Tabea, Dougherty, Gerard W, Raidt, Johanna, Loges, Niki T, Kaiser, Thomas, Wallmeier, Julia, Olbrich, Heike, Strünker, Timo, Kliesch, Sabine, Pennekamp, Petra, Omran, Heymut
Publicado 2021

Pathogenic gene variants in CCDC39, CCDC40, RSPH1, RSPH9, HYDIN, and SPEF2 cause defects of sperm flagella composition and male infertility

por Aprea, I., Wilken, A., Krallmann, C., Nöthe-Menchen, T., Olbrich, H., Loges, N. T., Dougherty, G. W., Bracht, D., Brenker, C., Kliesch, S., Strünker, T., Tüttelmann, F., Raidt, J., Omran, H.
Publicado 2023

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives

por Ritter, Nadine, Disse, Paul, Aymanns, Isabel, Mücher, Lena, Schreiber, Julian A., Brenker, Christoph, Strünker, Timo, Schepmann, Dirk, Budde, Thomas, Strutz-Seebohm, Nathalie, Ametamey, Simon M., Wünsch, Bernhard, Seebohm, Guiscard
Publicado 2023

Rotational motion and rheotaxis of human sperm do not require functional CatSper channels and transmembrane Ca(2+) signaling

por Schiffer, Christian, Rieger, Steffen, Brenker, Christoph, Young, Samuel, Hamzeh, Hussein, Wachten, Dagmar, Tüttelmann, Frank, Röpke, Albrecht, Kaupp, U Benjamin, Wang, Tao, Wagner, Alice, Krallmann, Claudia, Kliesch, Sabine, Fallnich, Carsten, Strünker, Timo
Publicado 2020

Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation

por Trötschel, Christian, Hamzeh, Hussein, Alvarez, Luis, Pascal, René, Lavryk, Fedir, Bönigk, Wolfgang, Körschen, Heinz G, Müller, Astrid, Poetsch, Ansgar, Rennhack, Andreas, Gui, Long, Nicastro, Daniela, Strünker, Timo, Seifert, Reinhard, Kaupp, U Benjamin
Publicado 2019

Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm

por Balbach, Melanie, Hamzeh, Hussein, Jikeli, Jan F., Brenker, Christoph, Schiffer, Christian, Hansen, Jan N., Neugebauer, Pia, Trötschel, Christian, Jovine, Luca, Han, Ling, Florman, Harvey M., Kaupp, U. Benjamin, Strünker, Timo, Wachten, Dagmar
Publicado 2020

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn(2+) on CatSper Ca(2+) Channels in Human Sperm

por Jeschke, Janice K., Biagioni, Cristina, Schierling, Tobias, Wagner, Isabel Viola, Börgel, Frederik, Schepmann, Dirk, Schüring, Andreas, Kulle, Alexandra E., Holterhus, Paul Martin, von Wolff, Michael, Wünsch, Bernhard, Nordhoff, Verena, Strünker, Timo, Brenker, Christoph
Publicado 2021

CRIS—A Novel cAMP-Binding Protein Controlling Spermiogenesis and the Development of Flagellar Bending

por Krähling, Anke Miriam, Alvarez, Luis, Debowski, Katharina, Van, Qui, Gunkel, Monika, Irsen, Stephan, Al-Amoudi, Ashraf, Strünker, Timo, Kremmer, Elisabeth, Krause, Eberhard, Voigt, Ingo, Wörtge, Simone, Waisman, Ari, Weyand, Ingo, Seifert, Reinhard, Kaupp, Ulrich Benjamin, Wachten, Dagmar
Publicado 2013

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis

por Amedonu, Elsie, Brenker, Christoph, Barman, Sumanta, Schreiber, Julian A., Becker, Sebastian, Peischard, Stefan, Strutz-Seebohm, Nathalie, Strippel, Christine, Dik, Andre, Hartung, Hans-Peter, Budde, Thomas, Wiendl, Heinz, Strünker, Timo, Wünsch, Bernhard, Goebels, Norbert, Meuth, Sven G., Seebohm, Guiscard, Melzer, Nico
Publicado 2019

High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

por Pichlo, Magdalena, Bungert-Plümke, Stefanie, Weyand, Ingo, Seifert, Reinhard, Bönigk, Wolfgang, Strünker, Timo, Kashikar, Nachiket Dilip, Goodwin, Normann, Müller, Astrid, Körschen, Heinz G., Collienne, Ursel, Pelzer, Patric, Van, Qui, Enderlein, Jörg, Klemm, Clementine, Krause, Eberhard, Trötschel, Christian, Poetsch, Ansgar, Kremmer, Elisabeth, Kaupp, U. Benjamin
Publicado 2014

High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor

por Pichlo, Magdalena, Bungert-Plümke, Stefanie, Weyand, Ingo, Seifert, Reinhard, Bönigk, Wolfgang, Strünker, Timo, Kashikar, Nachiket Dilip, Goodwin, Normann, Müller, Astrid, Körschen, Heinz G., Collienne, Ursel, Pelzer, Patric, Van, Qui, Enderlein, Jörg, Klemm, Clementine, Krause, Eberhard, Trötschel, Christian, Poetsch, Ansgar, Kremmer, Elisabeth, Kaupp, U. Benjamin
Publicado 2014

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

por Dougherty, Gerard W., Mizuno, Katsutoshi, Nöthe-Menchen, Tabea, Ikawa, Yayoi, Boldt, Karsten, Ta-Shma, Asaf, Aprea, Isabella, Minegishi, Katsura, Pang, Yuan-Ping, Pennekamp, Petra, Loges, Niki T., Raidt, Johanna, Hjeij, Rim, Wallmeier, Julia, Mussaffi, Huda, Perles, Zeev, Elpeleg, Orly, Rabert, Franziska, Shiratori, Hidetaka, Letteboer, Stef J., Horn, Nicola, Young, Samuel, Strünker, Timo, Stumme, Friederike, Werner, Claudius, Olbrich, Heike, Takaoka, Katsuyoshi, Ide, Takahiro, Twan, Wang Kyaw, Biebach, Luisa, Große-Onnebrink, Jörg, Klinkenbusch, Judith A., Praveen, Kavita, Bracht, Diana C., Höben, Inga M., Junger, Katrin, Gützlaff, Jana, Cindrić, Sandra, Aviram, Micha, Kaiser, Thomas, Memari, Yasin, Dzeja, Petras P., Dworniczak, Bernd, Ueffing, Marius, Roepman, Ronald, Bartscherer, Kerstin, Katsanis, Nicholas, Davis, Erica E., Amirav, Israel, Hamada, Hiroshi, Omran, Heymut
Publicado 2020