An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers

por Thomas, Simon, Straathof, Karin, Himoudi, Nourredine, Anderson, John, Pule, Martin
Publicado 2016

IMMU-16. Next-generation CAR T-cells targeting IL13RA2 and secreting IL-15 achieve durable tumour clearance in pre-clinical model of diffuse midline glioma

por Hotblack, Alastair, Wawrzyniecka, Patrycja, Cheng, Gordon Weng-Kit, Nannini, Francesco, Pule, Martin, Straathof, Karin
Publicado 2022

Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging

por Badar, Adam, Kiru, Louise, Kalber, Tammy L, Jathoul, Amit, Straathof, Karin, Årstad, Erik, Lythgoe, Mark F, Pule, Martin
Publicado 2015

Establishment and phenotyping of neurosphere cultures from primary neuroblastoma samples

por Barton, Jack, Pacey, Katherine, Jain, Neha, Kasia, Tessa, Edwards, Darren, Thevanesan, Christine, Straathof, Karin, Barone, Giuseppe, Anderson, John
Publicado 2019

Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks

por Jones, Chris, Straathof, Karin, Fouladi, Maryam, Hargrave, Darren, Prados, Michael, Resnick, Adam, Doz, Francois, Jones, David T.W., Mueller, Sabine
Publicado 2023

Precise identification of cancer cells from allelic imbalances in single cell transcriptomes

por Trinh, Mi K., Pacyna, Clarissa N., Kildisiute, Gerda, Thevanesan, Christine, Piapi, Alice, Ambridge, Kirsty, Anderson, Nathaniel D., Khabirova, Eleonora, Prigmore, Elena, Straathof, Karin, Behjati, Sam, Young, Matthew D.
Publicado 2022

Cytotoxic T Lymphocyte Therapy for Epstein-Barr Virus(+) Hodgkin's Disease

por Bollard, Catherine M., Aguilar, Laura, Straathof, Karin C., Gahn, Benedikt, Huls, M. Helen, Rousseau, Alexandra, Sixbey, John, Gresik, M. Victoria, Carrum, George, Hudson, Melissa, Dilloo, Dagmar, Gee, Adrian, Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E.
Publicado 2004

IMMU-16. INTRA-TUMOURAL IL-12 DELIVERY ENABLES CAR T-CELL IMMUNOTHERAPY FOR HIGH-GRADE GLIOMA

por Agliardi, Giulia, Liuzzi, Anna Rita, Hotblack, Alastair, De Feo, Donatella, Núñez, Nicolás, Friebel, Ekaterina, Nannini, Francesco, Roberts, Thomas, Ramasawmy, Rajiv, Stowe, Cassandra, Williams, Iwan, Siow, Bernard, Lythgoe, Mark, Kalber, Tammy, Quezada, Sergio, Pule, Martin, Tugues, Sonia, Becher, Burkhard, Straathof, Karin
Publicado 2020

IMMU-05. TUMOR INFLAMMATION-ASSOCIATED NEUROTOXICITY (TIAN): A TOXICITY SYNDROME IN PATIENTS TREATED WITH IMMUNOTHERAPY FOR CENTRAL NERVOUS SYSTEM TUMORS

por Mahdi, Jasia, Dietrich, Jorg, Straathof, Karin, Roddie, Claire, Scott, Brian, Davidson, Tom Belle, Prolo, Laura, Batchelor, Tracy, Campen, Cynthia, Davis, Kara, Gust, Juliane, Lim, Michael, Majzner, Robbie, Park, Julie, Partap, Sonia, Ramakrishna, Sneha, Richards, Rebecca, Schultz, Liora, Vitanza, Nicholas, Wang, Leo, Mackall, Crystal, Monje, Michelle
Publicado 2023

Single-cell transcriptomics reveals a distinct developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia

por Khabirova, Eleonora, Jardine, Laura, Coorens, Tim H. H., Webb, Simone, Treger, Taryn D., Engelbert, Justin, Porter, Tarryn, Prigmore, Elena, Collord, Grace, Piapi, Alice, Teichmann, Sarah A., Inglott, Sarah, Williams, Owen, Heidenreich, Olaf, Young, Matthew D., Straathof, Karin, Bomken, Simon, Bartram, Jack, Haniffa, Muzlifah, Behjati, Sam
Publicado 2022

Pediatric pan-central nervous system tumor analysis of immune-cell infiltration identifies correlates of antitumor immunity

por Grabovska, Yura, Mackay, Alan, O’Hare, Patricia, Crosier, Stephen, Finetti, Martina, Schwalbe, Edward C., Pickles, Jessica C., Fairchild, Amy R., Avery, Aimee, Cockle, Julia, Hill, Rebecca, Lindsey, Janet, Hicks, Debbie, Kristiansen, Mark, Chalker, Jane, Anderson, John, Hargrave, Darren, Jacques, Thomas S., Straathof, Karin, Bailey, Simon, Jones, Chris, Clifford, Steven C., Williamson, Daniel
Publicado 2020

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

por Agliardi, Giulia, Liuzzi, Anna Rita, Hotblack, Alastair, De Feo, Donatella, Núñez, Nicolás, Stowe, Cassandra L., Friebel, Ekaterina, Nannini, Francesco, Rindlisbacher, Lukas, Roberts, Thomas A., Ramasawmy, Rajiv, Williams, Iwan P., Siow, Bernard M., Lythgoe, Mark F., Kalber, Tammy L., Quezada, Sergio A., Pule, Martin A., Tugues, Sonia, Straathof, Karin, Becher, Burkhard
Publicado 2021

Somatic mutations and single-cell transcriptomes reveal the root of malignant rhabdoid tumours

por Custers, Lars, Khabirova, Eleonora, Coorens, Tim H. H., Oliver, Thomas R. W., Calandrini, Camilla, Young, Matthew D., Vieira Braga, Felipe A., Ellis, Peter, Mamanova, Lira, Segers, Heidi, Maat, Arie, Kool, Marcel, Hoving, Eelco W., van den Heuvel-Eibrink, Marry M., Nicholson, James, Straathof, Karin, Hook, Liz, de Krijger, Ronald R., Trayers, Claire, Allinson, Kieren, Behjati, Sam, Drost, Jarno
Publicado 2021

Highlights of Children with Cancer UK’s Workshop on Drug Delivery in Paediatric Brain Tumours

por Nailor, Audrey, Walker, David A, Jacques, Thomas S, Warren, Kathy E, Brem, Henry, Kearns, Pamela R, Greenwood, John, Penny, Jeffrey I, Pilkington, Geoffrey J, Carcaboso, Angel M, Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G, Pearl, Monica S, Clifford, Steven C, Morrissy, Sorana, Ivanov, Delyan P, Beccaria, Kévin, Gilbertson, Richard J, Straathof, Karin, Green, Jordan J, Smith, Stuart, Rahman, Ruman, Kilday, John-Paul
Publicado 2016

Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

por Kildisiute, Gerda, Kholosy, Waleed M., Young, Matthew D., Roberts, Kenny, Elmentaite, Rasa, van Hooff, Sander R., Pacyna, Clarissa N., Khabirova, Eleonora, Piapi, Alice, Thevanesan, Christine, Bugallo-Blanco, Eva, Burke, Christina, Mamanova, Lira, Keller, Kaylee M., Langenberg-Ververgaert, Karin P.S., Lijnzaad, Philip, Margaritis, Thanasis, Holstege, Frank C.P., Tas, Michelle L., Wijnen, Marc H.W.A., van Noesel, Max M., del Valle, Ignacio, Barone, Giuseppe, van der Linden, Reinier, Duncan, Catriona, Anderson, John, Achermann, John C., Haniffa, Muzlifah, Teichmann, Sarah A., Rampling, Dyanne, Sebire, Neil J., He, Xiaoling, de Krijger, Ronald R., Barker, Roger A., Meyer, Kerstin B., Bayraktar, Omer, Straathof, Karin, Molenaar, Jan J., Behjati, Sam
Publicado 2021

Single cell derived mRNA signals across human kidney tumors

por Young, Matthew D., Mitchell, Thomas J., Custers, Lars, Margaritis, Thanasis, Morales-Rodriguez, Francisco, Kwakwa, Kwasi, Khabirova, Eleonora, Kildisiute, Gerda, Oliver, Thomas R. W., de Krijger, Ronald R., van den Heuvel-Eibrink, Marry M., Comitani, Federico, Piapi, Alice, Bugallo-Blanco, Eva, Thevanesan, Christine, Burke, Christina, Prigmore, Elena, Ambridge, Kirsty, Roberts, Kenny, Braga, Felipe A. Vieira, Coorens, Tim H. H., Del Valle, Ignacio, Wilbrey-Clark, Anna, Mamanova, Lira, Stewart, Grant D., Gnanapragasam, Vincent J., Rampling, Dyanne, Sebire, Neil, Coleman, Nicholas, Hook, Liz, Warren, Anne, Haniffa, Muzlifah, Kool, Marcel, Pfister, Stefan M., Achermann, John C., He, Xiaoling, Barker, Roger A., Shlien, Adam, Bayraktar, Omer A., Teichmann, Sarah A., Holstege, Frank C., Meyer, Kerstin B., Drost, Jarno, Straathof, Karin, Behjati, Sam
Publicado 2021